Effects of 6 weeks of n-3 fatty acids and antioxidant mixture on lipid peroxidation at rest and postexercise

Abstract

The purpose of this randomized study was to measure the influence of 6 weeks of LCPUFA (600 mg EPA and 400 mg DHA per day) supplementation alone or in association with 30 mg vitamin E, 60 mg vitamin C and 6 mg β-carotene on resting and exercise-induced lipid peroxidation in judoists (n = 36). Blood samples were collected at rest before (T (1)) and after the supplementation period, in preexercise (T (2)) and postexercise (T (3)) conditions, for analysis of α-tocopherol, retinol, lag phase (Lp) before free radical-induced oxidation, maximum rate of oxidation (R (max)) during the propagating chain reaction, maximum amount of conjugated dienes (CD(max)) accumulated after the propagation phase, and nitric oxide, malondialdehyde and lipoperoxide (POOL) concentrations. Dietary data were collected using a 7-day diet record. There were no significant differences among treatment groups with respect to habitual intakes of energy from fat, carbohydrate, or protein. At T (1), there were no significant differences among treatment groups with respect to lipid peroxidation, lag phase, and levels of α-tocopherol or retinol. The consumption of an n-3 LC PUFA supplement increased oxidative stress at rest and did not attenuate the exercise-induced oxidative stress. The addition of antioxidants did not prevent the formation of oxidation products at rest. On the contrary, it seems that the combination of antioxidants added to the n-3 LCPUFA supplement led to a decrease in, CD(max), R (max), and POOL and MDA concentrations after a judo training session.

The ethanol extract from the rhodophyta Gloiopeltis furcata and its active ingredient docosahexaenoic acid improve exercise performance in mice

“…In untrained healthy individuals, even low doses of n ‐3 PUFA provided partial protection against the SOD reduction after exercise and improved catalase activity during recovery compared with placebo (Poprzecki, Zajac, Chalimoniuk, Waskiewicz, & Langfort, ). Moreover, n ‐3 PUFA supplementation led to decrements in the malondialdehyde and lipoperoxide concentrations after a judo training session (Filaire et al, ). Collectively, recent studies suggest that DHA‐enriched beverages might improve physical performance indirectly by favoring post‐exercise recovery, reducing cellular oxidative damage, and counteracting the production of pro‐inflammatory molecules associated with organ damage (Orrù et al, ).…”

Levothyroxine and lung cancer in females: the importance of oxidative stress

“…Unfortunately the study was aimed at man only, though the increase in death for gastric cancer was significantly related to high polyunsaturated fatty acid (PUFA) intake that increase oxidative stress [13]. …”

Omega-3 Polyunsaturated Fatty Acids in Physical Performance Optimization

“…They concluded that the beneficial effect of omega-3 PUFA supplementation during endurance exercise may be attributable to the activation of the superoxide dismutase and catalase pathways. On the other hand, Filaire et al (2011) recently showed that 6 weeks of daily supplementation with 600 mg EPA and 400 mg DHA increased oxidative stress at baseline in trained men and did not attenuate the increased oxidative stress resulting from exercise (cycling exercise to exhaustion). Addition of antioxidants (30 mg vitamin E, 60 mg vitamin C, and 6 mg β-carotene) to the diet did not prevent the formation of oxidation products at rest.…”