Effects of 12 Months Treatment with <scp>l</scp>-Selenomethionine on Serum Anti-TPO Levels in Patients with Hashimoto's Thyroiditis

Mazokopakis, Elias E.; Papadakis, John A.; Papadomanolaki, Maria G.; Batistakis, Antony G; Giannakopoulos, Triantafillos G.; Protopapadakis, Eftychios; Ganotakis, Emmanuel S.

doi:10.1089/thy.2007.0040

Cited by 132 publications

(90 citation statements)

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“…In addition, based on the data from two studies, the beneficial effect of selenium supplementation was confirmed regarding the mood of the patients [126]. Brief characteristics of the most important prospective clinical studies [98,122,[127][128][129][130][131][132][133][134][135][136][137][138][139][140][141][142][143][144] concerning the efficacy of supplementation with selenium in benign thyroid diseases, in particular autoimmune diseases, are presented in Table II.…”

Section: ) Short Characteristics Of the Most Important Clinical Trimentioning

confidence: 99%

The role of selenium in thyroid gland pathophysiology

Stuss¹,

Michalska-Kasiczak

Sewerynek³

2017

Endokrynologia Polska

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It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires also a number of elements, including selenium, iron, zinc, copper, and calcium. In many cases, only an adequate supply of one of these microelements (e.g. iodine) may reveal symptoms resulting from deficits of other microelements (e.g. iron or selenium). Selenium is accounted to the trace elements of key importance for homeostasis of the human system, in particular, for the proper functioning of the immune system and the TG. Results of epidemiological studies have demonstrated that selenium deficit may affect as many as one billion people in many countries all over the world. A proper sequence of particular supplementations is also worth emphasising for the significant correlations among the supplemented microelements. For example, it has been demonstrated that an excessive supplementation of selenium may enhance the effects of iodine deficit in endemic regions, while proper supplementation of selenium in studied animals may alleviate the consequences of iodine excess, preventing destructive-inflammatory lesions in the TG. This paper is a summary of the current knowledge on the role of selenium in the functionality of the TG.

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Section: ) Short Characteristics Of the Most Important Clinical Trimentioning

confidence: 99%

The role of selenium in thyroid gland pathophysiology

Stuss¹,

Michalska-Kasiczak

Sewerynek³

2017

Endokrynologia Polska

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“…1,2 By strict criteria, it is a histologic diagnosis that was first described by Hakaru Hashimoto, a Japanese surgeon working in Berlin, Germany. 3 The cause of HT is thought to be a combination of genetic susceptibility and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma. A retrospective study

Mazokopakis¹,

Tzortzinis²,

Dalieraki-Ott³

et al. 2010

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OBJECTIVE: The association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains controversial in medical bibliography. The main objective of our study was to determine the prevalence of PTC and HT coexistence in histopathologic material of thyroidectomized patients. DESIGN: In a retrospective study, the clinicohistopathologic data of 140 patients (19 males/121 females), who underwent a total or near total thyroidectomy for any thyroid pathology from January 2005 to December 2009 at the Naval Hospital of Crete, were analysed. The mean age of the patients was 52 years (range 16-74). rESULTS: HT was detected in 42 (30%) and PTC in 32 (22.9%) specimens. Coexistence of HT with PTC was present in 12 (8.6%) specimens. Among 32 specimens with PTC, the prevalence of HT was 37.5%. Among 42 specimens with HT, the prevalence of PTC was 28.6%. There was no statistically significant difference between the presence of PTC and HT in histopathologic material. CONCLUSIONS: The prevalence of PTC and HT coexistence in histopathologic material of 140 thyroidectomized patients was 8.6%, whereas the difference between PTC and HT was not statistically significant.

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“…This result was in accordance with those observed in clinical trails. Supplementation of 200 μg Se per day suppressed anti-thyroperoxidase antibody (TPOAb) levels in patients with AIT in low dietary Se intake [7], in mild selenium deficiency [3], and in a borderline Se sufficient region [4]. There was an additional decrease of TPOAb titers with the extension of Se supplementation lasted for more 3 or 6 months [3-5, 7, 14].…”

Section: Discussionmentioning

confidence: 99%