Effects of 2-iodohexadecanal in the physiology of thyroid cells

Rossich, Luciano; Thomasz, Lisa; Nicola, Juan Pablo; Nazar, Magalí; Salvarredi, Leonardo; Pisarev, Mario A.; Masini-Repiso, Ana M.; Christophe-Hobertus, Christiane; Christophe, Daniel; Juvenal, Guillermo

doi:10.1016/j.mce.2016.08.036

Cited by 19 publications

(8 citation statements)

References 64 publications

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“…Therefore, the inhibitory effects of IE on thyroid gene expression could be mediated by iodide per se . However, the impairment of TSH signaling pathway by reduced TSHR expression or by IE-induced iodolipids production cannot be excluded ( 44 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

Iodine excess exposure during pregnancy and lactation impairs maternal thyroid function in rats

Serrano‐Nascimento

Salgueiro

Vitzel

et al. 2017

Endocrine Connections

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Adequate maternal iodine consumption during pregnancy and lactation guarantees normal thyroid hormones (TH) production, which is crucial to the development of the fetus. Indeed, iodine deficiency is clearly related to maternal hypothyroidism and deleterious effects in the fetal development. Conversely, the effects of iodine excess (IE) consumption on maternal thyroid function are still controversial. Therefore, this study aimed to investigate the impact of IE exposure during pregnancy and lactation periods on maternal hypothalamus–pituitary–thyroid axis. IE-exposed dams presented reduced serum TH concentration and increased serum thyrotropin (TSH) levels. Moreover, maternal IE exposure increased the hypothalamic expression of Trh and the pituitary expression of Trhr, Dio2, Tsha and Tshb mRNA, while reduced the Gh mRNA content. Additionally, IE-exposed dams presented thyroid morphological alterations, increased thyroid oxidative stress and decreased expression of thyroid genes/proteins involved in TH synthesis, secretion and metabolism. Furthermore, Dio1 mRNA expression and D1 activity were reduced in the liver and the kidney of IE-treated animals. Finally, the mRNA expression of Slc5a5 and Slc26a4 were reduced in the mammary gland of IE-exposed rats. The latter results are in accordance with the reduction of prolactin expression and serum levels in IE-treated dams. In summary, our study indicates that the exposure to IE during pregnancy and lactation induces primary hypothyroidism in rat dams and impairs iodide transfer to the milk.

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Section: Discussionmentioning

confidence: 99%

Iodine excess exposure during pregnancy and lactation impairs maternal thyroid function in rats

Serrano‐Nascimento

Salgueiro

Vitzel

et al. 2017

Endocrine Connections

View full text Add to dashboard Cite

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“…In our study we found better short time result in the group with preoperative preparation. The explanation for this might be the diminished blood supply after preoperative preparation [13]. However, we found no patients with permanent complications in the two groups.…”

Section: Discussionmentioning

confidence: 52%

“…These facts necessitate the need for a preoperative preparation to avoid intraoperative or postoperative thyroid storms and to decrease the vascularity of the gland [12]. Lugol solution (Inorganic iodide) is known to decreases the synthesis of thyroid hormone and their release from the thyroid in the short term (Wolff-Chaikoff effect) [13]. However one must have in mind the major flaw of this preoperative preparation -the Wolff-Chaikoff effect lasts 10-14 days and the escape phenomenon is possible [14].…”

Section: Discussionmentioning

confidence: 99%

Do we really Need Lugol Solution in the Era of Energy Devices for the Preoperative Management of Patients with Graves’ Disease?

Vidinov

Stoinov

2019

J Clin Exp Invest

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Introduction: Inorganic iodide (Lugol solution) has been used for the preoperative management of patients with Graves' disease for many years. However, some new instruments have come into the surgeons reach that can accomplish bloodless operative field without the need of preoperative treatment. The purpose of this prospective study was to evaluate the efficacy and safety in the application of two types of energy devices -SonoSurg® and Thunderbeat® in patients with and without preoperative preparation with Lugol solution. Material and Methods:The study included 100 patients with Greaves' disease operated between January 2017 and December 2017. Patients were divided into four groups -50 patients operated using SonoSurg® -25 patients with preoperative preparation with Lugol solution and 25 without preoperative PI preparation, and 50 patients operated using Thunderbeat® -25 patients with and 25 without preoperative Lugol preparation. We evaluated and compared the outcome between the four groups. Results:The four groups had a similar distribution in the demographic features such as gender, age, and functional activity. When comparing the results, we found very similar results in the groups with preoperative preparation with PI solution. In contrasts we found significant differences in the duration of surgery, intraoperative and postoperative complications between the groups without preoperative PI preparation. Hospital stay of patients in four groups was similar -an average of 2 days stay into the clinic. Conclusion:Our results showed that Lugol solution preparation has its place in the era of energy devices. Thunderbeat® can accomplish reliable hemostasis without preoperative Lugol preparation however we can achieve the same result with SonoSurg® and preoperative preparation at a much lower cost.

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“…Notably, in response to iodide overload, Nrf2 KO mice showed even higher levels of iodinated Tg [2], suggesting that Nrf2 has a role in thyroid autoregulation. Although the precise mechanisms underlying this effect have not yet been elucidated, we found that treatment of thyroid follicular cell lines with 2-iodohexadecanal, an iodolipid considered to be one of the main mediators of thyroid autoregulation [28], activated Nrf2, similar to iodide treatment [2]. Recently, we analyzed the transcriptomic response of the mouse thyroid to iodide overload using next-generation RNA sequencing in WT and Nrf2 KO mice.…”

Section: Thyroid Physiologymentioning

confidence: 99%

The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update

et al. 2020

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The thyroid gland has a special relationship with oxidative stress. On the one hand, like all other tissues, it must defend itself against reactive oxygen species (ROS). On the other hand, unlike most other tissues, it must also produce reactive oxygen species in order to synthesize its hormones that contribute to the homeostasis of other tissues. The thyroid must therefore also rely on antioxidant defense systems to maintain its own homeostasis in the face of continuous self-exposure to ROS. One of the main endogenous antioxidant systems is the pathway centered on the transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) and its cytoplasmic inhibitor Kelch-like ECH-associated protein 1 (Keap1). Over the last few years, multiple links have emerged between the Keap1/Nrf2 pathway and thyroid physiology, as well as various thyroid pathologies, including autoimmunity, goiter, hypothyroidism, hyperthyroidism, and cancer. In the present mini-review, we summarize recent studies shedding new light into the roles of Keap1/Nrf2 signaling in the thyroid.

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Effects of 2-iodohexadecanal in the physiology of thyroid cells

Cited by 19 publications

References 64 publications

Iodine excess exposure during pregnancy and lactation impairs maternal thyroid function in rats

Iodine excess exposure during pregnancy and lactation impairs maternal thyroid function in rats

Do we really Need Lugol Solution in the Era of Energy Devices for the Preoperative Management of Patients with Graves’ Disease?

The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update

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