2003
DOI: 10.1007/s00204-003-0445-z
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Effects of 2,3,7,8-TCDD and PCB 126 on human thymic epithelial cells in vitro

Abstract: 2,3,7,8-Tetrachloro-dibenzo- p-dioxin (TCDD) is a ubiquitously distributed xenobiotic. The adverse effects of TCDD on the mammalian immune system have been studied for decades, but it is still unclear whether TCDD has direct effects on T-lymphocytes or whether it acts via the thymic microenvironment. We have studied the effects of TCDD on primary cultures of human thymic epithelial cells (TEC) focusing on differentiation markers, integrins and adhesion molecules involved in cell-cell and in cell-matrix interac… Show more

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Cited by 11 publications
(8 citation statements)
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“…1). In the monocytic leukemia THP-1 cell line, mRNA levels of β7 and α5 integrins are increased following AhR activation, whereas expression of α6 is decreased in human thymic epithelial cells (23). The increase in β7 integrin is also observed in primary human macrophages and developing T-lymphocytes (24,25).…”
Section: The Ahr Pathway In the Regulation Of The Extracellular Mamentioning
confidence: 99%
See 1 more Smart Citation
“…1). In the monocytic leukemia THP-1 cell line, mRNA levels of β7 and α5 integrins are increased following AhR activation, whereas expression of α6 is decreased in human thymic epithelial cells (23). The increase in β7 integrin is also observed in primary human macrophages and developing T-lymphocytes (24,25).…”
Section: The Ahr Pathway In the Regulation Of The Extracellular Mamentioning
confidence: 99%
“…(1) AhR pathway alters the expression of ECM proteins, including types I and IV collagen and fibronectin in fetal heart and marmoset myocardium and thymocytes (1720). (2) Expression of several integrin subtypes, including the β7 subtype is altered following AhR signaling in cytotoxic T-cells (22), thymic epithelial cells (23), macrophages (24), T-lymphocytes (25) and human amniotic epithelial cells (26). (3) Focal adhesion kinase (FAK) phosphorylation in HUVECs (29).…”
Section: Figuresmentioning
confidence: 99%
“…The TGF-β pathway, in turn, is controlled by the activity of αv integrins in glioma cells (11). AhR has been described as a regulator of the composition of integrins at the cell surface (13,(20)(21)(22)(23), but inhibitory effects of AhR on FAK phosphorylation, a central mediator of integrin signaling, have also been observed (14,24). These findings provided the rationale for the present study, which aimed at elucidating a possible link between the AhR and integrin signaling pathways in modulating the activity of the TGF-β pathway in glioblastoma.…”
Section: Discussionmentioning
confidence: 99%
“…TSC function within the realm of toxicology has intensely focused on the role of the aryl hydrocarbon receptor (AhR) and toxicity due to AhR ligation. Early evidence and follow-up studies suggest that AhR agonists, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), affect thymic epithelial cells but not thymocytes nor thymic dendritic cells (DCs) to cause thymic involution (Camacho et al, 2005;De Heer et al, 1994;De Waal et al, 1992;Greenlee et al, 1985;Kremer et al, 1994;Laiosa et al, 2003;Riecke et al, 2003). Since then, reports found precursor (Fine et al, 1990) or hematopoietic cells (including thymocytes) (Kamath et al, 1997;Kurl et al, 1993;Laiosa et al, 2010;McConkey et al, 1988;Rhile et al, 1996;Staples et al, 1998) to be the direct targets for AhR-mediated thymic involution.…”
Section: Stromal Cells In Thymus Bone Marrow and Lymph Nodesmentioning
confidence: 99%