Effects of 45-day -6° head-down bed rest on the time-based prospective memory

Chen, SiYi; Zhou, Renlai; Xiu, Lichao; Chen, Shanguang; Chen, Xiaoping; Tan, Chongqing

doi:10.1016/j.actaastro.2012.10.040

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…Similarly, Lipnicki et al (2009) studied the effects of 60-day HDBR and found declines in working memory performance. Another study also examined healthy young individuals regarding time-based prospective memory with an ongoing word recall task and identified impaired prospective memory during HDBR compared to baseline (Chen et al, 2013). Although the behavioral effects of HDBR on spatial working memory are mixed, it seems that long-duration HDBR largely does not affect working memory abilities, with only one study showing differences due to 7 days of HDBR.…”

Section: Spatial Working Memory Behavioral Resultsmentioning

confidence: 99%

“…Individuals in this cohort showed improvements in card rotation performance (i.e., a learning effect and no effect of the intervention) and no changes in cube rotation and working memory (Lee et al, 2019a). Although several recent studies have reported HDBR-and spaceflight-related changes in spatial working memory abilities (Leone et al, 1995;Lipnicki et al, 2009;Chen et al, 2013;Wang et al, 2017), there is still little understanding regarding how HDBR may affect the neural processing of spatial working memory. Further, no previous work has investigated neural spatial working memory changes with a combined HDBR and elevated CO 2 , which better mimics the elevated CO 2 onboard the ISS (Law et al, 2014).…”

Section: Introductionmentioning

confidence: 83%

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Neural Working Memory Changes During a Spaceflight Analog With Elevated Carbon Dioxide: A Pilot Study

Salazar

Hupfeld

Lee

et al. 2020

Front. Syst. Neurosci.

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Spaceflight missions to the International Space Station (ISS) expose astronauts to microgravity, radiation, isolation, and elevated carbon dioxide (CO 2), among other factors. Head down tilt bed rest (HDBR) is an Earth-based analog for spaceflight used to study body unloading, fluid shifts, and other factors unrelated to gravitational changes. While in space, astronauts need to use mental rotation strategies to facilitate their adaptation to the ISS environment. Therefore, spatial working memory is essential for crewmember performance. Although the effects of HDBR on spatial working memory have recently been studied, the results are still inconclusive. Here, we expand upon past work and examine the effects of HDBR with elevated CO 2 (HDBR + CO 2) on brain activation patterns during spatial working memory performance. In addition, we compare brain activation between 30 days of HDBR + CO 2 and 70 days of HDBR to test the isolated effect of CO 2. Eleven subjects (6 males, 5 females; mean age = 34 ± 8 years) underwent six functional magnetic resonance imaging (fMRI) sessions pre-, during, and post-HDBR + CO 2. During the HDBR + CO 2 intervention, we observed decreasing activation in the right middle frontal gyrus and left regions of the cerebellum, followed by post-intervention recovery. We detected several correlations between brain and behavioral slopes of change with the HDBR + CO 2 intervention. For example, greater increases in activation in frontal, temporal and parietal regions were associated with larger spatial working memory improvements. Comparing the HDBR + CO 2 group to data from our previous 70-day HDBR study, we found greater decreases in activation in the right hippocampus and left inferior temporal gyrus for the HDBR + CO 2 group over the course of the intervention. Together, these findings increase our understanding of the neural mechanisms of HDBR, elevated levels of CO 2 and spaceflight-related changes in spatial working memory performance.

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Section: Spatial Working Memory Behavioral Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 83%

Neural Working Memory Changes During a Spaceflight Analog With Elevated Carbon Dioxide: A Pilot Study

Salazar

Hupfeld

Lee

et al. 2020

Front. Syst. Neurosci.

