Effects of a Contusion Injury on Spinal Cord Blood Flow in the Sheep

Jd, Yeo; Hales,; Stabback, S; Bradley, Sally; Aa, Fawcett; Kearns, R.

doi:10.1097/00007632-198410000-00004

Cited by 9 publications

(3 citation statements)

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“…We create a contusive injury on the spinal cord in our ovine model using a modified version of a standard weight-drop technique 28,29 which was first employed in sheep by Yeo and colleagues [30][31][32][33][34] and used recently in swine. 25 The configuration of our custom apparatus, designed to achieve a repeatable level of incomplete SCI, is shown in Figure 1.…”

Section: Sci Methodologymentioning

confidence: 99%

An ovine model of spinal cord injury

Wilson

Abode-Iyamah

et al. 2016

The Journal of Spinal Cord Medicine

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Section: Sci Methodologymentioning

confidence: 99%

An ovine model of spinal cord injury

Wilson

Abode-Iyamah

et al. 2016

The Journal of Spinal Cord Medicine

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“…The sheep spine consists of 7 cervical, 12-14 thoracic, and 6-7 lumbar vertebrae, with dimensions of the vertebral bodies, pedicles, spinous and transverse processes, and the spinal canal most similar to humans in the thoracic and lumbar regions ( 10 , 11 ). Consequently, sheep have been used to model spinal cord injury, particularly contusive injuries, since the 1970's ( 113 – 115 ). These early studies were the first to characterize cell death, gliosis, axonal swelling, and vascular damage and noted the presence of irreversible damage as early as four hours after injury ( 113 , 115 ).…”

Section: Experimentally Induced Sheep Disease Modelsmentioning

confidence: 99%

“…Consequently, sheep have been used to model spinal cord injury, particularly contusive injuries, since the 1970's ( 113 – 115 ). These early studies were the first to characterize cell death, gliosis, axonal swelling, and vascular damage and noted the presence of irreversible damage as early as four hours after injury ( 113 , 115 ).…”

Section: Experimentally Induced Sheep Disease Modelsmentioning

confidence: 99%

The Translational Benefits of Sheep as Large Animal Models of Human Neurological Disorders

Murray

Mitchell

2022

Front. Vet. Sci.

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The past two decades have seen a considerable rise in the use of sheep to model human neurological disorders. While each animal model has its merits, sheep have many advantages over small animal models when it comes to studies on the brain. In particular, sheep have brains more comparable in size and structure to the human brain. They also have much longer life spans and are docile animals, making them useful for a wide range of in vivo studies. Sheep are amenable to regular blood and cerebrospinal fluid sampling which aids in biomarker discovery and monitoring of treatment efficacy. Several neurological diseases have been found to occur naturally in sheep, however sheep can also be genetically engineered or experimentally manipulated to recapitulate disease or injury. Many of these types of sheep models are currently being used for pre-clinical therapeutic trials, particularly gene therapy, with studies from several models culminating in potential treatments moving into clinical trials. This review will provide an overview of the benefits of using sheep to model neurological conditions, and highlight naturally occurring and experimentally induced sheep models that have demonstrated translational validity.

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