Effects of 660 nm low-level laser therapy on muscle healing process after cryolesion

Rodrigues, Natália Camargo; Assis, Lívia; Fernandes, Kelly Rossetti; Magri, Angela Maria Paiva; Ribeiro, Daniel Araki; Brunelli, Roberta de Matos; Abreu, Daniela Cristina Carvalho de; Rennó, Ana Cláudia Muniz

doi:10.1682/jrrd.2012.08.0147

Cited by 17 publications

(13 citation statements)

References 38 publications

(51 reference statements)

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“…Laser photobiostimulation with a wavelength of 830 nm at 4 J/cm 2 of damaged tibialis anterior muscles in rabbits effectively reduced inflammation in the injured tissue, and significantly increased the level of myogenin in the treatment group compared to the control group (Pertille et al 2012). Similar results were obtained by Rodrigues et al (2013), who exposed damaged tibialis anterior muscles in rats with a wavelength of 660 nm at 10 J/cm 2 and 50 J/cm 2 . Both and Rodrigues et al (2014) demonstrated that LLLT reduces immunoexpression of COX-2 in damaged muscles, thus decreasing the severity of inflammation and facilitating tissue repair processes.…”

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confidence: 73%

The use of laser biostimulation in human and animal physiotherapy – a review

et al. 2017

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Laser biostimulation involves applying a laser beam to the tissue to facilitate healing and regenerative processes. Laser therapy is one of the most important physical methods used in human physiotherapy. In veterinary medicine, laser therapy is a new and so far poorly examined method. The results of studies conducted so far are very promising, yet the positive effect of laser light, especially that of class IV, has yet to be confirmed. This article presents an overview of the available literature on the effect of laser treatment on the human and animal organism. Low level laser therapy (LLLT), high intensity laser therapy (HILT), physical therapy

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confidence: 73%

The use of laser biostimulation in human and animal physiotherapy – a review

et al. 2017

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“…In this context, the clinical demand for therapeutic strategies to promote bone repair has been growing in recent years in direct relation to the increase on the human population [4]. One of the most promising treatments is the use of low-level laser therapy (LLLT), which is able of reestablishing cellular homeostasis and regenerating biological tissues, such as the muscle, tendons, cartilage, and bone [1,[5][6][7][8][9].…”

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confidence: 99%

Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis

et al. 2015

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This study evaluated the morphological changes produced by LLLT on the initial stages of bone healing and also studied the pathways that stimulate the expression of genes related to bone cell proliferation and differentiation. One hundred Wistar rats were divided into control and treated groups. Noncritical size bone defects were surgically created at the upper third of the tibia. Laser irradiation (Ga-Al-As laser 830 nm, 30 mW, 94 s, 2.8 J) was performed for 1, 2, 3, 5, and 7 sessions. Histopathology revealed that treated animals produced increased amount of newly formed bone at the site of the injury. Moreover, microarray analysis evidenced that LLLT produced a significant increase in the expression TGF-β, BMP, FGF, and RUNX-2 that could stimulate osteoblast proliferation and differentiation, which may be related to improving the deposition of newly formed bone at the site of the injury. Thus, it is possible to conclude that LLLT improves bone healing by producing a significant increase in the expression of osteogenic genes.

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“…Many authors have demonstrated that LLLT is able to reduce the oxidative and nitrative stress on muscle tissue, and that it can modulate the inflammatory processes in muscle tissue in rats [17,18]. Furthermore, laser irradiation has been shown to increase the expression of genes related to muscle cell differentiation such as MyoD and myogenin [19].…”

Section: Introductionmentioning

confidence: 99%

Laser therapy modulates systemic inflammatory processes and muscle atrophy in an experimental model of sepsis in rats

Assis

Rennó

Bublitz

et al. 2015

Photonics &Amp; Lasers in Medicine

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Objective: The aim of this study was to determine the effectiveness of low-level laser therapy (LLLT) on the modulation of the systemic inflammatory processes and skeletal muscle morphology in an experimental sepsis model (cecal ligation and puncture, CLP). Study design: Seventy-two male Wistar rats were randomly divided into three groups: control group (CG); sepsis group (SG) where rats were submitted to CLP but without LLLT treatment, and the sepsis laser-treated group (SLG). Laser irradiation (GaAlAs laser, continuous wave, 808 nm, 30 mW, 48 s, 30 J/cm 2 , 0.028 cm 2 , 1.07 mW/cm 2 ) was performed immediately after surgery and every 24 h at 4 points (on the middle of tibialis anterior and diaphragm, bilaterally), through the punctual contact technique. All sepsis animals were sacrificed at 6, 24, 48 and 72 h postsurgery. The immunohistochemistry analysis was used to verify the expression of proteins related to the regulation of muscle wasting (MuRF-1 and atrogin). In order to investigate the action of LLLT on inflammatory mediators in the rat sepsis model, two inflammatory cytokines IL-6 and IL-10, were evaluated. Results:The results showed that the laser-treated animals presented a lower IL-6 activity and decreased atrogin and MuRF-1 immunoexpression. However, no difference was observed in muscle cross-sectional area between the experimental groups. Conclusion: These results suggest that LLLT was able to decrease the systemic inflammation and muscle atrophy markers, preventing muscle protein degradation. Zusammenfassung Zielsetzung: Ziel dieser Studie war es, die Wirksamkeit der Low-Level-Laser-Therapie (LLLT) auf die Modulation der systemischen Entzündungsprozesse und Skelettmuskel-Morphologie in einem experimentellen Sepsismodell (Blinddarm-Ligation und Punktions-induzierte Sepsis, CLP) zu untersuchen. Studiendesign: 72 männliche Wistar-Ratten wurden nach dem Zufallsprinzip in drei Gruppen eingeteilt: Kontrollgruppe (CG); Sepsis-Gruppe (SG) mit Ratten, die einer CLP aber keiner LLLT-Behandlung unterzogen wurden; und Sepsis + Laser-behandelte Gruppe (SLG). Die Laserbestrahlung (kontinuierlich abstrahlender GaAlAs-Laser mit 808 nm, 30 mW, 48 s, 30 J/cm 2 , 0,028 cm 2 , 1.07 mW/cm 2 ) erfolgte mittels punktueller Kontakttechnik Brought to you by | Kungliga Tekniska Högskolan Authenticated Download Date | 8/8/15 7:21 AM 242 L. Assis et al.: Laser therapy modulates systemic inflammatory processesunmittelbar nach der Operation und alle 24 h an 4 ausgewählten Punkten (in der Mitte des M. tibialis anterior und Zwerchfell, bilateral). Alle Sepsis-Tiere (Gruppen SG und SLG) wurden 6, 24, 48 und 72 h nach der Operation euthanasiert. Zur Verifizierung der Expression der mit der Regulierung von Muskelschwund in Verbindung stehenden Proteine (MuRF-1 und Atrogin) wurde die immunhistochemische Analyse verwendet. Um die Wirkung der LLLT auf die Entzündungsmediatoren im Ratten-Sepsismodell zu untersuchen, wurden zwei inflammatorische Zytokine (IL-6 und IL-10) evaluiert. Ergebnisse: Im Ergebnis wurde bei den Laser-behandelten...

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Effects of 660 nm low-level laser therapy on muscle healing process after cryolesion

Cited by 17 publications

References 38 publications

The use of laser biostimulation in human and animal physiotherapy – a review

The use of laser biostimulation in human and animal physiotherapy – a review

Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis

Laser therapy modulates systemic inflammatory processes and muscle atrophy in an experimental model of sepsis in rats

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