Effects of 1 mA and 2 mA transcranial direct current stimulation on working memory performance in healthy participants

Papazova, Irina; Strube, Wolfgang; Wienert, Aida; Henning, Bettina; Schwippel, Tobias; Fallgatter, Andreas J.; Padberg, Frank; Falkai, Peter; Plewnia, Christian; Hasan, Alkomiet

doi:10.1016/j.concog.2020.102959

Cited by 16 publications

(9 citation statements)

References 59 publications

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“…However, few studies have explored the effects of different intensities of tDCS on PFC. Papazova, Strube, Wienert, Henning, Schwippel, Fallgatter, Padberg, Falkai, Plewnia and Hasan [ 36 ] did not show differences in the working memory between online tDCS at 1 and 2 mA in the DLPFC. Ehrhardt, Filmer, Wards, Mattingley and Dux [ 39 ], who also used online tDCS and stimulation at 0.7, 1 and 2 mA intensities during DT (cognitive–cognitive) training sessions, did not show better DT performance when increasing intensity.…”

Section: Discussionmentioning

confidence: 99%

“…The methods to apply this technique can be performed during the execution (online) or before the execution of the task (offline), measuring the direct or short/long term effects, respectively [ 31 ]. There is currently controversy about the most appropriate type of intensity, since previous studies have compared different intensities showing similar results [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. In addition, higher intensities do not necessarily result in better effects [ 40 , 41 , 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Transcranial Direct Current Stimulation on Brain Electrical Activity, Heart Rate Variability, and Dual-Task Performance in Healthy and Fibromyalgia Women: A Study Protocol

Gomez-Alvaro

Villafaina

León-Llamas

et al. 2022

Behavioral Sciences

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People with fibromyalgia could experience physical and cognitive impairments. Furthermore, when performing two tasks at the same time, people with fibromyalgia showed a higher dual-task cost compared to a single task than healthy people. This may result in poorer performance of activities of daily living that are commonly presented as a combination of two or more tasks. Transcranial direct current stimulation (tDCS) is a promising nonpharmacological therapy. However, there is controversy regarding the intensities and the effectiveness of this therapy. Thus, the present study will aim: (1) to compare the effectiveness and the impact of two tDCS intensities (1 mA and 2 mA) on cognitive, motor, brain functions, and cardiac autonomic modulation; (2) to study the impact of tDCS on the dual-task performance and creativity after applying tDCS in dorsolateral prefrontal cortex. In this study, 26 women will participate and will be divided into two groups: women with fibromyalgia (n = 13), and healthy controls (n = 13). A reduction in cognitive-motor interference in dual-task performance is expected, as well as a modification in neurophysiological parameters and an improvement in cardiac autonomic modulation. Lastly, no different effects are expected depending on the stimulation intensity applied. The obtained results will help to determine if tDCS in the dorsolateral prefrontal cortex could improve the occupational performance of women with fibromyalgia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Transcranial Direct Current Stimulation on Brain Electrical Activity, Heart Rate Variability, and Dual-Task Performance in Healthy and Fibromyalgia Women: A Study Protocol

Gomez-Alvaro

Villafaina

León-Llamas

et al. 2022

Behavioral Sciences

View full text Add to dashboard Cite

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“…However, null results of tDCS on cognition have also been reported [35,44]. Among the factors that seem to influence the efficacy of tDCS in HY, the increased task load was shown to play an important role [31,32,37,45]. Of note, the most common target of previous tDCS studies was the dorsolateral prefrontal cortex (DLPFC) [18,42,46].…”

Section: Discussionmentioning

confidence: 99%

Modulation of Working Memory and Resting-State fMRI by tDCS of the Right Frontoparietal Network

et al. 2021

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Many cognitive functions, including working memory, are processed within large-scale brain networks. We targeted the right frontoparietal network (FPN) with one session of transcranial direct current stimulation (tDCS) in an attempt to modulate the cognitive speed of a visual working memory task (WMT) in 27 young healthy subjects using a double-blind crossover design. We further explored the neural underpinnings of induced changes by performing resting-state fMRI prior to and immediately after each stimulation session with the main focus on the interaction between a task-positive FPN and a task-negative default mode network (DMN). Twenty minutes of 2 mA anodal tDCS was superior to sham stimulation in terms of cognitive speed manipulation of a subtask with processing of objects and tools in unconventional views (i.e., the higher cognitive load subtask of the offline WMT). This result was linked to the magnitude of resting-state functional connectivity decreases between the stimulated FPN seed and DMN seeds. We provide the first evidence for the action reappraisal mechanism of object and tool processing. Modulation of cognitive speed of the task by tDCS was reflected by FPN-DMN cross-talk changes.

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“…The current intensity was 1 mA, applied constantly. There is evidence that in arrangements requiring different cognitive loads, there are no differences between the effects of stimulation at 1 mA and 2 mA [ 20 ]. This appears comparable to the requirements in the present study, where different numbers of distractors must be ignored in different conditions.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Transcranial Direct Current Stimulation on Error Rates in the Distractor-Induced Deafness Paradigm

2022

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To further understand how consciousness emerges, certain paradigms inducing distractor-induced perceptual impairments are promising. Neuro-computational models explain the inhibition of conscious perception of targets with suppression of distractor information when the target and distractor share the same features. Because these gating mechanisms are controlled by the prefrontal cortex, transcranial direct current stimulation of this specific region is expected to alter distractor-induced effects depending on the presence and number of distractors. To this end, participants were asked to perform an auditory variant of the distractor-induced blindness paradigm under frontal transcranial direct current stimulation (tDCS). Results show the expected distractor-induced deafness effects in a reduction of target detection depending on the number of distractors. While tDCS had no significant effects on target detection per se, error rates due to missed cues are increased under stimulation. Thus, while our variant led to successful replication of behavioral deafness effects, the results under tDCS stimulation indicate that the chosen paradigm may have difficulty too low to respond to stimulation. That the error rates nevertheless led to a tDCS effect may be due to the divided attention between the visual cue and the auditory target.

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Effects of 1 mA and 2 mA transcranial direct current stimulation on working memory performance in healthy participants

Cited by 16 publications

References 59 publications

Effects of Transcranial Direct Current Stimulation on Brain Electrical Activity, Heart Rate Variability, and Dual-Task Performance in Healthy and Fibromyalgia Women: A Study Protocol

Effects of Transcranial Direct Current Stimulation on Brain Electrical Activity, Heart Rate Variability, and Dual-Task Performance in Healthy and Fibromyalgia Women: A Study Protocol

Modulation of Working Memory and Resting-State fMRI by tDCS of the Right Frontoparietal Network

The Effect of Transcranial Direct Current Stimulation on Error Rates in the Distractor-Induced Deafness Paradigm

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