Effects of a chronic Helicobacter pylori infection on the gastric mucus gel in vivo

Atuma, Christer; Johansson, M.; Engstrand, Lars; Li, H.; Holm, Lena

doi:10.1016/s0016-5085(98)80247-3

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“…This increase in mucus thickness was solely a renewal of the loosely adherent mucus layer, because the thickness of the firmly adherent mucus layer was the same after a second mucus removal as that following the initial mucus removal by suction. In another study, using the same experimental setup, the gastric pathogen Helicobacter pylori has been shown to reduce the rate of renewal of the mucus layer removed by suction, as well as an acid-induced increase in its renewal rate (7).…”

Section: Discussionmentioning

confidence: 92%

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The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo

Atuma

Strugala

Allen

et al. 2001

American Journal of Physiology-Gastrointestinal and Liver Physi

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Divergent results from in vitro studies on the thickness and appearance of the gastrointestinal mucus layer have previously been reported. With an in vivo model, we studied mucus gel thickness over time from stomach to colon. The gastrointestinal tissues of Inactin-anesthetized rats were mounted luminal side up for intravital microscopy. Mucus thickness was measured with a micropipette before and after mucus removal by suction. The mucus layer was translucent and continuous; it was thickest in the colon (approximately 830 microm) and thinnest in the jejunum (approximately 123 microm). On mucus removal, a continuous, firmly adherent mucus layer remained attached to the epithelial surface in the corpus (approximately 80 microm), antrum (approximately 154 microm), and colon (approximately 116 microm). In the small intestine, this layer was very thin (approximately 20 microm) or absent. After mucus removal, there was a continuous increase in mucus thickness with the highest rate in the colon and the lowest rate in the stomach. In conclusion, the adherent gastrointestinal mucus gel in vivo is continuous and can be divided into two layers: a loosely adherent layer removable by suction and a layer firmly attached to the mucosa.

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Section: Discussionmentioning

confidence: 92%

“…Thus continuous secretion of mucus maintains its protective mucosal barrier properties. However, the mucus layer can be compromised in pathological states such as Helicobacter pylori infection, peptic ulcer disease, and ulcerative colitis, during which both mucus thickness and structure are major targets (7,31,34,35,42,47).…”

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confidence: 99%