2007
DOI: 10.1016/j.tox.2007.07.009
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Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice

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Cited by 61 publications
(42 citation statements)
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“…The analysis of endogenous regulators of red-ox homeostasis revealed that reduction of GPx activity was the fi rst event induced by prolonged exposure to low MeHg concentration before changes in glutathione (GSH), catalase and glutathione reductase (GR) could be observed (Farina et al 2009 ) . In agreement, GPx inhibition and lipid peroxidation were found to occur earlier than GSH and GR changes in animals prenatally exposed to MeHg (Carvalho et al 2007 ;Stringari et al 2008 ) . Probucol increased GPx activity by itself and inhibited MeHg-induced lipid peroxidation, whereas the antioxidants ascorbic acid and trolox did not (Fig.…”
Section: Effect Of Methylmercury On Cellular Red-ox Homeostasissupporting
confidence: 71%
“…The analysis of endogenous regulators of red-ox homeostasis revealed that reduction of GPx activity was the fi rst event induced by prolonged exposure to low MeHg concentration before changes in glutathione (GSH), catalase and glutathione reductase (GR) could be observed (Farina et al 2009 ) . In agreement, GPx inhibition and lipid peroxidation were found to occur earlier than GSH and GR changes in animals prenatally exposed to MeHg (Carvalho et al 2007 ;Stringari et al 2008 ) . Probucol increased GPx activity by itself and inhibited MeHg-induced lipid peroxidation, whereas the antioxidants ascorbic acid and trolox did not (Fig.…”
Section: Effect Of Methylmercury On Cellular Red-ox Homeostasissupporting
confidence: 71%
“…Previous studies also showed that exposures to MeHg produce behavioral deficits related to locomotor activity and motor performance in mice (Carvalho et al, 2007;Franco et al, 2009;Stringari et al, 2006Stringari et al, , 2008 and rats Fujimura et al, 2012;Sakamoto et al, 2002). Notably, MeHginduced changes on locomotor activity and motor performance were associated with prooxidative events in the cerebellum.…”
Section: Discussionmentioning
confidence: 85%
“…(Dietrich et al, 2005;Ni et al, 2012;Farina et al, 2013). It is of interest that MeHginduced cerebellar toxicity was reported to be a result of pro-oxidative effects toward the antioxidant glutathione (GSH)-dependent system (Carvalho et al, 2007;Farina et al, 2011aFarina et al, , 2011b. Data demonstrated a significant main effect of MeHg toward cerebellar GPx activity ( Figure 3A), although L-Met exerted no significant effect and no marked MeHg by LMet interaction was detected.…”
Section: Gpx Activitymentioning
confidence: 97%
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“…In addition to this SOD-related research, it has been found in a number of studies that decreased GPx activity in the brains was caused by the mice being given MeHg at a concentration of 40 mg/L in drinking water for several weeks (Carvalho et al, 2007;Farina et al, 2003b;Franco et al, 2009;Glaser et al, 2010). Stringari et al (2008) reported that exposing pregnant mice to MeHg at concentrations of 1, 3, and 10 mg/L in drinking water induced a dose-dependent and long-lasting inhibitory effect on the occurrence of cerebral antioxidant enzymes, such as GPx, which is a developmental phenomenon, in their pups.…”
Section: Oxidative Stress and S-mercurationmentioning
confidence: 99%