Effects of a bupivacaine nerve block on the axonal transport of Tumor Necrosis Factor-alpha (TNF-α) in a rat model of carrageenan-induced inflammation

Deruddre, Stéphane; Combettes, Evelyne; Estèbe, Jean-Pierre; Duranteau, Jacques; Benhamou, Dan; Beloeil, Hélène; Mazoit, Jean‐Xavier

doi:10.1016/j.bbi.2010.01.013

Cited by 26 publications

(34 citation statements)

References 31 publications

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“…When treated with bupivacaine, the TNFα-receptor 1 levels maintained their basal concentration. 48 This concentration differed significantly from the control mice. 48 TNFα-receptor 2 levels were also found to have low concentrations at baseline.…”

Section: Inflammatory Responsementioning

confidence: 79%

“…48 This concentration differed significantly from the control mice. 48 TNFα-receptor 2 levels were also found to have low concentrations at baseline. Additionally, these levels did not increase when inflammation was induced with carrageenan.…”

Section: Inflammatory Responsementioning

confidence: 79%

“…The colchicine group had levels of TNFα transport that were statistically different from controls; however this difference only lasted during the first 24 hours. 48 By hour 30, the difference was gone. 48 In the three hours after carrageenan injection, there was a significant increase in TNFα-receptor 1 levels which plateaued at the 3 hour mark.…”

Section: Inflammatory Responsementioning

confidence: 99%

“…48 By hour 30, the difference was gone. 48 In the three hours after carrageenan injection, there was a significant increase in TNFα-receptor 1 levels which plateaued at the 3 hour mark. When treated with bupivacaine, the TNFα-receptor 1 levels maintained their basal concentration.…”

Section: Inflammatory Responsementioning

confidence: 99%

“…Using carrageenan injections to induce inflammation, the study revealed that, relative to mice without nerve blocks, those with nerve block had markedly decreased edema after injection. 48 To study the influence of PNBs on axonal transport, they used five study groups: one received a saline nerve block (control), the second received drug-free microspheres (control), the third received bupivacaine, the fourth received colchicine, and the fifth received an epinephrine block. During the 36-hour study period a significant decrease in the transport of TNFα occurred when comparing the controls to the bupivacaine nerve block.…”

Section: Inflammatory Responsementioning

confidence: 99%

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Physiologic Advantages of Peripheral Nerve Blockade Translate to Decreased Length of Stay and Improved Patient Satisfaction

Kerfeld¹,

Hambsch²,

McEntire³

et al. 2016

Anesthesiol Open J

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Review ABSTRACTPeripheral nerve blockade is an effective modality involved in controlling perioperative pain. When compared with patient controlled analgesia, neuraxial analgesia, and other anesthetic methods such as periarticular infiltration, peripheral nerve blocks yield superior pain control and reduce length of hospitalization. Not only do these techniques help with patient satisfaction and health care costs, they also have physiologic advantages. In murine models, peripheral nerve blockade reduces expression of different inflammatory markers such as IL-1, IL-6, TNFα and cortisol. Such advantages make this an attractive modality for pain control.

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Section: Inflammatory Responsementioning

confidence: 79%

Section: Inflammatory Responsementioning

confidence: 79%