Effects of a constant light environment on hippocampal neurogenesis and memory in mice

Fujioka, Aya; Fujioka, Takashi; Tsuruta, Ryosuke; Izumi, Takeki; Kasaoka, Shunji; Maekawa, Taira

doi:10.1016/j.neulet.2010.11.001

Cited by 74 publications

(54 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BrdU-labeled proliferating cells show a dark/light cycle-dependent pattern (114). M-phase cells increase during the night (115), and constant light exposure decreases neurogenesis in the dentate gyrus (116). Clock genes (Per1, Per2, Cry1, Cry2, Bmal1, and Clock), which are expressed in the dentate gyrus of the hippocampus (117) in neural progenitor cells, can regulate these proliferation and differentiation transcription factors (118).…”

Section: Central and Peripheral Nscs Agingmentioning

confidence: 99%

Effects of Melatonin on Nervous System Aging: Neurogenesis and Neurodegeneration

et al. 2013

View full text Add to dashboard Cite

Abstract. Neural aging as a progressive loss of function involves central and peripheral postmitotic neurons and neural stem cells (NSCs). It promotes neurodegeneration, impairs neurogenesis, and can be considered a cause of cognitive impairment and sensory and motor deficits in the elderly. Age-related morphological atrophic changes and cellular alterations are addressed by neural aging mechanisms. Neurogenesis declines during aging through several mechanisms such as an increase in quiescence state, changes in lineage fate, telomerase dysfunction, the failure of the DNA repair system, increased apoptosis, and the impairment of self-renewal. The selfrenewal transcriptional factor Sox2 has been correlated with retrotransposon L1 and certain cellcycle-and epigenetic-related factors, which are sometimes considered age-related factors in NSC aging. As neurogenesis decreases, non-mitotic neurons undergo neurodegeneration by oxidative stress, sirtuin, insulin signaling and mTOR alteration, mitochondrial dysfunction, and protein misfolding and aggregation. As neurodegeneration and impaired neurogenesis promote the nervous system aging process, the identification of neuronal anti-aging is required to raise life expectancy. The role of melatonin in increasing neurogenesis and protecting against neurodegeneration has been investigated. Here, we review nervous system aging that is correlated with mechanisms of neurodegeneration and the impairment of neurogenesis and evaluate the effects of melatonin on these processes.

show abstract

Section: Central and Peripheral Nscs Agingmentioning

confidence: 99%

Effects of Melatonin on Nervous System Aging: Neurogenesis and Neurodegeneration

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Once mice located the platform, they were permitted to remain on it for 10 sec. If mice did not locate the platform within 90 sec, they were placed on the platform for 10 sec and then removed from the pool, as previously described (14,15).…”

Section: Volume Measurement Of the Granular Cell Layer Of The Dgmentioning

confidence: 99%

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Akazawa

Kitamura

Fujihara

et al. 2012

International Journal of Molecular Medicine

View full text Add to dashboard Cite

Abstract. In this study, we examined the effect of forced mastication on neurogenesis in the hippocampal dentate gyrus (DG) of adult mice. Six-week-old mice were subjected to either a hard or normal diet for 13 weeks. They received a daily injection of bromodeoxyuridine (BrdU) for 12 consecutive days beginning at 14 weeks of age. The number of BrdU-positive cells in the DG was counted 1 day after and 5 weeks after the final BrdU injection. The number of BrdU-positive cells 1 day after injection did not differ between the 2 diet groups. However, the number of BrdU-positive cells in the group fed the hard diet was significantly increased 5 weeks after BrdU injection compared to the group fed the normal diet. The results of the Morris water maze test showed that mice fed a hard diet required significantly less time to reach the platform than the control mice when tested at 10 days. Moreover, mice in the group fed the hard diet spent significantly more time in the former platform area than the group fed the normal diet, indicating that hard diet feeding improved spatial memory compared to normal diet feeding. Real-time PCR analysis showed that the expression of glutamate receptor 1 mRNA was significantly increased in the group fed the hard diet compared with the group fed the normal diet. These results suggest that mastication increases the survival of adult neural stem cells in the hippocampal DG.

show abstract

“…The number of BrdU-labeled cells (proliferating cells) as well as BrdU and Class-III -tubulin double-labeled cells (newborn neurons) significantly decreased in the granule cell layer of the L/L group compared with that of the L/D group. Also Fujioka found that the exposure to an L/L treatment for 3 weeks impaired spatial learning task performance; These findings demonstrate that constant light conditions impaired hippocampal neurogenesis and cognitive performance (Fujioka et al, 2011).…”

Section: Memory and Circadian Rhythmmentioning

confidence: 79%

Chronobiological Aspects of Mood Disorders

Levandovski¹,

Harb²,

Bernardi³

et al. 2012

Clinical, Research and Treatment Approaches to Affective Disorders

View full text Add to dashboard Cite

Effects of a constant light environment on hippocampal neurogenesis and memory in mice

Cited by 74 publications

References 30 publications

Effects of Melatonin on Nervous System Aging: Neurogenesis and Neurodegeneration

Effects of Melatonin on Nervous System Aging: Neurogenesis and Neurodegeneration

Forced mastication increases survival of adult neural stem cells in the hippocampal dentate gyrus

Chronobiological Aspects of Mood Disorders

Contact Info

Product

Resources

About