Effects of 6 Months of Active Commuting and Leisure-Time Exercise on Fibrin Turnover in Sedentary Individuals with Overweight and Obesity: A Randomised Controlled Trial

Gram, Anne Sofie; Petersen, Morten Krogh; Quist, Jonas Salling; Rosenkilde, Mads; Stallknecht, Bente; Bladbjerg, Else‐Marie

doi:10.1155/2018/7140754

Cited by 15 publications

(26 citation statements)

References 51 publications

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“…Changes in VO 2 peak and body composition in GO-ACTIWE have been reported elsewhere [15–18]. For the participants included in the present analysis, VO 2 peak increased in all three intervention groups at 6 months ( p ≤ 0.01 vs. CON), while body weight and body fat percentage decreased ( p ≤ 0.02 vs. CON) (data not shown).…”

Section: Resultssupporting

confidence: 65%

“…Duration of exercise sessions was on average 46 min in BIKE, 54 min in MOD, and 37 min in VIG. Training compliance in GO-ACTIWE including a slightly different number of participants has been reported elsewhere [15–18]. 95% of all accelerometer measurements covered 6–7 days and nights (Table 3).…”

Section: Resultsmentioning

confidence: 89%

“…The results on fat loss [15], appetite [16], low-grade inflammation and endothelial function [17], and fibrin turnover [18] in GO-ACTIWE have been reported elsewhere. We followed the methods previously described in details in Rosenkilde et al [14] and Quist et al [15], but in order to facilitate reading, we present a detailed description of the methodology relevant for the present analysis.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Exercise Domain and Intensity on Sleep in Women and Men with Overweight and Obesity

et al. 2019

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Inadequate sleep is associated with cardiometabolic risk and adiposity. Exercise has been suggested as an efficient strategy to improve sleep; however, the effects of different types of exercise on sleep in individuals with overweight and obesity are not well understood. We examined effects of active commuting and leisure-time exercise on sleep in individuals with overweight or obesity. 130 physically inactive adults (20–45 years) with overweight or class 1 obesity (body mass index: 25–35 kg/m2) were randomized to 6 months of habitual lifestyle (CON, n = 18), active commuting by bike (BIKE, n = 35), or leisure-time exercise of moderate intensity (MOD, 50% VO2peak-reserve, n = 39) or vigorous intensity (VIG, 70% VO2peak-reserve, n = 38), 5 days/week. Sleep was assessed from 7-day/night accelerometry and questionnaires at baseline, 3 months, and 6 months. 92 participants were included in a per protocol analysis. At 3 months, sleep duration was longer in VIG (29 min/night [3; 55] (mean [95% CI]), p=0.03) but not in BIKE and MOD (p≥0.11) compared with CON and was not different between groups at 6 months (p≥0.36 vs. CON). At 6 months, sleep duration variability was lower in MOD (−31% [−50; −3], p=0.03) and numerically lower in VIG (−28% [−49; 1], p=0.06) relative to CON but was unchanged in BIKE (p=0.17 vs. CON). The effects were, however, primarily attributable to shorter and more irregular sleep in CON over time. Our findings suggest that effects of exercise on sleep in individuals with overweight and obesity may be restricted to leisure-time exercise with a short-term effect on sleep duration after vigorous intensity exercise (3 months) but a more regular sleep pattern after 6 months of moderate and vigorous intensity exercise compared with physically inactive controls. This trial was registered at clinicaltrials.gov with ID NCT01962259.

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Section: Resultssupporting

confidence: 65%

Section: Resultsmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

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Effects of Exercise Domain and Intensity on Sleep in Women and Men with Overweight and Obesity

et al. 2019

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“…A comprehensive description of the interdisciplinary study design has been published 35 along with data on fat loss, 36 low-grade inflammation, 37 blood lipids and fibrin turnover. 38 We initially planned a 12-month intervention, but on 2 February 2014 the intervention was reduced to 6 months due to recruitment issues and an unexpectedly large withdrawal of eligible individuals during the run-in period. The study adhered to the declaration of Helsinki and written informed consent was obtained from all participants before inclusion.…”

