Effects of 95% ethanol extract of Aquilaria sinensis leaves on hyperglycemia in diabetic db/db mice

Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology

“…This ethnopharmacological evidence, together with the current trends in bioprospecting, have spurred the interest of the scientific community to investigate claims using modern tools. This is manifested in the surge of the number of scientific publications in recent years, particularly those describing the pharmacological actions of agarwood, including the antidiabetic Jiang and Tu, 2011;Pranakhon et al, 2015;Zulkiflie et al, 2013), anti-inflammatory (Chitre et al, 2007;Kumphune et al, 2011;Rahman et al, 2012;Sattayasai et al, 2012;Zhou et al, 2008), anti-cancer (Dahham et al, 2014;Dahham, 2015a;Gunasekera et al, 1981;Hashim et al, 2014a), anti-depressant (Okugawa et al, 1993;Takemoto et al, 2008), and anti-oxidant (Dahham et al, 2014;Han and Li, 2012;Huda et al, 2009;Kamonwannasit et al, 2013;Miniyar et al, 2008;Moosa, 2010;Nik Wil et al, 2014;Owen and Jones, 2002;Ray et al, 2014;Sattayasai et al, 2012;Tay et al, 2014) Trees, 1998)). In response to this situation, sustainable agarwood planting and management with artificial induction of agarwood resin formation have been implemented.…”

Pharmacological Effects of Aquilaria spp. Leaves and Their Chemical Constituents

“…As mentioned earlier, A. sinensis is reported to activate AMPK in order to reduce the fasting blood glucose and glycosylated hemoglobin levels in db/db mice, consequently resulting in an ameliorating effect on insulin resistance (Jiang et al 2011 ). Mangiferin is reported to activate AMPK in L6 myotubes in vitro (Wang et al 2014 ).…”

“…In this model, A. sinensis is reported to have a thiazolidinedione (TZD)-like activity to activate AMPK (Jiang et al 2011 ).…”

“…Aquilaria sinensis is reported to reduce fasting blood glucose and glycosylated hemoglobin levels in db/db mice with ameliorating effect on insulin resistance (Jiang et al 2011 ). In this model, A. sinensis is reported to have a thiazolidinedione (TZD)-like activity to activate AMPK (Jiang et al 2011 ).…”

“…other than the laxative effects have been reported, such as antibacterial activity (Kamonwannasit et al 2013 ), inhibition of nitric oxide production , antihyperglycemic activity in db / db mice (Jiang et al 2011 ), antinociceptive effect (Zhou et al 2008 ), alpha-glucosidase inhibitory activity , analgesic activity (Sattayasai M. Kakino • H. Hara (*) Molecular Pharmacology, Department of Biofunctional Evaluation , Gifu Pharmaceutical University , Gifu 501-1196 , Japan e-mail: hidehara@gifu-pu.ac.jp et al 2012 ), and acetylcholinesterase inhibitory activity (Bahrani et al 2014 ). To confi rm the laxative effect of compounds from these tree species, we performed fi ve trials in humans and found that an extract of Aquilaria crassna had a laxative effect in individuals with a tendency toward constipation.…”