Effects of a derivative thiazoline/thiazolidine azine ligand and its cadmium complexes on phagocytic activity by human neutrophils

Viñuelas-Zahı́nos, E.; Luna‐Giles, F.; Torres-García, P.; Rodríguez, Ana B.; Bernalte‐García, A.

doi:10.1016/j.ica.2010.11.037

Cited by 15 publications

(6 citation statements)

References 49 publications

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“…They are of particular importance in the development of light-based technology for communication and computing [14]. These compounds have pharmacological and biological properties and close relationships with their structures, which act as anti-inflammatory, analgesic, antibacterial, antifungal, antitumor, anti-HIV and antimicrobial agents [15][16][17][18][19]. Azines are also important for drug design, organocatalysis and synthesis of heterocyclic compounds [20][21] by undergoing different types of cyclo-addition reactions [21][22].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, molecular structure analyses and DFT studies on new asymmetrical azines based Schiff bases

Yahyaoui

Bouchama²,

Anak³

et al. 2019

Journal of Molecular Structure

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In this paper, we report the synthesis of new unsymmetrical azines Schiff bases. These compounds were prepared by condensation of hydrazine with different aldehydes and ketones to give (E) -2-hydroxynaphthalene-1-carbaldehyde [(1E) -2-thienylmethylene] hydrazone compound (I) and (Z) -2 -[(E) -1-(2-hydroxyphenyl) ethylidenehydrazin-1-ylidene] -1,2diphenylethanone compound (II). The method adopted consists in reacting the two different carbonyl compounds simultaneously in one step in a stepwise manner reported which is practical and cost-effective. The reaction with a minor modification in operating conditions proceeded efficiently and with excellent performance. The structure of each of the two compounds (I) and (II) was determined by the X-ray diffraction technique performed on single crystals. The asymmetric unity of the two molecules consists of one asymmetry-independent molecule. In addition, hydrogen bonds C-H ... π are observed in the compound (II). We then present a detailed DFT study based on B3LYP / 6-31G (d, p) geometric structures of compounds (I); (II) and another compound (III) also another asymmetric azine (Z) -2 -[(E) -2-benzylidenehydrazine-1-ylidene] -1,2diphenylethanone whose crystal structure is reported. The fundamental vibration wave numbers are calculated and a good agreement between the observed and calculated wave numbers is obtained. The study was extended to the HOMO-LUMO analysis to calculate the energy gap. The calculated HOMO and LUMO energy reveals that the charge is transferred into the molecule.

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Section: Introductionmentioning

confidence: 99%

Synthesis, molecular structure analyses and DFT studies on new asymmetrical azines based Schiff bases

Yahyaoui

Bouchama²,

Anak³

et al. 2019

Journal of Molecular Structure

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“…The product obtained was confirmed and characterized through elemental analysis and spectroscopic techniques, while the crystal structure was also determined. In addition, Torres-García and coworkers investigated the phagocytosis process of human neutrophils that was increased when treated with the Zn (II) complexes [21] and similar observations were reported for cadmium complexes with other ligands [22].…”

Section: Green Syntheses Of Thiazines and Their Derivativesmentioning

confidence: 77%

Bioactive Thiazine and Benzothiazine Derivatives: Green Synthesis Methods and Their Medicinal Importance

Badshah

Akhtar

2016

Molecules

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Abstract:Thiazines are a group of heterocyclic organic compounds that are still largely unexplored for their pharmacological activities. There are different available methods for the synthesis of thiazine derivatives in the literature. In this review, we discuss available methods of thiazine preparation through green synthesis methods. Beside their synthesis, many thiazine derivatives are biologically active and play an important role in the treatment of various diseases and show promising results of varying degrees, where they act as antibacterial, antifungal, antitumor, antimalarial, antineoplastic, antiviral, anti-inflammatory, analgesic and anticancer agents and thus they represent an interesting class of heterocyclic medicinal compounds worthy of further exploration.

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“…Infrared spectral studies clearly reveal that binding modes of the ligand is through deprotonated phenolic oxygen and heterocyclic nitrogen atoms and there is no role of anions from the M 2+ salts in the inner coordination spheres of the complexes. Therefore the ligand behaves as a neutral bidentate ligand coordinated, to Hg (II) ions, through the nitrogen atoms of the ring, and oxygen atoms of the phenolic groups to give a four membered chelate ring complexes (Viñuelas-Zahínos et al, 2011). However, the ligand acting as monodentate coordinating through phenolic oxygen in case of Zn(II) and Cd(II) complexes.…”

Section: Ftir Spectral Analysis Resultsmentioning

confidence: 99%

Spectrophotometric study on the stability constants and thermodynamic parameters of Zn2+, Cd2+ and Hg2+ complexes with Imino Thiazolidinone

Gemechu¹,

Kebede²,

Demissie³

et al. 2015

Afr. J. Pure Appl. Chem.

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The heterocyclic ligand (L), 3-(2-hydroxy phenyl)-2-iminothiazolidin-4-one, was synthesized by the cyclocondensation of o-hydoxy phenyl chloroacetamide with potassium thiocyanate. The stoichiometries of the title complexes were first determined by spectrophotometric mole ratio method which gave rise to the M:L ratio of 1:4 in case of Zn(II) and Cd(II) and 1:2 in case of Hg(II) ions respectively. Using these predetermined M:L ratios, complexes of the formulas [Zn-L 4 ], [Cd-L 4 ] and [Hg-L 2 ] were prepared accordingly using precursor of the corresponding metal salts with the title ligand in ethanol medium. The synthesized compounds were characterized by elemental analysis, FTIR, 1 H and 13 CNMR, UV-Vis and conductometric measurement. Stability constants (K s ) of these complexes were investigated by spectrophotometric mole ratio method. The FTIR, 1 H NMR and 13C NMR data revealed that the studied ligand function as monodentate ligand interacting through phenolic oxygen as donor with Zn(II) and Cd(II) and as bidentate ligand interacting through phenolic oxygen and nitrogen atom with Hg(II). The synthesized complexes show conductivity values in the range of 122-133 µSmol -1 cm 2 in DMSO at 298 K which confirms the electrolytic nature of the complexes. The stability constants decreased with increased temperature, confirming that these metal complexes are not stable at higher temperature. Sufficiently large negative values of ΔG of complex confirm the spontaneous formation of the title complexes. Furthermore, it was noted that the spontaneity of the reaction increased with temperature. The stability constant of these complexes follow the sequence Zn(II)>Cd(II)>Hg(II). Therefore, the overall result is complying very well with the Irving-William series of stability constants of metal complexes.

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Effects of a derivative thiazoline/thiazolidine azine ligand and its cadmium complexes on phagocytic activity by human neutrophils

Cited by 15 publications

References 49 publications

Synthesis, molecular structure analyses and DFT studies on new asymmetrical azines based Schiff bases

Synthesis, molecular structure analyses and DFT studies on new asymmetrical azines based Schiff bases

Bioactive Thiazine and Benzothiazine Derivatives: Green Synthesis Methods and Their Medicinal Importance

Spectrophotometric study on the stability constants and thermodynamic parameters of Zn2+, Cd2+ and Hg2+ complexes with Imino Thiazolidinone

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