Effects of 8-methoxypsoralen on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice

Feng, Mei; Zhang, Hongtu; Cao, Baojun; Shuaidong, Liu; Mao, Jian; Zhang, Qidong

doi:10.1016/j.dmpk.2015.06.001

Cited by 4 publications

(2 citation statements)

References 25 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, 8-MOP in the diet of post-initiation phase does not prevent mouse lung carcinogenesis [ 107 ]. This effect is also confirmed in C57BL/6 mice that are induced by NNK [ 39 ]. In conclusion, 8-MOP is a strong chemopreventive agent for NNK-induced lung tumorigenesis.…”

Section: Chemoprevention Of Lung Cancer By Dietary Phytochemicalsmentioning

confidence: 59%

Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

et al. 2023

View full text Add to dashboard Cite

Lung cancer is the second most common cancer in the world. Cigarette smoking is strongly connected with lung cancer. Benzo[a]pyrene (BaP) and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-butanone (NNK) are the main carcinogens in cigarette smoking. Evidence has supported the correlation between these two carcinogens and lung cancer. Epidemiology analysis suggests that lung cancer can be effectively prevented through daily diet adjustments. This review aims to summarize the studies published in the past 20 years exploring dietary phytochemicals using Google Scholar, PubMed, and Web of Science databases. Dietary phytochemicals mainly include medicinal plants, beverages, fruits, vegetables, spices, etc. Moreover, the perspectives on the challenges and future directions of dietary phytochemicals for lung cancer chemoprevention will be provided. Taken together, treatment based on the consumption of dietary phytochemicals for lung cancer chemoprevention will produce more positive outcomes in the future and offer the possibility of reducing cancer risk in society.

show abstract

Section: Chemoprevention Of Lung Cancer By Dietary Phytochemicalsmentioning

confidence: 59%

Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The level of ROS (Yang, Xiong, Luo, Yang, & Xi, 2015) and enzyme activity all had an impact on cell viability. XAT reduces cell viability and interferes with cell division through the mitochondrial apoptotic pathway, while generating ROS and inhibiting the EPK1/2 pathway to interfere with cell metabolism (Feng et al, 2015). In addition, Cytochrome P450 2A5 (CYP2A5) activity is also related to tumor cell proliferation (Kim, Shin, Park, Kim, & Shin, 2016), and CYP2A5 can prevent 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK)‐induced tumorigenesis in mice by blocking NNKɑ hydroxylation (Feng et al, 2015).…”

Section: Pharmacological Effects Of Xanthotoxinmentioning

confidence: 99%

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Zhong

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

Xanthotoxin (XAT) is a natural furanocoumarins, a bioactive psoralen isolated from the fruit of the Rutaceae plant Pepper, which has received increasing attention in recent years due to its wide source and low cost. By collecting and compiling literature on XAT, the results show that XAT exhibits significant activity in the treatment of various diseases, including neuroprotection, skin repair, osteoprotection, organ protection, anticancer, antiinflammatory, antioxidative stress and antibacterial. In this paper, we review the pharmacological activity and potential molecular mechanisms of XAT for the treatment of related diseases. The data suggest that XAT can mechanistically induce ROS production and promote apoptosis through mitochondrial or endoplasmic reticulum pathways, regulate NF‐κB, MAPK, JAK/STAT, Nrf2/HO‐1, MAPK, AKT/mTOR, and ERK1/2 signaling pathways to exert pharmacological effects. In addition, the pharmacokinetics properties and toxicity of XAT are discussed in this paper, further elucidating the relationship between structure and efficacy. It is worth noting that data from clinical studies of XAT are still scarce, limiting the use of XAT in the clinic, and in the future, more in‐depth studies are needed to determine the clinical efficacy of XAT.

show abstract

Brain distribution and metabolic profiling of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats investigated by UHPLC-HRMS/MS following peripheral administration

et al. 2023

View full text Add to dashboard Cite

Effects of 8-methoxypsoralen on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice

Cited by 4 publications

References 25 publications

Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Brain distribution and metabolic profiling of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats investigated by UHPLC-HRMS/MS following peripheral administration

Contact Info

Product

Resources

About