Effects Induced by Phenobarbital and Phenytoin on the Activity of Pseudocholinesterase in Serum and Liver in the Mouse

E, Puche; Serrana, Herminia García de la; Mota, C

doi:10.1111/j.1600-0773.1990.tb00790.x

Cited by 2 publications

(1 citation statement)

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“…Some authors have reported that despite the claim that most psychopharmacological agents do not affect PChE levels, some medications cause hepatic and serum PChE activity. 10 , 12 In our study, there was no correlation determined between the cases’ diagnoses and PChE enzyme levels.…”

Section: Discussioncontrasting

confidence: 65%

Pseudocholinesterase levels in patients under electroconvulsive therapy

Küçükosman

Pişkin

Hancı

et al. 2018

SMJ

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Objectives:In this study, we aimed to retrospectively assess the correlation of pseudocholinesterase (PChE) levels with age, gender, body weight and diagnosed psychiatric diseases in electroconvulsive therapy (ECT) cases.Methods:This retrospective study was conducted at Bülent Ecevit University Hospital, Zonguldak, Turkey, between 2007 and 2011. In the study, 193 ECT case files were retrospectively scanned to evaluate PChE values before ECT and other file information.Results:There was no difference between gender in terms of PChE levels. Correlation analysis determined a weakly positive correlation between age (p=0.013; correlation coefficient [cc]: 0.178) and body weight (p<0.001; cc: 0.273) and PChE levels. No correlation was found between age, gender, weight or psychiatric diagnosis, and PChE levels.Conclusion:Neuromuscular blockage is a significant factor that increases patient safety, while increasing the efficacy of ECT. In choosing muscle relaxant agents, both patient factors and the pharmacological properties of the neuromuscular blocker should be considered. We think that in situations with delayed recovery of ECT cases without identified PChE levels, low PChE levels must be considered.

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Section: Discussioncontrasting

confidence: 65%