“…3,4 This pyrimidine base analog, when incorporated into DNA, conferred cytotoxicity, 5 genetic mutations, 6 and antiviral as well as antibacterial activities. 4,8 Cellular accumulation of hmU, presumably due to a decrease in excision-repair activity of hmU-DNA glycosylase, 9,10 was suggested to be responsible for adult progeria (Werner's syndrome, a rare autosomal recessive disorder). 4,8 Cellular accumulation of hmU, presumably due to a decrease in excision-repair activity of hmU-DNA glycosylase, 9,10 was suggested to be responsible for adult progeria (Werner's syndrome, a rare autosomal recessive disorder).…”