Effects of 8,000 IU aXa long-term prophylaxis with certoparin on the incidence of hyperkalemia in patients with coronary heart disease – a post-hoc analysis of the PARAT trial

Melzer, Nima; Bramlage, Peter; Michaelis, Hans-Christoph

doi:10.1186/1756-0500-7-880

Cited by 1 publication

(2 citation statements)

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“…Melzer et al. [13] reported 12 cases of hyperkalemia. However, this was likely attributed to other medications, as the patients were also taking ACE inhibitors and NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

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Heparin‐induced hyperkalemia, can LMWH cause hyperkalemia? A systematic review

Amdetsion,

Gudeta,

Lumley

et al. 2023

eJHaem

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Hyperkalemia, an elevated blood potassium concentration exceeding 5.0 mEq/L, is associated with adverse outcomes and is frequently observed in hospitalized patients. Drug‐induced hyperkalemia accounts for a significant proportion of cases, with heparin, commonly used for venous thrombosis prevention, suspected to contribute, though less recognized than other heparin‐related side effects. Both unfractionated heparin (UFH) and low molecular weight heparin (LMWH) have been implicated in inducing hyperkalemia, primarily through the suppression of aldosterone levels and modulation of angiotensin II receptors. This systematic review examines the relationship between heparin, particularly LMWH, and hyperkalemia. Thirteen studies involving 1407 patients were analyzed. Findings indicated a lack of highquality evidence, with no significant increase in potassium levels associated with LMWH use. LMWH did not exhibit a dose‐response relationship with hyperkalemia incidence. Additionally, mechanisms underlying the hypothetical LMWHinduced hyperkalemia remained inconclusive. While this suggests that LMWH is unlikely to be a primary cause of hyperkalemia, caution is warranted, especially in patients with elevated baseline potassium levels.

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“…Melzer et al. [13] reported 12 cases of hyperkalemia. However, this was likely attributed to other medications, as the patients were also taking ACE inhibitors and NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

“…ACE inhibitor use and baseline potassium were linked in their analysis. Melzer et al [13], reported 10 cases of hyperkalemia, however it was probably linked to the other drugs as the patients were taking ACE inhibitors, and NSAIDS Rocha et al [18] found no hyperkalemia with bemparin but 4 cases with UFH. Koren-Michowitz et al…”

Section: Potassiummentioning

confidence: 99%