Effects Of 10 Days Of Modest Intermittent Hypoxia On Circulating Measures Of Inflammation In Healthy Humans

Querido, Jordan S.; Sheel, William; Cheema, Rupi; vanEeden, Stephan F.; Mulgrew, Alan; Ayas, Najib

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2473

Cited by 6 publications

(5 citation statements)

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“…Thus, the discussion is limited to TNF-α. The maintenance of serum TNF-α concentration after IH within the placebo condition is in contrast with results reporting an increase in TNF-α in rats after only 3 h of IH exposure, but is similar to a previous human study using a less severe IH exposure [48]. This maintenance of serum TNF-α concentrations following IH exposure during the placebo condition does not necessarily indicate that inflammation is not involved in augmenting the AHVR, as systemic TNF-α may not reflect carotid body concentrations [25] nor central inflammation.…”

Section: Ahvr and Ahcvrsupporting

confidence: 84%

Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation

et al. 2015

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Ventilatory instability, reflected by enhanced acute hypoxic (AHVR) and hypercapnic (AHCVR) ventilatory responses is a fundamental component of obstructive sleep apnoea (OSA) pathogenesis. Intermittent hypoxia-induced inflammation is postulated to promote AHVR enhancement in OSA, although the role of inflammation in intermittent hypoxia-induced respiratory changes in humans has not been examined. Thus, this study assessed the role of inflammation in intermittent hypoxiainduced respiratory plasticity in healthy humans.In a double-blind, placebo-controlled, randomised crossover study design, 12 males were exposed to 6 h of intermittent hypoxia on three occasions. Prior to intermittent hypoxia exposures, participants ingested (for 4 days) either placebo or the nonsteroidal anti-inflammatory drugs indomethacin (nonselective cyclooxygenase (COX) inhibitor) and celecoxib (selective COX-2 inhibitor). Pre-and post-intermittent hypoxia resting ventilation, AHVR, AHCVR and serum concentration of the pro-inflammatory cytokine tumour necrosis factor (TNF)-α were assessed.Pre-intermittent hypoxia resting ventilation, AHVR, AHCVR and TNF-α concentrations were similar across all three conditions ( p⩾0.093). Intermittent hypoxia increased resting ventilation and the AHVR similarly across all conditions ( p=0.827), while the AHCVR was increased ( p=0.003) and TNF-α was decreased ( p=0.006) with only selective COX-2 inhibition.These findings indicate that inflammation does not contribute to human intermittent hypoxia-induced respiratory plasticity. Moreover, selective COX-2 inhibition augmented the AHCVR following intermittent hypoxia exposure, suggesting that selective COX-2 inhibition could exacerbate OSA severity by increasing ventilatory instability. @ERSpublications Nonsteroidal anti-inflammatory drugs do not prevent intermittent hypoxia-induced respiratory plasticity in humans http://ow.ly/MDiCk

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Section: Ahvr and Ahcvrsupporting

confidence: 84%

Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation

et al. 2015

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“…TNF-α = tumour necrosis factor-α; IL-10 = interleukin 10; BMI = body mass index; AHI = apnoea-hypopnoea index; O 2 sat = oxygen saturation inflammatory markers in OSAHS patients may be more related to other factors such as obesity or nocturnal arousal. 15 Studies from various laboratories and clinical environments suggest that OSAHS is an inflammatory disorder. The increase in proinflammatory cytokine production in OSAHS patients can have important consequences for patient outcomes, especially with regard to the increased risk for developing atherosclerosis, and cardiovascular and cerebrovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Tumour necrosis factor-α/interleukin-10 ratio in patients with obstructive sleep apnoea hypopnoea syndrome

et al. 2014

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Objective: To explore the significance of the tumour necrosis factor-α/interleukin-10 ratio and the effect of continuous positive airway pressure in patients with different degrees of obstructive sleep apnoea hypopnoea syndrome severity.Method: This study comprised 135 patients with obstructive sleep apnoea hypopnoea syndrome and 94 control subjects.Results: Tumour necrosis factor-α and tumour necrosis factor-α/interleukin-10 ratio values were significantly higher in the obstructive sleep apnoea hypopnoea syndrome group than in the control group, but interleukin-10 was significantly lower. Tumour necrosis factor-α/interleukin-10 ratio values increased in line with the severity of obstructive sleep apnoea hypopnoea syndrome. In multivariate analysis, the tumour necrosis factor-α/ interleukin-10 ratio correlated positively with the apnoea-hypopnoea index and all indices of obstructive sleep apnoea hypopnoea syndrome, except for age, body mass index and neck circumference. After one month of continuous positive airway pressure therapy, levels of tumour necrosis factor-α decreased; interleukin-10 showed no change.Conclusion: The results suggest that inflammation is activated and anti-inflammatory cytokines are decreased in obstructive sleep apnoea hypopnoea syndrome patients. Tumour necrosis factor-α/interleukin-10 ratio may prove useful for severity monitoring and management of obstructive sleep apnoea hypopnoea syndrome patients, and may reduce the need for polysomnography.

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“…During sleep, SAHS patients suffer from cycles of hypoxia and reoxygenation, upper airway occlusion, intrathoracic pressure swings, sleep fragmentation with arousals, and intermittent hypercapnia [11]. This phenomenon increases the oxidative stress, which could trigger an inflammatory response linking SAHS and metabolic disorders [37]. Furthermore, weight loss might counteract SAHS [49].…”

Section: Introductionmentioning

confidence: 99%

Impact of intermittent hypoxia and exercise on blood pressure and metabolic features from obese subjects suffering sleep apnea-hypopnea syndrome

et al. 2015

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Strategies designed to reduce adiposity and cardiovascular-accompanying manifestations have been based on nutritional interventions conjointly with physical activity programs. The aim of this 13-week study was to investigate the putative benefits associated to hypoxia plus exercise on weight loss and relevant metabolic and cardiorespiratory variables, when prescribed to obese subjects with sleep apnea syndrome following dietary advice. The participants were randomly distributed in the following three groups: control, normoxia, and hypoxia. All the subjects received dietary advice while, additionally, normoxia group was trained under normal oxygen concentration and Hypoxia group under hypoxic conditions. There was a statistically significant decrease in fat-free mass (Kg) and water (%) on the control compared to normoxia group (p < 0.05 and p < 0.01, respectively). Body weight, body mass index, and waist circumference decreased in all the groups after the study. Moreover, leukocyte count was increased after the intervention in hypoxia compared to control group (p < 0.05). There were no statistically significant variations within groups in other variables, although changes in appetite were found after the 13-week period. In addition, associations between the variations in the leukocyte count and fat mass have been found. The hypoxia group showed some specific benefits concerning appetite and cardiometabolic-related measurements as exertion time and diastolic blood pressure, with a therapeutical potential.

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Effects Of 10 Days Of Modest Intermittent Hypoxia On Circulating Measures Of Inflammation In Healthy Humans

Cited by 6 publications

References 0 publications

Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation

Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation

Tumour necrosis factor-α/interleukin-10 ratio in patients with obstructive sleep apnoea hypopnoea syndrome

Impact of intermittent hypoxia and exercise on blood pressure and metabolic features from obese subjects suffering sleep apnea-hypopnea syndrome

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