Section: Methods Study Designmentioning

confidence: 99%

How does 6 months of active bike commuting or leisure-time exercise affect insulin sensitivity, cardiorespiratory fitness and intra-abdominal fat? A randomised controlled trial in individuals with overweight and obesity

et al. 2019

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ObjectivesTo evaluate effects of active bike commuting or leisure-time exercise of two intensities on peripheral insulin sensitivity (primary outcome), cardiorespiratory fitness and intra-abdominal adipose tissue mass (secondary outcomes).Methods188 physically inactive, healthy women and men (20-45 years) with overweight or class 1 obesity were recruited. In the 6-month trial, 130 participants were randomised to either: no intervention (CON), active commuting (BIKE) or leisure-time exercise of moderate (MOD, 50% VO2peak) or vigorous (VIG, 70% VO2peak) intensity. 100 completed follow-up testing. Exercise prescription was 5 days/week with a weekly exercise energy expenditure of 1600 kcal for women and 2100 kcal for men. Testing was performed at baseline, 3 months and 6 months.ResultsPeripheral insulin sensitivity (ml/min/pmol insulin/L) increased (improved) by 24% (95% CI 6% to 46%, p=0.01) in VIG compared with CON at 3 months. Peripheral insulin sensitivity increased (improved) by 20% in BIKE (95% CI 1% to 43%, p=0.04) and 26% in VIG (95% CI 7% to 47%, p<0.01) compared with CON at 6 months. Cardiorespiratory fitness increased in all exercise groups compared with CON at 6 months; but the increase was higher in those that undertook vigorous exercise than those who did moderate exercise. Intra-abdominal adipose tissue mass diminished across all exercise groups in comparison to CON at 6 months.ConclusionsActive bike commuting improved cardiometabolic health; as did leisure-time exercise. Leisure-time exercise of vigorous intensity conferred more rapid effects on peripheral insulin sensitivity as well as additional effects on cardiorespiratory fitness than did moderate intensity exercise.Trial registrationNCT01962259

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“…63,64 Nonetheless, the influence of acute bouts of exercise on coagulation and fibrinolysis have often produced conflicting data due to various factors including varying study protocols and exercise modes. 62,[65][66][67][68][69] It is evident that exercise intensity plays an influential role in shifting the equilibrium between coagulation and fibrinolysis, with strenuous (high-intensity) exercise consistently demonstrated to increase hemostatic activation as opposed to low-to moderate-intensity exercise. 63,64,[70][71][72][73] For apparently healthy individuals, exercise completed at a higher intensity appears to increase clot degradation, probably in response to coagulation activity.…”

Section: Exercise and Hemostasismentioning

confidence: 99%

Coronavirus (COVID-19), Coagulation, and Exercise: Interactions That May Influence Health Outcomes

Zadow

Wundersitz

Hughes

et al. 2020

Semin Thromb Hemost

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The proinflammatory cytokine storm associated with coronavirus disease 2019 (COVID-19) negatively affects the hematological system, leading to coagulation activation and endothelial dysfunction and thereby increasing the risk of venous and arterial thrombosis. Coagulopathy has been reported as associated with mortality in people with COVID-19 and is partially reflected by enhanced D-dimer levels. Poor vascular health, which is associated with the cardiometabolic health conditions frequently reported in people with severer forms of COVID-19, might exacerbate the risk of coagulopathy and mortality. Sedentary lifestyles might also contribute to the development of coagulopathy, and physical activity participation has been inherently lowered due to at-home regulations established to slow the spread of this highly infectious disease. It is possible that COVID-19, coagulation, and reduced physical activity may contribute to generate a “perfect storm,” where each fuels the other and potentially increases mortality risk. Several pharmaceutical agents are being explored to treat COVID-19, but potential negative consequences are associated with their use. Exercise is known to mitigate many of the identified side effects from the pharmaceutical agents being trialled but has not yet been considered as part of management for COVID-19. From the limited available evidence in people with cardiometabolic health conditions, low- to moderate-intensity exercise might have the potential to positively influence biochemical markers of coagulopathy, whereas high-intensity exercise is likely to increase thrombotic risk. Therefore, low- to moderate-intensity exercise could be an adjuvant therapy for people with mild-to-moderate COVID-19 and reduce the risk of developing severe symptoms of illness that are associated with enhanced mortality.

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Effects of 6 Months of Active Commuting and Leisure-Time Exercise on Fibrin Turnover in Sedentary Individuals with Overweight and Obesity: A Randomised Controlled Trial

Cited by 15 publications

References 51 publications

Effects of Exercise Domain and Intensity on Sleep in Women and Men with Overweight and Obesity

Effects of Exercise Domain and Intensity on Sleep in Women and Men with Overweight and Obesity

How does 6 months of active bike commuting or leisure-time exercise affect insulin sensitivity, cardiorespiratory fitness and intra-abdominal fat? A randomised controlled trial in individuals with overweight and obesity

Coronavirus (COVID-19), Coagulation, and Exercise: Interactions That May Influence Health Outcomes

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