Effects of 250 and 500 Hz Tone Exposure on the Inner Ear of Guinea Pigs as Determined by Electrophysiological Techniques

Fujita, Taketoshi; Sugisawa, Takahisa; Matsui, Toshitaka; Takahashi, Mitsuaki; Inada, Naofumi; Ishida, Akira; Yamamura, Kohtaroh

doi:10.1159/000276209

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…In our previous reports [9,10] and in an unpublished paper, as well as in the present paper, we have also investi gated the effect on the inner ear of moderate SPL and long-time exposure to low-frequency ultrasound using the elcctrophysiological method.…”

Section: Discussionmentioning

confidence: 71%

Effects of High-Frequency Sound on Electrochemical Potential Using the Single-Barrel Method in Guinea Pigs

Matsui¹,

Sugisawa²,

Ishida³

et al. 1993

ORL

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There are only a few studies investigating the effects of ultrasound on hearing. This paper reports on an experimental investigation on the effect of the longtime exposure to a moderate sound pressure level, high-frequency sound of 16 kHz on the guinea pig inner ear using electrophysiological methods. A decrease of the absolute value of negative potential was observed in the endo-cochlear potential (EP). The effects of high-frequency sound on EP and electrochemical potential could be explained by a change in the K⁺ permeability of hair cells.

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Section: Discussionmentioning

confidence: 71%

Effects of High-Frequency Sound on Electrochemical Potential Using the Single-Barrel Method in Guinea Pigs

Matsui¹,

Sugisawa²,

Ishida³

et al. 1993

ORL

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“…In another report [3], we investigated whether or not 250-and 500-Hz tone exposure affected the high-fre quency hearing. It was observed that exposure to 500 Hz had significant effects on the high-frequency function of the inner ear using three electrophysiological methods.…”

Section: Discussionmentioning

confidence: 99%

“…However there are only a few reports about the effect of low-frequency and mid-frequency (250-500 Hz) tone to high-frequency function of inner ear using electrophysiological method. By examining cochlear microphonics (CM) and action potentials (AP) in the cochlea of guinea pigs, authors reported that contin uous-tone exposure of 1-kHz pure tone [2] at 100 dB and pure tone of 500 Hz at 115 and 120 dB [3] induced changes in high-frequency hearing. Moreover, a change of endocochlear potential (EP) was observed.…”

Section: Introductionmentioning

confidence: 99%

Study of the Effect of 350-Hz Tone Exposure on Electrophysiological Function of the Inner Ear of Guinea Pigs

Yamamura

Sugisawa²,

Inada³

et al. 1992

ORL

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The effects of noise exposure were studied in fifty-nine 4- to 5-week-old albino Hartley guinea pigs with normal hearing (body weight 250-300 g). The follow-ing experiments and results were carried out: exposure to 350 Hz pure tones at 115 dB for 40 h and exposure to 350 Hz tones at 120 dB for 64 h. In order to investigate the effects of low-frequency tone exposures on the hearing of the guinea pigs, cochlear microphonics (CM), whole nerve action Potentials (AP) and endocochlear potentials (EP) were measured. With a high-sound pressure, a decrease was observed in the CM maximum Output voltage in the test fre-quencies of 2,4 and 6 kHz while the CM threshold (pseudothreshold) of 6 kHz was elevated. Output voltage of the Ni potential of the AP using a 7-kHz tone burst decreased while the threshold of the Ni potential was elevated. An exten-sion of latency and a decrease in the absolute value of the negative potential in EP were also observed.

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“…In these figures, the abscissa is the sound pressure (dB) of the stimuli and the ordinate is the logarithm of the CM (peak-to-peak) output voltage. Analyzing these data 5 tween output voltage of control animals and that of animals exposed to 100 dB sound at 600 Hz (Exp. 6).…”

Section: Chemical Potential Of K + Ionmentioning

confidence: 99%

“…In particular, 6 kHz tone exposures had a strong effect on the endocochlear potential (EP) [4,14]. However, exposure to low frequency tones of 250-500 Hz at high sound pressure levels also induced decreases in CM, action potential (AP) and EP in guinea pigs [5,20].…”

Section: Introductionmentioning

confidence: 99%

A comparative study on the effect of pure-tone exposure of the guinea pig cochlea

Hotta

Sugisawa

Rob

et al. 1996

Eur Arch Otorhinolaryngol

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Electrophysiological methods were applied to 160 healthy adult male guinea pigs in order to investigate the effects of pure-tone exposure for 24 h on the inner ear. A reduction in cochlear microphonics (CM), action potential (AP) and endocochlear potential was observed following exposure to 110 dB at 100 Hz, 100 dB at 200 and 600 Hz and 95 dB at 2 kHz. The observed K+ endolymphatic concentration during 40 min anoxia remained unchanged. In contrast K+ decreased in control animals and following exposure to pure tones varying from 110 dB at 60 Hz to 85 dB at 2 kHz. These findings indicate that high frequency tones have a greater effect on inner ear functions than those of lower frequency, decreasing the maximum output voltage of CM and AP but not changing K+ endolymphatic concentration.

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Effects of 250 and 500 Hz Tone Exposure on the Inner Ear of Guinea Pigs as Determined by Electrophysiological Techniques

Cited by 6 publications

References 14 publications

Effects of High-Frequency Sound on Electrochemical Potential Using the Single-Barrel Method in Guinea Pigs

Effects of High-Frequency Sound on Electrochemical Potential Using the Single-Barrel Method in Guinea Pigs

Study of the Effect of 350-Hz Tone Exposure on Electrophysiological Function of the Inner Ear of Guinea Pigs

A comparative study on the effect of pure-tone exposure of the guinea pig cochlea

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