Effects in Premature Infants of Normalizing Breath H2 Concentrations with CO2

Cl, Kien; Ea, Liechty; Dz, Myerberg; Mullett,

doi:10.1097/00005176-198703000-00022

Cited by 15 publications

(4 citation statements)

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“…In such applications, the mass flow controller can be purchased for larger flow rates, and a vacuum pump can be used if necessary to produce the necessary flow rate. Obviously, the instrument for mea suring the CO2 concentration adds an addi tional cost, but this instrument may have oth er uses in a department or laboratory, for example in normalizing the results of breath hydrogen testing [11]. In addition, the config uration of the system described in this paper (interval sampling of the breath excretion) means that a laboratory remote from the nurs ery could be used for CO2 analysis and data reduction.…”

Section: Discussionmentioning

confidence: 99%

A Portable Device for Estimating the Rate of CO<sub>2</sub> Production in Preterm Infants

et al. 1995

Neonatology

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We developed a simple flow-through system for measuring the net rate of pulmonary excretion of CO₂ (VCO₂). Its components, connected in series by plastic tubing, are the following: plastic oxygen hood, suction flask used both as a mixing and sampling chamber, Brooks mass flow controller, and wall suction. Gas aliquots withdrawn from the sampling flask are analyzed for CO₂ concentration in the laboratory. The system was validated by measuring over a 60-min period the evolution of CO₂ from the reaction of sodium carbonate with phosphoric acid. In 9 trials, the mean recovery of CO₂ was 99.8%. In 14 studies in 11 preterm infants, we evaluated the reproducibility of duplicate measurements of CO₂ production on consecutive days; in 9 of the studies, the coefficient of variation was < 5%, but in other 5 studies, it ranged from 7.7 to 35.8%. We believe that this device might have both research and clinical applicability.

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Section: Discussionmentioning

confidence: 99%

A Portable Device for Estimating the Rate of CO<sub>2</sub> Production in Preterm Infants

et al. 1995

Neonatology

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“…The concentration of H 2 and CO 2 in the breath samples was measured (Quintron Microlyzer, Model SC; Quintron Instruments). The breath concentration of H 2 was expressed as a ratio to the CO 2 concentration (5%) in alveolar air in order to normalize the data for incomplete alveolar breath collection and contamination with room air 19 . To determine the limit of detection for BH2, twice the SD was calculated from a set of 5 replicate samples of a standard gas (average BH2 concentration of 42 ppm).…”

Section: Methodsmentioning

confidence: 99%

Diarrhea in Severely Burned Children

Thakkar

Kien

Rosenblatt

et al. 2005

J Parenter Enteral Nutr

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“…Breath was collected using a nasal cannula technique (7). A soft rubber sleeve made from a urinary catheter (= 1 em long) was inserted into the external nares on one side.…”

Section: Breath Hydrogen Measurementmentioning

confidence: 99%

“…The concentration of hydrogen in the breath (BH 2 ) has been used as an indirect indicator of the extent to which lactose is not hydrolyzed in the small intestine and is subjected to colonic fermentation (5,6). Premature infants receiving nutritionally adequate intakes of formulas containing lactose generally exhibit high BH 2 suggesting that a significant fraction of lactose reaches the colon in such infants (6)(7)(8). Depending on the coefficient of absorption of hydrogen in the colon, the actual estimate of the fraction of dietary lactose which is fermented in premature infants varies from ~12-19% (9) to 66% (6).…”

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confidence: 99%

Efficient Assimilation of Lactose Carbon in Premature Infants

Kien,

Kepner,

Grotjohn

et al. 1992

J. pediatr. gastroenterol. nutr.

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SummaryPrevious studies have shown that there is minimal fecal excretion of carbohydrate energy in premature infants with high breath H2 concentrations, implying that the colon plays an important role in salvaging lactose energy. The present study extends this work by using a stable isotope method for serial assessment of lactose carbon excretion. Thus, in nine premature infants (30–32 weeks of gestation and 11–36 days of age), we conducted 23 longitudinal studies of breath hydrogen concentration and the cumulative fecal excretion of 13C derived from a single dose of [D‐1‐13C]lactose. The ranges of values (X ± SD) for breath hydrogen concentration and lactose absorption were respectively 4–440 ppm/5% CO2 (92 ± 100) and 82–100% tracer dose (98.4 ± 3.9). In 21 studies, lactose carbon excretion was <2% of the dose. There was a significant correlation between postnatal age and breath hydrogen concentration (R = 0.48; p = 0.02). These studies suggest that colonic fermentation activity is adequate for efficient colonic salvage of lactose even during the second week of life.

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Effects in Premature Infants of Normalizing Breath H2 Concentrations with CO2

Cited by 15 publications

References 0 publications

A Portable Device for Estimating the Rate of CO<sub>2</sub> Production in Preterm Infants

A Portable Device for Estimating the Rate of CO<sub>2</sub> Production in Preterm Infants

Diarrhea in Severely Burned Children

Efficient Assimilation of Lactose Carbon in Premature Infants

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