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“…Further studies will have to be done to clarify whether such influence of microgravity on higher cognitive functions is transient or relevant. Useful information about how microgravity may impact on cognition may also stem from investigations of cognitive status in divers and pilots who may show similar pattern of performance (e.g., Steinberg and Doppelmayr, 2017;Causse et al, 2019). These works may add to the issue of compensatory mechanisms that individuals develop to cope with extreme environmental conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Prospective memory may be a crucial process especially during the operations of a space mission in which the astronauts must, for example, remember to press that button at that particular moment. As far as we know the only study on the effects of microgravity in a prospective memory task is the one by Chen et al (2013). In this experiment, participants were tested in HDBR condition that lasted 45 days.…”

Section: Prospective Memory With Earth-based Simulationsmentioning

confidence: 99%

The Effect of Microgravity-Like Conditions on High-Level Cognition: A Review

Mammarella

2020

Front. Astron. Space Sci.

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With an increasing interest in space traveling, the potential risks and benefits of microgravity on mental functioning is becoming a central research issue. Here we briefly reviewed a series of behavioral studies in order to identify what is known and not known about the effects of microgravity on higher cognitive functions. We first used a general approach to describe the interaction between microgravity and higher cognition. Subsequently, we analytically described a series of studies that focused on single high-level cognitive processes (e.g., mental imagery, working memory, etc.). Altogether, these findings point to a complex pattern of data mainly explained by the variety of methodological aspects (e.g., duration of microgravity-like conditions, low number of studies). Even so, the importance of higher-level cognitive functions for space performance remains fundamental and deserves further attention. These data are ultimately interesting in light of the potential long-term effects that microgravity may play on return to Earth.

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“…To date, researchers have mainly focused on the changes of physiological functions after bed rest, such as bone mineral and lean tissue loss (Antonutto & Di Prampero, ; Convertino, , ; Launius, ; Meck, Dreyer, & Warren, ; Stupakov, Kazeikin, & Morukov, ). Some researchers have also investigated the higher order cognitive functional changes during bed rest, such as memory and executive function (Chen et al, ; Eddy, Schiflett, Schlegel, & Shehab, ; Lipnicki, Gunga, Belavy, & Felsenberg, ; Manzey, Lorenz, Schiewe, Finell, & Thiele, ; Seaton, Slack, Sipes, & Bowie, ; Shehab, Schlegel, Schiflett, & Eddy, ; Zhao, Wang, Zhou, Wang, & Tan, ) as well as judgment and decision making (Jiang et al, ; Lipnicki, Gunga, Belavy, & Felsenberg, ; Rao et al, ). Thus far, however, compared with the physiological and cognitive functions, research concerning the effects of bed rest on cooperation and aggression is rare.…”

Section: Introductionmentioning

confidence: 99%

Effect of 45‐Day −6° Head‐Down Bed Rest on Cooperation and Aggression

Wang

Zhou

Rao

et al. 2017

Applied Cognitive Psychology

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High levels of cooperation and low aggression seem obviously vital to the successful implementation of space missions. To elucidate the effect of microgravity on these behaviors, we investigated whether cooperative and aggressive behaviors would be affected in 16 male volunteers during 45-day À6°head-down bed rest, which is a reliable simulation model for most physiological effects of spaceflight. We used an ultimatum game task to evaluate the cooperative behavior and a revised competitive reaction time test to evaluate the aggressive behavior simultaneously. We found that (1) the participants became less cooperative in the post-bed rest phase in comparison with the pre-bed rest phase and (2) the participants became more aggressive in the in-bed rest phase in comparison with the pre-bed rest phase. These findings provide evidence that head-down bed rest may affect both cooperative and aggressive behaviors in males, suggesting an important perspective for future studies in space psychology.

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Effects of 45-day -6° head-down bed rest on the time-based prospective memory

Cited by 11 publications

References 19 publications

Neural Working Memory Changes During a Spaceflight Analog With Elevated Carbon Dioxide: A Pilot Study

Neural Working Memory Changes During a Spaceflight Analog With Elevated Carbon Dioxide: A Pilot Study

The Effect of Microgravity-Like Conditions on High-Level Cognition: A Review

Effect of 45‐Day −6° Head‐Down Bed Rest on Cooperation and Aggression

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