Effects of 99mTc-TRODAT-1 drug template on image quantitative analysis

Abstract

99mTc-TRODAT-1 is a type of drug that can bind to dopamine transporters in living organisms and is often used in SPCT imaging for observation of changes in the activity uptake of dopamine in the striatum. Therefore, it is currently widely used in studies on clinical diagnosis of Parkinson’s disease (PD) and movement-related disorders. In conventional 99mTc-TRODAT-1 SPECT image evaluation, visual inspection or manual selection of ROI for semiquantitative analysis is mainly used to observe and evaluate the degree of striatal defects. However, these methods are dependent on the subjective opinions of observers, which lead to human errors, have shortcomings such as long duration, increased effort, and have low reproducibility. To solve this problem, this study aimed to establish an automatic semiquantitative analytical method for 99mTc-TRODAT-1. This method combines three drug templates (one built-in SPECT template in SPM software and two self-generated MRI-based and HMPAO-based TRODAT-1 templates) for the semiquantitative analysis of the striatal phantom and clinical images. At the same time, the results of automatic analysis of the three templates were compared with results from a conventional manual analysis for examining the feasibility of automatic analysis and the effects of drug templates on automatic semiquantitative analysis results. After comparison, it was found that the MRI-based TRODAT-1 template generated from MRI images is the most suitable template for 99mTc-TRODAT-1 automatic semiquantitative analysis.

Cognitive impairment in schizophrenia is associated with prefrontal–striatal functional hypoconnectivity and striatal dopaminergic abnormalities

“…We calculated the specific uptake ratio to represent DAT availability in four regions of interest (bilateral CN and putamen), with the occipital lobe as the reference region. An automated semiquantitative software validated for 99mTc-TRODAT images was used for quantification (Wu et al, 2018a). The asymmetry index (AI) of DAT availability was defined as (right − left)/(right + left) (Hsiao et al, 2003; Laakso et al, 2000).…”

Imaging modalities in differential diagnosis of Parkinson’s disease: opportunities and challenges

“…99m Tc-TRODAT-1 TRODAT-1, a 99m Tc-labeled tropane derivative, is a cocaine analogous that can attach to the dopamine transporter (DAT) sites at presynaptic neuron membrane which is beneficial as a potential CNS dopamine transporter imaging agent and can be labeled with 99m Tc without difficulty in most nuclear medicine departments all over the world [106].…”