Effects of 1 MHz Therapeutic Ultrasound on Limb Blood Flow and Microvascular Reactivity: A Randomized Pilot Trial

Waters, Megan; Miljkovic, Branko; Rascon, Jozelyn; Gomez, Manuel; Gurovich, Alvaro N.

doi:10.3390/ijerph182111444

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…LIFUS can be used as a physical factor analgesic method for postpartum breast pain. The results showed that most participants did not develop recurrent pain after three consecutive treatments, indicating that LIFUS not only has an analgesic effect on the breast but may also have the effect of dredging the breast and promoting circulation to resolve pain (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 95%

Preliminary study on the effect of ultrasound on postpartum uterine involution and breast pain: a randomised controlled trial

Wei

Yue²,

Meng

et al. 2023

Preprint

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Objectives To evaluate the safety and efficacy of low-intensity focused ultrasound (LIFUS) therapy in promoting fundus descent and relieving postpartum breast pain compared with sham treatment. Methods A multicentre, randomised, sham-controlled, blinded trial was conducted. A total of 176 participants who had normal prenatal check-ups and met the inclusion and exclusion criteria were enrolled from three medical centres and subsequently randomised into the LIFUS or sham group. All participants provided three times treatment, LIFUS signal to the uterus and breast site through coupling gel, wherein a ultrasound signal output was absent in sham group. Fundal height measurement and breast pain score were performed after each treatment. The primary outcome was uterine involution, which was presented by measuring the fundal height of the uterus. The visual analogue scale (VAS) score, as a secondary outcome, was used to simultaneously assess breast pain and the correlation between breast pain and fundal height as the outcome. Results All participants were randomised into the LIFUS group (n = 88) or sham group (n = 88), of whom seven did not complete treatment. Overall, a statistically significant difference was noted in the rate and index of fundus descent after each treatment. The rate and index of fundus descent were more significant following the second (rate: 1.3 cm/d; index: 0.13, P < 0.001) and third (rate: 1.71 cm/d; index: 0.26, P < 0.001) treatments in the LIFUS group. VAS scores, which were based on the continuous variable for the baseline, first, second, and third treatments in the LIFUS (2.23, 1.16, 0.78, and 0.28 points, respectively) and sham groups (2.09, 1.64, 1.98, and 2.49 points, respectively), had a statistically significant difference between the two groups. Meanwhile, the differences in VAS score classification variables between the two groups were statistically significant. After the third treatment, a significant correlation was observed between the VAS score decrease and fundus descent rate; the more the VAS score decreased, the faster was the fundal decline rate in the LIFUS group. Conclusions LIFUS therapy is safe and effective, which contributes to accelerated uterine involution and relieved postpartum breast pain. The study has registered in the Chinese Clinical Trial Registry (ChiCTR2100049586) at 05/08/2021.

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Section: Discussionmentioning

confidence: 95%

Preliminary study on the effect of ultrasound on postpartum uterine involution and breast pain: a randomised controlled trial

Wei

Yue²,

Meng

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Preliminary study of the effect of low-intensity focused ultrasound on postpartum uterine involution and breast pain in puerperal women: a randomised controlled trial

