Effects of a fish oil emulsion on plasma free fatty acids, cytokines, and clinical outcomes in septic patients: a randomized, controlled, clinical trial

Barbosa, Vera M; Lafuente, E; Calhau, Conceição; Miles, Elizabeth; Calder, Philip C.

doi:10.1017/s0029665110000935

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“…51 Barbosa et al demonstrated that fish oil rich in EPA and DHA significantly lowers IL-6 and IL-10 concentration in patients with systemic inflammatory response syndrome or sepsis. 52 Meanwhile, we determined that all of the lipid fractions extracted from three kinds of BP exhibited antiinflammatory activity. In addition, BP-Cs containing more abundant phospholipids and unsaturated fatty acids possessed better anti-inflammatory activity than the other two.…”

Section: Discussionmentioning

confidence: 99%

UPLC-Q-Exactive Orbitrap/MS-Based Lipidomics Approach To Characterize Lipid Extracts from Bee Pollen and Their in Vitro Anti-Inflammatory Properties

Liang

Zhao

et al. 2017

J. Agric. Food Chem.

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Bee pollen (BP) is collected by honeybees from flower pollen mixed with nectar and its secretions with extensive nutritional and therapeutic properties. Lipids are known to be critical contributors for the therapeutic effects of BP and vary depending on different plant sources; however, lipid profiles of BP are not available. Here, an UPLC-Q-Exactive Orbitrap/MS method was established for comprehensive lipidomics analysis of BP derived from three major nectar plants (Brassica campestris L., Camellia sinensis L., and Nelumbo nucifera Gaertn.). A total of nine lipid classes, including phosphatidylcholine (41 species), phosphatidylethanolamine (43 species), phosphatidylglycerol (9 species), phosphatidylserine (10 species), lysophosphatidylcholine (12 species), ceramide (8 species), diglyceride (27 species), triglyceride (137 species), and fatty acids (47 species), were first identified and quantified in the three BPs. In vitro anti-inflammatory activity was also discovered in the lipid extracts of three BPs, which has potential relevance to the abundance of phospholipids and unsaturated fatty acids in BP. Our comprehensive lipidomics profiling and in vitro anti-inflammatory properties of BP provide evidence for its future application.

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Section: Discussionmentioning

confidence: 99%