Effects of (-)-5-Vinyl-2-Oxazolidinethione on the Radioiodine Metabolism in Growing Chicks

Matsumoto, Tatsuro; Itoh, Hiroshi; Akiba, Yukio

doi:10.3382/ps.0481061

Cited by 11 publications

(4 citation statements)

References 20 publications

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“…An increase in MIT/DIT ratio, similar to that seen in this study, has been reported as a result of iodine deficiency, OZT, allylisothiocyanate, and 6-n"-propylthiouracil (Langer and Stolc 1965;Inoue and Taurog 1968;Matsumoto et al 1969;Socolow et al 1968 …”

Section: Dietssupporting

confidence: 69%

Effects of Various Dietary Glucosinolates on Growth, Feed Intake, and Thyroid Function of Rats

Lo¹,

Bell²

1972

Can. J. Anim. Sci.

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The glucosinolate form of 3-butenyl isothio-low iodine diets. Growth depression occurred cyanate (BNCS)G was compared in two ex-with dietary (BNCS)G levels of 2-? ^ele periments with rapeseed meal (RSM) gluco-diet. Less than half this amount of BNCS sinolates (including oxazolidinethione, (BNCS) gave similar effects. Thyroid enlargement was G, and (OZT)G), and with the hydroiyzed greatest when (OZT)G was fed. The glucocompounds 3-butenyl isothiocyanate (BNCS) sinolate (BNCS)G resulted in reduced proand 3-butenyl cyanide (BCN) combined. portions of triiodothyronine (*I-T") and thyThese were fed to rats for 21 days.

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Section: Dietssupporting

confidence: 69%

Effects of Various Dietary Glucosinolates on Growth, Feed Intake, and Thyroid Function of Rats

Lo¹,

Bell²

1972

Can. J. Anim. Sci.

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“…Detailed procedures for the determination of thyroidal 131 1 uptake, plasma PB 131 I and distribution of I3 ' I compounds in the gland were described in our previous papers (Matsumoto et al, 1969;Akiba and Matsumoto, 1971). Determined iodine content of the diet was 0.67 (j-g./g.…”

Section: Methodsmentioning

confidence: 99%

“…I N previous papers (Matsumoto et al, 1969;Akiba and Matsumoto, 1971), antithyroid effects of (-)-5-vinyl-2-oxazoIidinethione (goitrin), a naturally occurring goitrogen in plants of Brassica family, have been investigated in chicks. The relative activity of goitrin compared with synthetic goitrogen has been demonstrated in man and in the rat (Astwood et al, 1949;lino, 1961;and Faiman et al, 1967), but it has not yet been investigated in chicks.…”

mentioning

confidence: 99%

Antithyroid Activity of Goitrin in Chicks

Akiba

Matsumoto

1976

Poultry Science

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Antithyroid activity of orally administered goitrin was assessed by parallel-line assay in chicks using four indices. The relative potency of goitrin in chicks was estimated to be approximately 0.31 times the potency of PTU in causing enlargement of thyroid gland, 0.06 times in effect on depression in plasma thyroid hormone, and 0.08 times in inhibitory effects on biosynthesis of thyroid hormone in the gland. It might be concluded that thyroid hormone synthesis is not so much suppressed to the degree expected from the enlargement of thyroid gland when goitrin is administered orally to the chick.

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“…DDT, phénobarbital, aniline, dieldrin and aminopyrine were chemicals/drugs most studied in drug interactions. Specific in stances showed that goitrin and propylthio uracil affected the protein binding of sodium iodide in the thyroid and blood plasma in chickens (9) and that pretreatment with poly chlorinated hydrocarbons increases steroid metabolism in hens (2,11). Pretreatment of quail with different pesticides gave a variety of effects on barbiturate sleeping times (4).…”

Section: Drug Interactionsmentioning

confidence: 99%

Drug Metabolism in Birds

Pan

Fouts²

1979

Pharmacology

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Papers published over 100 years since the beginning of the scientific study of drug metabolism in birds were reviewed. Birds were found to be able to accomplish more than 20 general biotransformation reactions in both functionalization and conjugation. Chickens were the primary subject of study but over 30 species of birds were used. Large species differences in drug metabolism exist between birds and mammals as well as between various birds, these differences were mostly quantitative. Qualitative differences were rare. On the whole, drug metabolism studies in birds have been neglected as compared with similar studies on insects and mammals. The uniqueness of birds and the advantages of using birds in drug metabolism studies are discussed. Possible future studies of drug metabolism in birds are recommended.

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Effects of (-)-5-Vinyl-2-Oxazolidinethione on the Radioiodine Metabolism in Growing Chicks

Cited by 11 publications

References 20 publications

Effects of Various Dietary Glucosinolates on Growth, Feed Intake, and Thyroid Function of Rats

Effects of Various Dietary Glucosinolates on Growth, Feed Intake, and Thyroid Function of Rats

Antithyroid Activity of Goitrin in Chicks

Drug Metabolism in Birds

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