Effects of 1,25-Dihydroxycholecalciferol on Calcium Absorption, Muscle Weakness, and Bone Disease in Chronic Renal Failure

Henderson, R. G.; Ledingham, J. G. G.; Oliver, D O; Small, D. G.; Russell, R. G. G.; Smith, Rosamund C.; Walton, R. J.; Preston, Christopher J.; Warner, G. T.; Norman, Anthony W.

doi:10.1016/s0140-6736(74)93149-3

Cited by 167 publications

(38 citation statements)

References 16 publications

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“…A few studies have examined the effects of vitamin D treatment on muscle and muscle function in patients with ESRD [17][18][19][20]. Although the sample sizes of these studies are quite small (n = 8 to 27), collectively they lend support to our observation that ESRD patients who receive treatment with active vitamin D for the treatment of SHPT have larger muscle size and greater strength.…”

Section: Discussionsupporting

confidence: 68%

“…A few studies have examined the effects of vitamin D treatment on muscle function in patients with ESRD [17][18][19][20]. Although collectively these studies provide evidence that treatment with vitamin D may have a positive effect on various aspects of muscle function in patients with ESRD, small sample size, poorly described study designs, and vague descriptions of clinical outcomes related to strength make it difficult to draw any firm conclusions or to generalize the results.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Vitamin D and Muscle Size and Strength in Patients on Hemodialysis

Gordon

Sakkas

Doyle

et al. 2007

Journal of Renal Nutrition

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OBJECTIVE-Vitamin D has various actions in skeletal muscle. The purpose of this study was to compare lower limb muscle size and strength in hemodialysis (HD) patients being treated with 1,25-dihydroxyvitamin D (calcitriol) or a 1,25-dihydroxyvitamin D analog (paricalcitol) to HD patients who were receiving none.DESIGN-This was a retrospective cross-sectional study. SETTING-Outpatient hemodialysis centers.PATIENTS-HD patients receiving calcitriol or paricalcitol (active vitamin D) for control of secondary hyperparathyroidism (VitD, n = 49) were compared to HD patients who were not (n = 30).MAIN OUTCOME MEASURES-Cross-sectional areas (CSA) of thigh and tibialis anterior muscles by magnetic resonance imaging (MRI), and three measures of strength; three-repetition maximum (3RM) for knee extension (isotonic), peak torque of knee extensors (isokinetic), and maximal voluntary contraction (MVC) of the ankle dorsiflexor muscles (isometric).RESULTS-There were no differences in age, weight, dialysis vintage, or intact parathyroid hormone levels between the groups, although serum albumin was higher in the VitD group (p <0.05). Patients in the VitD group had larger thigh muscle CSA (p < 0.05) and were stronger across all strength measures (p< 0.05) after controlling for age and gender (ANCOVA). When all analyses were subsequently adjusted for serum albumin concentration, only the difference in 3RM knee extension strength lost significance. There were no significant differences in any measurements between patients who received calcitriol or paricalcitol.CONCLUSION-Treatment with active vitamin D was associated with greater muscle size and strength in this cohort of HD patients.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Relationship Between Vitamin D and Muscle Size and Strength in Patients on Hemodialysis

Gordon

Sakkas

Doyle

et al. 2007

Journal of Renal Nutrition

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“…In a previous stiurly, the muscle fibers of rats kept vitamilin D deficienit for 18 wk were smaller than those of norinal controls (36). In our study, muscle fibers ofgroup 1-noD and group 4 Uremic humanis are often weak (39,40), anid, on1 occasion, weakness is redluced bv therapy with 1,2diOHD3 (39). It is likely that the 1,25diOHD3-responsive uremics were deficient in this vitamin D metabolite becauise of a diminution in the capacitv of their kidneys to carry out one hydroxylationi of 25-hydroxyvitamin D3 (2).…”

Section: Resultssupporting

confidence: 48%

Skeletal Muscle Calcium Metabolism and Contractile Force in Vitamin D-deficient Chicks

Pleasure¹,

Wyszynski²,

Sumner³

et al. 1979

J. Clin. Invest.

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“…In chronic renal insufficiency, where the kidney fails to produce the active hormonal metabolite, both la-OH-D3 and 1,25(OH),D3 (in doses of the order of 1 pg daily) have been shown to be effective in correcting the biochemical abnormalities, and radiographic evidence of bone healing has also been noted (Brickman et al, 1974a, b;Henderson et al, 1974;Silverberg et al, 1975;Evans er al., 1976;Chalmers et al, 1973;Peacock et al, 1974;Chan et al, 1975). Intestinal calcium absorption increases, the serum calcium levels return to normal and the elevated levels of serum alkaline phosphatase and immunoreactive parathyroid hormone are reduced.…”

Section: The Clinical Use Of Active Metabolites and Analogues Of Cholmentioning

confidence: 99%

Vitamin D

MacIntyre

Evans

Larkins

1977

Clinical Endocrinology

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Effects of 1,25-Dihydroxycholecalciferol on Calcium Absorption, Muscle Weakness, and Bone Disease in Chronic Renal Failure

Cited by 167 publications

References 16 publications

Relationship Between Vitamin D and Muscle Size and Strength in Patients on Hemodialysis

Relationship Between Vitamin D and Muscle Size and Strength in Patients on Hemodialysis

Skeletal Muscle Calcium Metabolism and Contractile Force in Vitamin D-deficient Chicks

Vitamin D

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