Effects of 28 Days of Oral Dimethandrolone Undecanoate in Healthy Men: A Prototype Male Pill

Thirumalai, Arthi; Čeponis, Jonas; Amory, John K.; Swerdloff, Ronald S.; Surampudi, Vijaya; Liu, Peter Y; Bremner, William J.; Harvey, Eric; Blithe, Diana L.; Lee, Min S.; Hull, Laura; Wang, Christina; Page, Stephanie T.

doi:10.1210/jc.2018-01452

Cited by 44 publications

(42 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DMAU is a substance with androgenic and progestagenic effects. A study [12] on men taking this medicine for 28 days orally did not show any serious side effects, treatment was well tolerated. Doses> 200mg significantly inhibited serum testosterone, LH and FSH.…”

Section: Hormonal Male Contraceptivesmentioning

confidence: 87%

Methods of contraception for men

Łopuszyńska

Pawlicki

Piekarska

et al. 2020

J Educ Health Sport

View full text Add to dashboard Cite

Many pregnancies in the world are unintentional and some of them end in abortion, hence there is a great need and amount of research on contraceptives. There are many methods of pregnancy prevention for women. However, men also want to be responsible for their reproductive health. Currently, there are few methods of contraception for men (male condoms, vasectomy, withdrawal) and they have their drawbacks, so research on new contraceptives for men is ongoing. Hormonal methods under research include testosterone, nestorone, and DMAU. On the other hand, adjudin, WIN 18.446, BMS-189453 and RISUG are promising methods of non-hormonal male contraception. These substances can be a discovery and a breakthrough in male contraception, they will allow men to better control their fertility and reproductive health, and can also be a suitable solution for couples in which there are contraindications for women to use contraception.

show abstract

Section: Hormonal Male Contraceptivesmentioning

confidence: 87%

Methods of contraception for men

Łopuszyńska

Pawlicki

Piekarska

et al. 2020

J Educ Health Sport

View full text Add to dashboard Cite

show abstract

“…53 Similarly, early clinical studies in men have demonstrated short-term safety and tolerability with reversible suppression of gonadotropins. 54 Phase II testing of this compound is ongoing.…”

Section: Review Of Current and Future Methods Of Male Contraception Amentioning

confidence: 99%

“…Preclinical studies in rodents and rabbits have demonstrated reversible suppression of gonadotropins and sperm after the oral administration of DMAU . Similarly, early clinical studies in men have demonstrated short‐term safety and tolerability with reversible suppression of gonadotropins . Phase II testing of this compound is ongoing.…”

Section: Experimental Male Contraceptivesmentioning

confidence: 98%

Development of Novel Male Contraceptives

Amory

2019

Clinical Translational Sci

View full text Add to dashboard Cite

Unintended pregnancy is surprisingly common, accounting for 40–50% of pregnancies worldwide. Contraception is the most effective means of preventing unintended pregnancy. Seventy percent of all contraceptives are used by women; however, some women are unable to use contraceptives due to health conditions or side effects. Many men wish to take a more active role family planning, but currently have only two effective male contraceptive options, condoms and vasectomy. Therefore, work to develop novel male contraceptives analogous to popular female methods, such as daily pills or long‐acting shots and implants, is underway. This paper will briefly discuss the pros and cons of condoms and vasectomies, and then review the research into novel methods of male contraception.

show abstract

“…Novel androgens with progestational activity have been found to be safe and well tolerated in Phase I trials [62,63]. These compounds allow the development of compounds with activities on both the androgen and progesterone receptors as a single agent hormonal male contraceptive.…”

Section: Novel Androgensmentioning

confidence: 99%

“…Dimethandrolone undecanoate (7α, 11β-dimethyl-19-nortestosterone) and 11βmethyl-19-nortestosterone (11β-MNTDC), both derivatives of 19-nortestosterone with androgenic and progestational activity that are bioavailable and active after oral administration, have been studied in animals for their effects on spermatogenesis suppression and to examine their safety profile [65][66][67]. Phase I clinical studies of these oral androgens have been completed showing that serum gonadotropins and testosterone are rapidly and markedly decreased, while the androgen effects are maintained [62,63,68,69]. Adverse events seen in short-term studies with these oral androgens with progestational activity include dose-dependent weight gain, decrease in HDL cholesterol, and changes in mood.…”

Section: Novel Androgensmentioning

confidence: 99%

Continuing the search for a hormonal male contraceptive

Yuen

Nguyen

Swerdloff

et al. 2020

Best Practice & Research Clinical Obstetrics & Gynaecol

Self Cite

View full text Add to dashboard Cite

This chapter discusses the mechanisms of action of hormonal male contraception, which suppresses the hypothalamic-pituitary-testis axis. When the intratesticular concentration of testosterone is subsequently suppressed to adequately low concentrations, spermatogenesis is arrested. Androgens are a necessary hormonal male contraceptive component because they not only suppress the hypothalamic-pituitary-testis axis, but also provide the male hormone necessary to maintain peripheral androgen functions. Past studies using testosterone alone and testosterone combined with progestins demonstrated contraceptive efficacy in the female partner at rates similar to combined hormonal female methods. Newer hormonal male contraceptive formulations and the alternative routes of administration are discussed, along with potential barriers, challenges, and opportunities for hormonal male contraceptive development. Novel methods that are safe, effective, reversible, user-friendly, and coitus-independent are intrinsic to equitably meet the various needs and limitations of an increasingly diverse population.

show abstract

Effects of 28 Days of Oral Dimethandrolone Undecanoate in Healthy Men: A Prototype Male Pill

Cited by 44 publications

References 39 publications

Methods of contraception for men

Methods of contraception for men

Development of Novel Male Contraceptives

Continuing the search for a hormonal male contraceptive

Contact Info

Product

Resources

About