Effects of 6-hydroxydopamine lesioning of the medial prefrontal cortex on social interactions in adolescent and adult rats

Li, Chunrong; Huang, Guang‐Biao; Sui, Zhi Yan; Han, Eui-Hyeog; Chung, Young‐Chul

doi:10.1016/j.brainres.2010.05.064

Cited by 24 publications

(23 citation statements)

References 31 publications

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“…Li et al, 2010). Thus this 6-OHDA and PIP animal model may then be considered viable to examine negative and not solely cognitive symptoms of schizophrenia (Balci et al, 2010b;Simpson et al, 2011;Ward 2009).…”

Section: Discussionmentioning

confidence: 99%

“…One reason for the lack of a significant difference could be that the dose of 6-OHDA infused was not high enough; other studies such as the study by Li et al (2010) used a higher dose and obtained clearer differences after processing neural tissue. Another factor that may account for the lack of consistency between groups in this respect is the number of rats included in each group.…”

Section: Discussionmentioning

confidence: 99%

“…This lesion model in which 6-OHDA is infused in the mPFC, has contributed to the generation of a modified DA hypothesis for schizophrenia. More specifically in this 6-OHDA model, the depletion of dopaminergic neurons reaches the ventral tegmental area destroying the DA mesocortical system and in turn increases levels of DA in the striatum and nucleus accumbens (NAC) (Li et al, 2010). Li et al (2010) performed bilateral infusions of 6-OHDA in the mPFC of adolescents rats and adult rats and found a significant decrease in grooming and social behavior.…”

Section: Introductionmentioning

confidence: 99%

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6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure.

Elcoro¹,

Thompson²,

Kelly³

et al. 2014

Psychology & Neuroscience

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Impaired temporal control is symptomatic of several neurological disorders; recently, it has been implicated in schizophrenia. An animal model of schizophrenia using 6-hydroxydopamine (6-OHDA) infused to the medial pre-frontal cortex (mPFC) was employed to examine its effects on temporal control. Twelve rats were trained on a peak-interval procedure (PIP) until stable patterns of behavior were obtained. Rats infused with 6-OHDA responded less during peak trials and their peak functions were flatter than sham rats. These results are consistent with similar studies with transgenic mice with increased striatal dopamine D2 receptor activity. Lesions in the mPFC decreased motivation to respond in a PIP. These effects may be considered analogous to negative symptoms of schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure.

Elcoro¹,

Thompson²,

Kelly³

et al. 2014

Psychology & Neuroscience

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“…Play, a rewarding behavior, may be dependent on the levels of dopamine in the PFC, a region associated with the processing of rewards [46]. In addition, the excitation of metabotropic dopamine receptors alters the spine density through the activation of several cell signaling pathways (reviewed by Dietz et al [47]).…”

Section: Discussionmentioning

confidence: 99%

Mild Prenatal Stress-Modulated Behavior and Neuronal Spine Density without Affecting Amphetamine Sensitization

Muhammad

Kolb²

2011

Dev Neurosci

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The present study investigated the effect of prenatal stress (PS) on juvenile behavior and adult amphetamine (AMPH) sensitization, as well as the effect of the interaction between experience (i.e. PS) and drug (i.e. AMPH) on cortical thickness and neuronal morphology in corticolimbic regions in rats. Juvenile male and female rats, exposed to gestational stress, were tested in behavioral tasks that included open field locomotion, elevated plus maze, novel object recognition, and play fighting behavior. The development and persistence of drug-induced behavioral sensitization in adults were tested by chronic AMPH administration and challenge, respectively. Spine density in corticolimbic regions was examined for structural plasticity. The findings showed that PS produced anxiety-like behavior in males. Furthermore, PS in males resulted in female-like play and enhanced partial rotation defense, whereas in females PS increased the probability of evasion in response to an attack. AMPH administration resulted in gradual increase in behavioral sensitization that persisted at least for 2 weeks; however, PS did not influence AMPH-induced behavioral sensitization in either male or female rats. Moreover, PS increased the spine density in the nucleus accumbens (NAc) and decreased it in the medial prefrontal cortex (mPFC) without any alteration in the orbital frontal cortex (OFC). Similarly, AMPH administration increased spine density in the NAc and mPFC, whereas a decrease was observed in the OFC. However, PS prevented the drug-induced alterations in the spine density observed in controls. In sum, PS modulated juvenile behavior and altered brain morphology without influencing AMPH-induced behavioral sensitization substantially.

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“…Also, loss of oligodendrocyte ErbB signaling by DN-ErbB4 produces changes in dopamine neurotransmission similar to those generated by juvenile isolation (21, 29). Thus, a second possibility is that myelin defects caused by isolation change dopaminergic functionand contribute to the deficits in working memory and social interactions (30, 31). Although the changes in NRG1 expression induced by isolation might also modify ErbB4 signaling in interneurons (32), because elimination of ErbB3 signaling in oligodendrocytes phenocopies isolation, it is evident that oligodendrocyte ErbB3 signaling is essential in this context.…”

mentioning

confidence: 99%

A Critical Period for Social Experience–Dependent Oligodendrocyte Maturation and Myelination

Makinodan

Rosen

Ito

et al. 2012

Science

761

790

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A Critical Period for Glia The brain develops in fits and starts—while one system is completed, another system may still be under construction. Such transient states are known as critical periods, and during these specific aspects of brain development may become more sensitive to outside agents than they would be later. Makinodan et al. (p. 1357 ) observed the effect of environmental conditions on the brains of mice bioengineered to develop fluorescent oligodendrocytes. The mice were exposed to a variety of social conditions during rearing, ranging from isolation to a normal laboratory cage setting, or to settings enriched with extra buddies and a steady rotation of new play toys. The results show that social isolation leaves a developmental trace that persists into adulthood. Specifically, they found that oligodendrocytes, which produce the myelin that insulates neurons, were underdeveloped, suggesting that there may be a critical period that governs development of these glial oligodendrocyte cells.

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Effects of 6-hydroxydopamine lesioning of the medial prefrontal cortex on social interactions in adolescent and adult rats

Cited by 24 publications

References 31 publications

6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure.

6-Hydroxydopamine lesions in the medial prefrontal cortex of rats exposed to a peak-interval procedure.

Mild Prenatal Stress-Modulated Behavior and Neuronal Spine Density without Affecting Amphetamine Sensitization

A Critical Period for Social Experience–Dependent Oligodendrocyte Maturation and Myelination

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