Effects of 17α-ethynylestradiol on sexual differentiation and development of the African clawed frog (Xenopus laevis)

Tompsett, Amber R.; Wiseman, Steve; Higley, Eric; Pryce, Sara; Chang, Hak; Giesy, John P.; Hecker, Markus

doi:10.1016/j.cbpc.2012.06.002

Cited by 21 publications

(42 citation statements)

References 30 publications

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“…In present study, 1 nM EE2 prolonged the time to reach stage 58 of X. laevis (Table 3). Similar to our results, in Tompsett's et al (2012) study, exposure to EE2 also resulted in a significant delay in the time for X. laevis metamorphosis.…”

Section: Discussionsupporting

confidence: 81%

Determining the optimal developmental stages of Xenopus laevis for initiating exposures to chemicals for sensitively detecting their feminizing effects on gonadal differentiation

Chen

Qin

2016

Aquatic Toxicology

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Section: Discussionsupporting

confidence: 81%

Determining the optimal developmental stages of Xenopus laevis for initiating exposures to chemicals for sensitively detecting their feminizing effects on gonadal differentiation

Chen

Qin

2016

Aquatic Toxicology

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“…PPCPs are produced by pharmaceutical and manufacturing industries (Pal et al ) and can enter the environment via multiple pathways, including wastewater treatment systems (e.g., septic tanks and sewer systems) or industrial agricultural practices (Heberer ). Because many EOCs are designed to be physiologically active at low concentrations, special concern has been placed on their ecotoxicological impacts throughout food webs (e.g., Lagesson et al ; Meador et al ), including algae (e.g., Lai et al ; Rosi‐Marshall et al ), aquatic insects (e.g., Dietrich et al ; Fong and Ford ; Lee et al ), fish (e.g., Jobling et al ; Olivares‐Rubio et al ), and amphibians (e.g., Tompsett et al ). Long‐term exposures to small concentrations (e.g., ng/L) can have adverse effects on growth and development of organisms, and ultimately on ecosystem function (e.g., Hoppe et al ; Rosi‐Marshall and Royer ; Fong and Ford ).…”

Section: Metals and Emerging Contaminantsmentioning

confidence: 99%

“…In contrast, increased thermal stratification associated with warming in Lake Tanganyika has caused decreases in productivity and declines in biomass throughout the food web (O'Reilly et al 2003;Verburg et al 2003;Cohen et al 2016), and similar trends are likely in other permanently stratified lakes such as Lake Malawi. In Lake Biwa, warmer winters have altered dominant winter phytoplankton and subsequently the ability of certain zooplankton to overwinter (Tsugeki et al 2009). Based on studies in geologically younger lakes, warming is likely to have cascading effects in food webs (Adrian et al 2009), including but not restricted to altering plankton and fish phenology (Weyhenmeyer et al 1999;Adrian et al 2006;Thackeray et al 2010), organism body size (Moore et al 1996), harmful algal blooms (Paerl and Huisman 2009), and ecosystem-level greenhouse gas emissions (Ducharme-Riel et al 2015).…”

Section: Modern Climate Change Effects On Ancient Lakesmentioning

confidence: 99%

Recent ecological change in ancient lakes

Hampton

McGowan

Ozersky

et al. 2018

Limnology & Oceanography

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Ancient lakes are among the best archivists of past environmental change, having experienced more than one full glacial cycle, a wide range of climatic conditions, tectonic events, and long association with human settlements. These lakes not only record long histories of environmental variation and human activity in their sediments, but also harbor very high levels of biodiversity and endemism. Yet, ancient lakes are faced with a familiar suite of anthropogenic threats, which may degrade the unusual properties that make them especially valuable to science and society. In all ancient lakes for which data exist, significant warming of surface waters has occurred, with a broad range of consequences. Eutrophication threatens both native species assemblages and regional economies reliant on clean surface water, fisheries, and tourism. Where sewage contributes nutrients and heavy metals, one can anticipate the occurrence of less understood emerging contaminants, such as pharmaceuticals, personal care products, and microplastics that negatively affect lake biota and water quality. Human populations continue to increase in most of the ancient lakes’ watersheds, which will exacerbate these concerns. Further, human alterations of hydrology, including those produced through climate change, have altered lake levels. Co‐occurring with these impacts have been intentional and unintentional species introductions, altering biodiversity. Given that the distinctive character of each ancient lake is strongly linked to age, there may be few options to remediate losses of species or other ecosystem damage associated with modern ecological change, heightening the imperative for understanding these systems.

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“…For example, mammalian hormones, commonly used in birth control and hormone therapy, have been linked to endocrine disruption in reptiles, birds, and some arthropods (Gonzalez et al, 2001;Hoffmann and Kloas, 2012;Jindra et al, 2013;Tompsett et al, 2013Tompsett et al, , 2012Watts et al, 2003Watts et al, , 2001. They also have been shown to alter primary and secondary sexual characteristics such as gonads and mating and courtships behaviors (Gonzalez et al, 2001;Hoffmann and Kloas, 2012;Tompsett et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

Pharmaceuticals and personal care products alter the holobiome and development of a medically important mosquito

Pennington

Rivas

Prager

et al. 2015

Environmental Pollution

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The increasing demand for fresh water has forced many countries to use reclaimed wastewater for agricultural purposes. This water contains pharmaceuticals and personal care products (PPCPs) that remain biologically active following passage through wastewater treatment plants. Run-off from farms and contaminated water from treatment facilities exposes aquatic ecosystems to PPCPs. This study examined the effects of PPCPs on a lower trophic organism. Culex quinquefasciatus larvae were reared in water contaminated with environmentally relevant concentrations of common PPCPs. Acetaminophen alone and a mixture of contaminants were found to increase developmental time of larvae. Susceptibility to Bti increased in larvae exposed to antibiotics, acetaminophen, or a mixture of PPCPs. Antibiotics, hormones, and the mixture altered the mosquito bacterial microbiome. Overall, the results indicate that at environmentally relevant concentrations, PPCPs in reclaimed water can have biologically important effects on an ecologically and medically important lower trophic level insect.

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Effects of 17α-ethynylestradiol on sexual differentiation and development of the African clawed frog (Xenopus laevis)

Cited by 21 publications

References 30 publications

Determining the optimal developmental stages of Xenopus laevis for initiating exposures to chemicals for sensitively detecting their feminizing effects on gonadal differentiation

Determining the optimal developmental stages of Xenopus laevis for initiating exposures to chemicals for sensitively detecting their feminizing effects on gonadal differentiation

Recent ecological change in ancient lakes

Pharmaceuticals and personal care products alter the holobiome and development of a medically important mosquito

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