Effects of 8-Arginine Vasotocin on Plasma Prolactin and Follicle-Stimulating Hormone Surges in the Proestrous Rat

Cheesman, Dean W.; Osland, Robert B.; Forsham, Peter H.

doi:10.3181/00379727-156-39938

Cited by 9 publications

(4 citation statements)

References 11 publications

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“…However, on the basis of these results in the male rat, and considering the results of Salisbury et al (1979), one could hypothesize that Cheesman et al (1977a), who reported AVT to completely suppress the preovulatory surge, were measuring plasma levels of prolactin at times following infusion when only the inhibitory effects of AVT were expressed. (Assuming that they employed the same protocol as in their earlier report [Cheesman et al, 1977b], blood sampling first occurred 30 min following treatment with 1 pg AVT.…”

Section: Discussionmentioning

confidence: 99%

“…AVT treatment resulted in acutely elevated plasma prolactin levels in intact and pinealectomized estrogen-progesterone (EP)-treated male rats Vaughan et al, 1976), normal (untreated with steroid) male rats ( Vaughan et al, 1977), EP-treated ovariectomized adult rats and pregnant mare serum (PMS)-treated immature female rats (Johnson, 1978). However, an inhibitory effect of AVT on prolactin release is suggested by its ability to block the preovulatory increase in plasma prolactin in cannulated adult (Cheesman et al, 1977a) and unanesthetized PMS-treated immature rats (. Johnson etal., 1978), totally and partially, respectively.…”

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confidence: 99%

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Acute Effects of Arginine Vasotocin on Plasma and Pituitary Levels of Prolactin in the Male Rat: Influence of Urethane Anesthesia

Johnson¹,

Vaughan²,

Reíter³

et al. 1980

Horm Res

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The acute effects of arginine vasotocin (AVT), a putative pineal peptide, on plasma levels of prolactin were investigated in the unanesthetized, estrogen-progesterone-treated male rat. A 10-µg s.c. injection resulted in significantly increased levels of prolactin while a 1-µg injection depressed plasma levels of this hormone; an inhibition of release was further suggested by increased levels of pituitary prolactin in rats treated with the lower dose. The same dose administered subcutaneously to urethane-anesthetized rats had no significant effect on plasma prolactin titers while a 10-µg dose was still stimulatory. In anesthetized rats, no dose of the AVT administered (1 ng to 10 µg, s.c, or 1 fg to 1 µg, i.v.) resulted in inhibition of prolactin release. In the unanesthetized normal male rat, 5 µg AVT first increased and then decreased levels of prolactin. Urethane anesthesia appears to mask an inhibitory effect of AVT on plasma prolactin levels in these animal preparations. Since AVT is capable of decreasing plasma prolactin levels, this peptide might be involved in the depression of plasma prolactin levels which appears to (at least partially) mediate pineal-induced gonadal degeneration.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Acute Effects of Arginine Vasotocin on Plasma and Pituitary Levels of Prolactin in the Male Rat: Influence of Urethane Anesthesia

Johnson¹,

Vaughan²,

Reíter³

et al. 1980

Horm Res

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“…Two experiments on the female rat provide contradictory results. Cheesman et al (1977b) found that oxytocin had no effect on the natural prolactin surge in pro-oestrous rats, whereas Salisbury et al (1980) induced prolactin release by steroid treatment of ovariectomized rats and found that oxytocin infusion (1 µg intra-atrially) augmented the surge. The work by Lumpkin et al (1983) provides considerable support for the view that oxytocin does affect prolactin secretion.…”

Section: Endogenous Gonadotrophinsmentioning

confidence: 99%

REVIEW Possible actions of gonadal oxytocin and vasopressin

Wathes¹

1984

Reproduction

105

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“…It has also been reported that the pineal gland is involved in the regulation of pituitary prolactin levels in the female rat (Donofrio «fe Reiter, 1972;Relkin, Adachi «fe Kahan, 1972), that pinealectomy blocks a nocturnal surge of plasma prolactin in the male rat (Ronnekliev, Krulich & McCann, 1973), and that melatonin (Kamberi, Mical «fe Porter, 1971) and arginine-vasotocin (Cheesman, Osland <& Forsham, 1977), two putative pineal hormones, are involved in the regulation of secretion of prolactin. In addition, pineal activity is theoretically enhanced by olfactory bulbectomy (Reiter, Sorrentino & Ellison, 1970) or by a short photoperiod (Reiter, 1973).…”

Section: Introductionmentioning

confidence: 94%

Influence of the Pineal Gland, Olfactory Bulbs and Photoperiod on Surges of Plasma Prolactin in the Female Rat

Pieper¹,

Gala

1979

Journal of Endocrinology

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The role of the pineal gland, olfactory bulbs and photoperiod in the regulation of the two daily surges of plasma prolactin in the pseudopregnant rat has been investigated. Pinealectomy had no effect on the surges of prolactin in pseudopregnant rats maintained on either a long (14 h light : 10 h darkness; 14L : 10D) or a short (2L : 22D) photoperiod, but olfactory bulbectomy decreased the nocturnal surge in animals maintained on 14L : 10D. This effect of bulbectomy was eliminated if the rats maintained on 14L : 10D were also pinealectomized. After cervical stimulation, bulbectomized rats maintained on a 2L : 22D photoperiod had nocturnal-type prolactin surges similar to those of intact rats maintained on the same photoperiod. These results indicate that the pineal gland andlength of photoperiod are not involved in the regulation of the surges of plasma prolactin in pseudopregnant rats but that the olfactory bulbs may enhance the nocturnal surge.

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Effects of 8-Arginine Vasotocin on Plasma Prolactin and Follicle-Stimulating Hormone Surges in the Proestrous Rat

Cited by 9 publications

References 11 publications

Acute Effects of Arginine Vasotocin on Plasma and Pituitary Levels of Prolactin in the Male Rat: Influence of Urethane Anesthesia

Acute Effects of Arginine Vasotocin on Plasma and Pituitary Levels of Prolactin in the Male Rat: Influence of Urethane Anesthesia

REVIEW Possible actions of gonadal oxytocin and vasopressin

Influence of the Pineal Gland, Olfactory Bulbs and Photoperiod on Surges of Plasma Prolactin in the Female Rat

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