Effects of 12-week combined exercise therapy on oxidative stress in female fibromyalgia patients

Abstract

The aims of this study were to investigate the effect of exercise therapy on the oxidative stress in fibromyalgia patients and relationship between oxidative stress and fibromyalgia symptoms. Thirty women diagnosed with fibromyalgia according to the American College of Rheumatology preliminary criteria, and 23 healthy women whose age- and weight-matched women were enrolled the study. Pain intensity with visual analog scale (VAS), the number of tender points, the fibromyalgia impact questionnaire (FIQ), the Beck depression inventory (BDI) were evaluated. The oxidative stress parameters thiobarbituric acid reactive substances, protein carbonyls, and nitric oxide, and antioxidant parameters thiols and catalase were investigated in patients and control group. After, combined aerobic and strengthen exercise regimen was given to fibromyalgia group. Exercise therapy consisted of a warming period of 10 min, aerobic exercises period of 20 min, muscle strengthening exercises for 20 min, and 10 min cooling down period. Therapy was lasting 1 h three times per week over a 12-week period. All parameters were reevaluated after the treatment in the patient group. The oxidative stress parameters levels were significantly higher, and antioxidant parameters were significantly lower in patients with fibromyalgia than in the controls. VAS, FIQ, and BDI scores decreased significantly with exercise therapy. The exercise improved all parameters of oxidative stress and antioxidant parameters. Also, all clinical parameters were improved with exercise. We should focus on oxidative stress in the treatment for fibromyalgia with the main objective of reducing oxidative load.

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia

“…In a study by Tetik et al, 21 plasma thiol levels were shown to be decreased in rheumatoid arthritis and primary osteoarthritis patients. Similarly, Altindag et al 32 and Sarifakioglu et al 34 found that plasma thiol levels were significantly lower in FMS patients compared with control subjects. However, due to the current measurement failure, they were only able to measure the thiol levels of homeostasis, while they were unable to measure disulphide and total thiol levels.…”

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

“…Only one study included an exercise-only group in their study design, which seemed to have no effects on levels of oxidative stress, in contrast to prior reports on exercise-only interventions [12,13,14,15]. Combined diet- and exercise-induced weight loss interventions may achieve an additional benefit with respect to oxidative stress, DNA repair, and telomere length.…”

“…Intensive physical exercise may adversely influence the balance between oxidative and anti-oxidative factors and, thus, cause increased levels of oxidative stress [11]. Nevertheless, several exercise-only interventions have reported a reduction of biomarkers of oxidative stress [12,13,14,15]. Thus, the evidence is not entirely consistent and suggests that there may be differences attributable to varying types of exercise interventions (e.g., duration, intensity, aerobic, anaerobic).…”

The Effects of Copenhagen Football Test on Glutathione Reductase and Catalase Activity in Female Football Players

“…In most studies, an increase in the activity of the enzyme glutathione reductase was observed after exercise (22). However, some studies have observed an increase in the catalase activity after exercise (23,24) some observed no change (25,26), and some found even lower (27) activity that could have implications on the role of the increase in glutathione as coenzyme glutathione oxidase. During the action of glutathione reductase, glutathione is regenerated and converted to oxidized glutathione that turns NADPH to glutathione again by glutathione reductase (2).…”