Effects of a combined physical and psychosocial intervention program for childhood cancer patients on quality of life and psychosocial functioning: results of the QLIM randomized clinical trial

Dijk-Lokkart, Elisabeth M. van; Braam, Katja I.; Broeder, Eline van Dulmen‐den; Kaspers, Gertjan J. L.; Takken, Tim; Grootenhuis, Martha A.; Streng, Isabelle; Bierings, Marc; Merks, Johannes H. M.; Heuvel‐Eibrink, Marry M. van den; Veening, Margreet A.; Huisman, J.

doi:10.1002/pon.4016

Cited by 45 publications

(87 citation statements)

References 32 publications

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“…Finally, this was a post hoc analysis of the QLIM study in which no distinction was made between the intervention and the control group. Even though no significant effect of the combined physical exercise and psychosocial training program on physical fitness was found, there may have been some beneficial effects of participating in the QLIM study on an individual level that may have influenced our results.…”

Section: Discussionmentioning

confidence: 88%

“…There were no significant beneficial effects of the QLIM intervention on physical fitness, physical and psychosocial function at 4 and 12 months, except for a larger improvement in lower body muscle strength at 12 months in the intervention group. [26][27][28] Therefore, patients were evaluated together for the purpose of the present study, irrespective of the QLIM study group they were originally assigned to.…”

Section: Discussionmentioning

confidence: 99%

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Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Dijk-Lokkart

Steur

Braam

et al. 2019

Pediatric Blood & Cancer

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Purpose Cancer‐related fatigue is one of the most distressing side effects of childhood cancer treatment. Physical activity can decrease fatigue and has positive effects on other health outcomes. Most research on physical activity pertains to adults, and the few studies that focus on children have limited follow‐up time. This study evaluates cancer‐related fatigue in children and its association with physical activity over a one‐year time period. Methods Sixty‐eight children with cancer (7–18 years) were recruited during or within the first year after treatment. Physical activity (Actical activity monitor) and cancer‐related fatigue (Pediatric Quality‐of‐Life Questionnaire Multidimensional Fatigue Scale (PedsQL‐MFS), self‐ and parent‐ reports) were assessed at baseline, 4 months, and 12 months. PedsQL‐MFS scores were compared with Dutch norms. Longitudinal association of cancer‐related fatigue with physical activity was evaluated (No. NTR 1531). Results Generally, PedsQL‐MFS scores were worse than norms at baseline and 4 months, and recovered by 12 months except for the parent‐proxy scores in adolescents. Younger children (≤12 years) self‐reported comparable or better scores than norms. Physical activity generally improved over time, but patients mostly remained sedentary. During follow‐up, increased physical activity was associated with less cancer‐related fatigue. Conclusion Cancer‐related fatigue in children improves over time, and increased physical activity is associated with less cancer‐related fatigue. Given the sedentary lifestyle of this population, the positive effect of physical activity on cancer‐related fatigue, and the many other health benefits of an active lifestyle, it is important to stimulate physical activity in childhood cancer patients and survivors.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Dijk-Lokkart

Steur

Braam

et al. 2019

Pediatric Blood & Cancer

Self Cite

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“…The randomization process was adequately specified in five studies and in three studies it remained unclear . Four studies included patients during the maintenance phase: two studies indicated the timing as “after diagnosis” and in two studies the treatment phase was not specified .…”

Section: Selected Studies Analysismentioning

confidence: 99%

Exercise program for children and adolescents with leukemia and lymphoma during treatment: A comprehensive review

Zucchetti

Rossi

Viña

et al. 2018

Pediatric Blood & Cancer

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An exercise program (EP) during cancer treatment seems to be a valid strategy against physiological and quality-of-life impairments, but scientific evidence of benefits among pediatric patients is still limited. This review summarizes the literature focused on randomized controlled trials of EP offered to patients during leukemia and lymphoma treatment. Studies published up to June 2017 were selected from multiple databases and assessed by three independent reviewers for methodological validity. The review identified eight studies, but several types of bias have to be avoided to provide evidence-based recommendations accessible to patients, families, and professionals.

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“…Given the documented impact of emotional health on quality of life, combining physical exercise interventions with psychosocial training during this time period would seem reasonable if the goal of intervention was to also improve quality of life. However a small randomized trial evaluating combined physical exercise and psychosocial training indicates that intervention does not result in appreciable differences in either fitness or health related quality of life if administered during or in the first year after cancer therapy [39]. It may be that interventions delivered this early that also require significant exertion and cognitive attention are too difficult for children to participate in while they are acutely ill.…”

Section: Potential Interventions For Fitness and Quality Of Life In Cmentioning

confidence: 99%

Frailty and quality of life in adult survivors of childhood cancer

Ness

Howell

Bjornard

2017

Expert Review of Quality of Life in Cancer Care

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Introduction Adult survivors of childhood cancer are at risk for frailty, a state of diminished physiologic reserve, typically seen in older adults, associated with morbidity and mortality. They are also at risk for poor quality of life. This review explores potential associations between frailty and quality of life and proposes potential interventions that may prevent or remediate frail health. Areas covered and literature search A literature search using MEDLINE and EMBASE was undertaken using key words: childhood cancer survivors and each of the following: frailty, physical performance, emotional health, and quality of life. 796 abstracts were reviewed for relevance. Reference lists for retrieved articles were consulted for pertinent manuscripts (N=40). Recent literature (from January 2013 to November 2016) was obtained using the key words: aging and frailty and quality of life. The final reference list includes 44 documents. Expert opinion Childhood cancer survivors are at risk for frailty and less than optimal quality of life. Poor emotional health may contribute to this association. Further research is needed to better explain these associations and to provide a foundation for the development of interventions designed to prevent and remediate frail health and suboptimal quality of life in this population.

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Effects of a combined physical and psychosocial intervention program for childhood cancer patients on quality of life and psychosocial functioning: results of the QLIM randomized clinical trial

Abstract: A combined physical and psychosocial training for children with cancer did not have effects on HrQoL or psychosocial functioning, with exception of modest positive effects on parent-reported pain and procedural anxiety Copyright © 2015 John Wiley & Sons, Ltd.

Cited by 45 publications

References 32 publications

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Longitudinal development of cancer‐related fatigue and physical activity in childhood cancer patients

Exercise program for children and adolescents with leukemia and lymphoma during treatment: A comprehensive review

Frailty and quality of life in adult survivors of childhood cancer

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