Wei,

Yue,

Meng

et al. 2024

Sci Rep

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To evaluate the safety and efficacy of low-intensity focused ultrasound (LIFU) therapy in facilitating fundus descent and relieving postpartum breast pain compared with sham treatment. A multicentre, randomised, sham-controlled, blinded trial was conducted. A cohort of 176 eligible participants, who had normal prenatal check-ups and met the inclusion and exclusion criteria, were recruited from three medical centres and subsequently randomized into either the LIFU or sham group. All participants received three treatment sessions, wherein LIFU signal was applied to the uterus and breast sites using coupling gel, with the absence of ultrasound signal output in the sham group. Fundal height measurement and breast pain score were performed after each treatment. The primary outcome, uterine involution, was presented by measuring the fundal height of the uterus. The visual analogue scale (VAS) score, as a secondary outcome, was used to assess breast pain and determine the correlation between breast pain and fundal height as the outcome simultaneously. All participants were randomly assigned to either the LIFU group (n = 88) or sham group (n = 88), with seven individuals not completing the treatment. Overall, a statistically significant difference was noted in the rate and index of fundus descent after each treatment. The rate and index of fundus descent showed greater significance following the second treatment (rate: 1.5 (1.0, 2.0) cm/d; index: 0.15 (0.1, 0.18), P < 0.001) and third treatment (rate: 1.67 (1.33, 2.0) cm/d; index: 0.26 (0.23, 0.3), P < 0.001) in the LIFU group. VAS scores, which were based on the continuous variables for the baseline, first, second, and third treatments in the LIFU group (2.0 (2.0, 3.0), 1.0 (0.0, 2.0), 0.0 (0.0, 1.0), and 0.0 (0.0, 0.0) points, respectively), and the sham group (2.0 (2.0, 2.0), 2.0 (1.0, 2.0), 2.0 (1.0, 3.0), and 3.0 (1.0, 3.0) points, respectively), showed a statistically significant difference between the two groups. Meanwhile, the discrepancies in VAS score classification variables between the two groups were statistically significant. After the third treatment, a notable correlation was observed between the VAS score decrease and fundus descent rate; the more the VAS score decreased, the faster was the fundal decline rate in the LIFU group. LIFU therapy is safe and effective, contributing to the acceleration of uterine involution and the relief of postpartum breast pain.Trial ID The study has registered in the Chinese Clinical Trial Registry (ChiCTR2100049586) at 05/08/2021.

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A Randomized Trial of Therapeutic Ultrasound on Pain, Tenderness, and Muscle Stiffness Using a High and Low Intensity Model of Delayed Onset Muscle Soreness

Gabison,

Nussbaum

2024

Physiotherapy Canada

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Purpose: This study evaluated ultrasound (US) effectiveness in an experimental model of soft tissue injury, and examined the model, delayed onset muscle soreness (DOMS), as a variable in the outcome. Methods: One hundred and twenty females completed 30 repetitions (low-DOMS) or 70 repetitions (high-DOMS) of eccentric contractions of biceps brachii muscles and received one of four protocols: no US (control), placebo US, or 3 MHz US, pulsed 20% duty cycle, at either 0.6 W/cm2, spatial-average temporal-peak intensity (SATP) (0.12 W/cm2, spatial-average temporal-average intensity (SATA)) or 1.0 W/cm2, SATP (0.2 W/cm2 SATA). A further 60 females completed a low-DOMS protocol and received one of three protocols: placebo US, or continuous wave 3 MHz US at either 0.2 or 0.4 W/cm2, SATP/SATA. US was applied to biceps muscles for 5 minutes on days 1 to 3. Muscle soreness, tenderness, and stiffness were measured pre-DOMS induction and at 24, 48, and 72 hours post-induction. Results: Pulsed US, 20% duty cycle, at 0.6 W/cm2, SATP, (0.12 W/cm2, SATA) reduced muscle soreness in a low-DOMS but not in a high-DOMS protocol. Continuous wave US at 0.4 W/cm2, SATP/SATA reduced tenderness. Continuous US at 0.2 W/cm2, SATP/SATA was marginally effective on stiffness and tenderness. Conclusion: The results have implications for US management of acute soft tissue injury and the use of DOMS as an experimental model for soft tissue inflammation.

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Effects of 1 MHz Therapeutic Ultrasound on Limb Blood Flow and Microvascular Reactivity: A Randomized Pilot Trial

Cited by 3 publications

References 28 publications

Preliminary study on the effect of ultrasound on postpartum uterine involution and breast pain: a randomised controlled trial

Preliminary study on the effect of ultrasound on postpartum uterine involution and breast pain: a randomised controlled trial

Preliminary study of the effect of low-intensity focused ultrasound on postpartum uterine involution and breast pain in puerperal women: a randomised controlled trial

A Randomized Trial of Therapeutic Ultrasound on Pain, Tenderness, and Muscle Stiffness Using a High and Low Intensity Model of Delayed Onset Muscle Soreness

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