Effects of a Brazilian cardioprotective diet and nuts on cardiometabolic parameters after myocardial infarction: study protocol for a randomized controlled clinical trial

Abstract

Background Nut consumption has been related to improvements on cardiometabolic parameters and reduction in the severity of atherosclerosis mainly in primary cardiovascular prevention. The objective of this trial is to evaluate the effects of the Brazilian Cardioprotective Diet (DIetaCArdioprotetoraBrasileira, DICA Br) based on consumption of inexpensive locally accessible foods supplemented or not with mixed nuts on cardiometabolic features in patients with previous myocardial infarction (MI). Methods DICA-NUTS study is a national, multicenter, randomized 16-week follow-up clinical trial. Patients over 40 years old with diagnosis of previous MI in the last 2 to 6 months will be recruited (n = 388). A standardized questionnaire will be applied to data collection and blood samples will be obtained. Patients will be allocated in two groups: Group 1: DICA Br supplemented with 30 g/day of mixed nuts (10 g of peanuts, 10 g of cashew, 10 g of Brazil nuts); and Group 2: only DICA Br. The primary outcome will consist of LDL cholesterol means (in mg/dL) after 16 weeks of intervention. Secondary outcomes will consist of other markers of lipid profile, glycemic profile, and anthropometric data. Discussion It is expected that DICA Br supplemented with mixed nuts have superior beneficial effects on cardiometabolic parameters in patients after a MI, when compared to DICA Br. Trial registration ClinicalTrials.gov Identifier NCT03728127. First register: November 1, 2018; Last update: June 16, 2021. World Health Organization Universal Trial Number (WHO-UTN): U1111-1259-8105.

Absolute and Relative Agreement between the Current and Modified Brazilian Cardioprotective Nutritional Program Dietary Index (BALANCE DI) and the American Heart Association Healthy Diet Score (AHA-DS) in Post Myocardial Infarction Patients

“…This is a cross-sectional analysis of baseline data from the DICA-NUTS Study, for which a detailed protocol was previously published [ 18 ]. Briefly, DICA-NUTS is a 16-week, parallel, multicenter, randomized clinical trial (ClinicalTrials.gov NCT03728127) carried out in four regions of Brazil (Northeast, Southeast, South, and Midwest), from January 2019 to December 2021 [ 18 ]. The study included patients over 40 years old with diagnosed MI, either ST-Elevation MI (STEMI) or non-STEMI in the last 2 to 6 months.…”

“…At baseline, participants completed questionnaires on sociodemographic, lifestyle, medical, and dietary intake. All data were collected by trained nutritionists [ 18 ]. Ethical approval for the analysis was provided by Research Ethics Committee of Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia (IC/FUC) under number 5.115.455 (CAAE 52734921.0.0000.5333).…”

“…At baseline, participants completed one 24-h food recall (24hR) and a semi-quantitative Food Frequency Questionnaire (FFQ) [ 18 ]. Both tools were administered on the same day during the participant’s first appointment.…”

“…The FFQ collected data on their consumption over the previous 365 days. A photo album with standardized household measures or grams was used in both the 24hR and FFQ [ 18 , 19 ]. For the analysis of the 24hR, a computerized system (Sistema Vivanda de Alimentação ® , São Paulo, Brazil) was used that prioritizes Brazilian nutrition composition tables [ 18 ].…”

Correction to: Effects of a Brazilian cardioprotective diet and nuts on cardiometabolic parameters after myocardial infarction: study protocol for a randomized controlled clinical trial

“…Following the publication of the original article [ 1 ], we were notified that Tables 3 and 4 were identical.…”