Effects of 5-aminolevulinic acid with iron supplementation on respiratory responses to graded cycling and interval walking training achievement in older women over 75 yrs

Ichihara, Yasuko; Masuki, Shizue; Uchida, Kôji; Takahashi, Kiwamu; Nakajima, Motowo; Nosé, Hiroshi

doi:10.1016/j.exger.2021.111356

Cited by 1 publication

(1 citation statement)

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“…Additionally, 5-ALA or its derivatives and ferric citrate compounds also are the main ingredient of disease prevention and improvement agent. A recent research demonstrated that 5-ALA combined with sodium ferric citrate could effectively improve aerobic capacity and voluntary exercise training achievement in older women over 75 years (Masuki et al, 2016;Ichihara et al, 2021). 5-ALA was also developed as a combined therapeutic-diagnostic agent in dentistry based on the strong dual modality of 5-ALA as lethal to cariogenic bacteria through photodynamic inactivation and enhancing LIF intensity for identification of dental caries (Lashkari et al, 2019).…”

Section: Photosensitizers and Cosmeticsmentioning

confidence: 99%

Natural 5-Aminolevulinic Acid: Sources, Biosynthesis, Detection and Applications

Jiang

Hong

Mao

et al. 2022

Front. Bioeng. Biotechnol.

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5-Aminolevulinic acid (5-ALA) is the key precursor for the biosynthesis of tetrapyrrole compounds, with wide applications in medicine, agriculture and other burgeoning fields. Because of its potential applications and disadvantages of chemical synthesis, alternative biotechnological methods have drawn increasing attention. In this review, the recent progress in biosynthetic pathways and regulatory mechanisms of 5-ALA synthesis in biological hosts are summarized. The research progress on 5-ALA biosynthesis via the C4/C5 pathway in microbial cells is emphasized, and the corresponding biotechnological design strategies are highlighted and discussed in detail. In addition, the detection methods and applications of 5-ALA are also reviewed. Finally, perspectives on potential strategies for improving the biosynthesis of 5-ALA and understanding the related mechanisms to further promote its industrial application are conceived and proposed.

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Section: Photosensitizers and Cosmeticsmentioning

confidence: 99%