Effects of 5-HTP on sleep in mongol children

Petre-Quadens, O; Greef, Annemarie De

doi:10.1016/0022-510x(71)90211-5

Cited by 12 publications

(5 citation statements)

References 5 publications

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“…30–32,57 Petre-Quadens and de Greef 57 and Petre-Quadens and de Lee 30 reported on the effects of 5-hydroxytryptophan (5-HTP) on “quiet” (non-REM) and “paradoxical” (REM) sleep in children with DS. Based on earlier findings by Bazelon et al 58 who observed improvements in hypotonia, 5-HTP was administered to children with DS in a quasi-experimental study.…”

Section: Resultsmentioning

confidence: 99%

Sleep measurement and monitoring in children with Down syndrome: A review of the literature, 1960–2010

Churchill¹,

Kieckhefer²,

Landis³

et al. 2012

Sleep Medicine Reviews

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Section: Resultsmentioning

confidence: 99%

Sleep measurement and monitoring in children with Down syndrome: A review of the literature, 1960–2010

Churchill¹,

Kieckhefer²,

Landis³

et al. 2012

Sleep Medicine Reviews

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“…These histograms demonstrated that retardates v/ere particularly deficient in intervals under 1 sec; that is, they were deficient in eye movements occurring quickly in succession (within 1 sec of one another). In a second study (9), this finding was replicated in mongoloid infants; moreover, administration of 5-hydroxy tryptophan increased the number of intervals under 1 sec.…”

mentioning

confidence: 52%

The Temporal and Periodic Organization of REM Eye Movements in Mental Retardation

Krynicki¹

1976

Neuropsychobiology

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Time trends and periodic cycles in REM sleep eye movements were examined in 6 functional and 6 mongoloid adolescent retardates. Both groups of subjects showed approximately equal percentages of linear trends, quadratic trends, linear and quadratic trends, and absence of trend. The eye movement time-series were subject to an orthogonal spectral analysis. In both groups of subjects, peak spectral estimates generally occurred at 10.6- or 21.3-min periods. Following this, the eye movements of the longest REM periods (and one long period of pre-sleep wakefulness) were subject to a least-squares spectral analysis. This analysis yielded estimates ranging from 22 to 44 min. Eye movements lacked the ultradian organization previously reported for eye movements of normal subjects. These results imply that the ultradian organization of REM sleep and the ultradian organization of eye movements may be independent.

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“…Importance of 5-HT in DS is also a much discussed subject [21][22][23][24]. However, genetic polymorphisms in these neurotransmitters, in association with DS, have never been explored.…”

Section: Discussionmentioning

confidence: 98%

“…Reduced level of 5HT is a clinical characteristic of DS patients [21] and investigations on blood platelets isolated from DS patients and transgenic mice (harbouring human CuZnSOD gene) revealed reduced 5-HT uptake associated with overexpression of Cu-Zn superoxide dismutase gene [22]. Muscular tone, motor activity [23] and sleep abnormalities [24] observed in DS patients were reported to improve after administration of 5HT precursor, 5-hydroxytryptophan (5-HTP). However, treatment with 5-HTP was discontinued due to serious side effects.…”

Section: Introductionmentioning

confidence: 96%

Lack of Association Between Down Syndrome and Polymorphisms in Dopamine Receptor D4 and Serotonin Transporter Genes

et al. 2008

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Down Syndrome (DS) patients suffer from cognitive dysfunction, depression, hyperactivity, irritability etc. Dopamine (DA) and serotonin (5HT) are known to control cognitive and behavioral attributes. An increased number of the DA receptor 4 (DRD4) is detected in brain regions primarily involved in cognition. Impairments in executive function have also been reported with depletion in 5HT. A variable number of tandem repeat (VNTR) in the exon 3 of DRD4 and an insertion/deletion polymorphism in the promoter region of 5HT transporter (5HTTLPR) have been found to be associated with different neurobehavioral disorders; however, association of these polymorphisms with DS has never been explored. The present family-based analysis on DS revealed significant over-transmission of a DRD4 VNTR allele which encodes for D4 receptor with average activity. No association was noticed for the 5HTTLPR. We may conclude that these genetic polymorphisms are not contributing to the neuromotor and cognitive dysfunctions observed in DS.

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Effects of 5-HTP on sleep in mongol children

Cited by 12 publications

References 5 publications

Sleep measurement and monitoring in children with Down syndrome: A review of the literature, 1960–2010

Sleep measurement and monitoring in children with Down syndrome: A review of the literature, 1960–2010

The Temporal and Periodic Organization of REM Eye Movements in Mental Retardation

Lack of Association Between Down Syndrome and Polymorphisms in Dopamine Receptor D4 and Serotonin Transporter Genes

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