Effects of a Fat-Free Diet on Growing Male Rats with Special Reference to the Endocrine System

Panos, Theodore C.; Finerty, John C.

doi:10.1093/jn/54.3.315

Cited by 54 publications

(6 citation statements)

References 13 publications

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“…However, degeneration did not occur in the Leydig cells which appeared more prominent. The histological changes occurring in the testes of the EFA-deficient animals were similar to those reported earlier (Evans et al 1934;Panos & Finerty, 1954).…”

Section: Discussionsupporting

confidence: 89%

Effect of Dietary Linoleic and Linolenic Acids on Testicular Development in the Rat

et al. 1983

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SUMMARYIn two experiments a total of twelve male rats were reared from weaning for up to 63 weeks on an essential fatty acid (EFA)-deficient diet alone (2 x two animals) or supplemented with the methyl esters of linoleic acid (18: 2w6) (2 x two animals) or linolenic acid (18: 3w3) (2 x two animals). Testicular development was normal in rats given 18:2w6, but in rats fed the EFAdeficient diet alone, and in those supplemented with 18:3w3 the testes were reduced in size. Histologically, a degeneration of the seminiferous tubules was noted, with progressive loss of the germinal cells, and with an absence of spermatozoa in the lumina of the seminiferous tubules and epididymides. Leydig cells appeared unaffected, and were prominent. The six rats in Experiment 1 were capable of mating with females reared on commercial diets, but only the two 18: 20)6 supplemented animals were fertile. There was a marked reduction in the percentage of arachidonic acid (20:4wj6) and docosapentaenoic acid (22: 516) in the total fatty acids of the atrophic testes. There was no compensatory increase in long-chain derivatives of 18: 3w3 in the 18: 3w3 fed rats and it is concluded that linolenic acid cannot replace linoleic acid in the development of the rat testis.

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Section: Discussionsupporting

confidence: 89%

Effect of Dietary Linoleic and Linolenic Acids on Testicular Development in the Rat

et al. 1983

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“…In our experiments such pronounced infertility as that seen by Burr & Burr (1930), Evans et al (1934c), Panos & Finerty (1954), Panos et al (1959) and Panos (1963) (Table 3). The weight of the seminal vesicles, however, was significantly greater in the rats receiving PGE2 than in those in the remaining three groups.…”

Section: Male Fertilitysupporting

confidence: 71%

Prostaglandin E2 Prevents Impairment of Fertility in Rats Fed a Diet Deficient in Essential Fatty Acids

Hafiez¹

1974

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Summary. Male and female rats were fed a diet deficient in essential fatty acids for 5 months, starting at weaning. Some of these animals received no other treatment, while others were given prostaglandin E2, methyl arachidonate or a regular diet (Purina Lab Chow). At 3 and 6 months of age, the experimental rats were mated with untreated animals. At 3 months, only seven of eleven males fed the fat-free diet alone were fertile, while all males in the other three groups were fertile. At 6 months, five of eleven males fed the fat-free diet alone, ten of eleven males fed the fat-free diet plus methyl arachidonate, and all rats treated with prostaglandin or fed the regular diet were fertile.At 3 months, the females in the group fed the fat-free diet alone had irregular oestrous cycles, a prolonged gestation period and a smaller litter size than those in the other groups. Treatment with PGE2 had a deleterious effect on lactation, the lactation efficiency index being 0\m=.\4 in this group compared to 0\m=.\8to 0\m=.\9in the remaining three groups.At 6 months, most females were fertile and normal numbers of corpora lutea and implantation sites were observed in all groups.Prostaglandin E2 was apparently as effective as methyl arachidonate in preventing the impairment of fertility in rats fed the fat-free diet. Arachidonic acid is the major precursor for biosynthesis of prostaglandins E2 and F2\ g=a\ .

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“…Aaes-Jorgensen & Holman (1958) reported decreases in testis content of unsaturated fatty acids due to dietary deficiencies in essential fatty acids. The sterility induced by fatty acid deficiency was apparently due to degeneration of the seminiferous tubules since no changes were seen in the interstitial cells (Panos & Finerty, 1954). Supplementary linoleic acid contributes to the return of normal spermatogenesis (Aaes-Jorgensen, Funch, Engel & Dam, 1956), and cholesterol (1%) added to an essential fatty acid deficient diet hastened the appearance of degeneration to 2 weeks from the 3-month periods previously observed (Pfiefer & Holman, 1955).…”

Section: Introductionmentioning

confidence: 87%

Biochemical Changes in Rat Testis During Postnatal Maturation

Ewing¹,

Means²,

Beames³

et al. 1966

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Effects of a Fat-Free Diet on Growing Male Rats with Special Reference to the Endocrine System

Cited by 54 publications

References 13 publications

Effect of Dietary Linoleic and Linolenic Acids on Testicular Development in the Rat

Effect of Dietary Linoleic and Linolenic Acids on Testicular Development in the Rat

Prostaglandin E2 Prevents Impairment of Fertility in Rats Fed a Diet Deficient in Essential Fatty Acids

Biochemical Changes in Rat Testis During Postnatal Maturation

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