Effects in cattle of genetic variation within the IGF1R gene on the superovulation performance and pregnancy rates after embryo transfer

Yang, Liguo; Riaz, Hasan; Tang, Kai-Fu; Chen, Long; Li, Shujing

doi:10.1016/j.anireprosci.2013.10.008

Cited by 10 publications

(10 citation statements)

References 46 publications

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“…In dairy cattle, treatment with bovine somatotropin increases fertility, which is likely mediated by increases in IGF1 [ 63 ]. Of note, polymorphisms in IGF1R were associated with a greater pregnancy rate in Luxi and Chinese Holstein cattle [ 62 , 64 ]. Similarly, another leading edge gene, collagen type IV alpha 1 chain ( COL4A1 ), is upregulated in day 18 endometrial caruncle tissue in pregnant cattle suggesting a role for COL4A1 in remodeling of the uterus during pregnancy for conceptus implantation and placentation [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle

et al. 2017

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Infertility and subfertility negatively impact the economics and reproductive performance of cattle. Of note, significant pregnancy loss occurs in cattle during the first month of pregnancy, yet little is known about the genetic loci influencing pregnancy success and loss in cattle. To identify quantitative trait loci (QTL) with large effects associated with early pregnancy loss, Angus crossbred heifers were classified based on day 28 pregnancy outcomes to serial embryo transfer. A genome wide association analysis (GWAA) was conducted comparing 30 high fertility heifers with 100% success in establishing pregnancy to 55 subfertile heifers with 25% or less success. A gene set enrichment analysis SNP (GSEA-SNP) was performed to identify gene sets and leading edge genes influencing pregnancy loss. The GWAA identified 22 QTL (p < 1 x 10−5), and GSEA-SNP identified 9 gene sets (normalized enrichment score > 3.0) with 253 leading edge genes. Network analysis identified TNF (tumor necrosis factor), estrogen, and TP53 (tumor protein 53) as the top of 671 upstream regulators (p < 0.001), whereas the SOX2 (SRY [sex determining region Y]-box 2) and OCT4 (octamer-binding transcription factor 4) complex was the top master regulator out of 773 master regulators associated with fertility (p < 0.001). Identification of QTL and genes in pathways that improve early pregnancy success provides critical information for genomic selection to increase fertility in cattle. The identified genes and regulators also provide insight into the complex biological mechanisms underlying pregnancy establishment in cattle.

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Section: Resultsmentioning

confidence: 99%

Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle

et al. 2017

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“…The receptors for IGF-1 are present on uterus and embryo. It was also found that the polymorphism in IGF1R is associated with superovulation traits and indicated that the IGFIR gene can be used as a potential marker for donor selection in cattle [28]. Hence, the growth and development of embryos are affected by serum/plasma IGF-1 concentration.…”

Section: Discussionmentioning

confidence: 99%

Effect of insulin or insulin-like growth factor-I administration at mid-luteal phase of the estrous cycle during superovulation on hormonal profile of Sahiwal cows

2018

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Aim:The present study was designed to study the effect of insulin and insulin-like growth factor-1 (IGF-I) administration during luteal phase of the estrous cycle on the hormonal profile of Sahiwal embryo donor cows during superovulation.Materials and Methods:Cows (n=18) were selected and divided into three groups; control (n=6, untreated), T-I (n=6, insulin-treated), and T-II (n=6, IGF-I treated). Insulin and IGF-I were given S/C on 5th, 6th, 7th, and 8th days of estrous cycle. Superovulatory treatment was started on day 9th of the estrous cycle. With the sixth dose of follicle-stimulating hormone, prostaglandin was injected to induce superovulatory heat. The superovulated cows were bred, and superovulatory response of each animal was recorded. The embryos were collected non-surgically on the 7th day of superovulatory estrus. About 15 ml blood without anticoagulant was collected on days 5, 7, 9, 11, 13, 15, 17, 19, and 21 or day of embryo recovery where day 0 of estrous cycle was taken as day of estrus. Serum was separated, centrifuged, and transferred into sterilized serum vials. All samples were stored at −20°C till analysis. Progesterone, insulin, and IGF-I were estimated in blood serum by radioimmunoassay using radioimmunoassay kits.Results and Discussion:The mean concentration of progesterone on days 7 and 11, insulin on days 7 and 9, and IGF-I on days 5, 7, 9, 11, and 15 was significantly higher in insulin-treated T-I groups as compared to untreated control.Conclusion:It may be concluded that exogenous insulin administration during mid-luteal phase may be helpful in follicular and embryonic development through modulation of progesterone, insulin, and IGF-I in indigenous (Bos indicus) Sahiwal embryo donor cows.

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“…El IGFR1 media las acciones biológicas de IGF1 y 2, teniendo un rol importante en el desarrollo folicular (Echternkamp et al, 2004;Yang et al, 2013). En folículos quísticos bovinos existe una mayor expresión de IGFR1 en células de la granulosa y niveles crecientes del mismo a medida que aumenta el tamaño del folículo (Lucy, 2008;Silva et al, 2009;.…”

Section: Expresión De Los Diferentes Componentes Del Sistema Igf En Lunclassified

Participación del sistema IGF en la patogenia de la enfermedad quística bovina

Rodríguez¹,

Salvetti²,

Ortega³

et al. 2016

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La enfermedad quística ovárica (COD) es una de las principales causas de falla reproductiva y de infertilidad, y constituye uno de los de los trastornos reproductivos más frecuentes en vacas lecheras de alta producción. El desarrollo de esta enfermedad está asociado a un desequilibrio en el eje hipotalámico-hipofisario-gonadal en el cual factores endocrinos, entre ellos el sistema de factores de crecimiento análogos a insulina (IGF), participan en el desarrollo folicular, diferenciación celular y la secreción de hormonas ováricas. Considerando al sistema IGF como un importante regulador del crecimiento y funcionalidad folicular, evaluamos la participación de componentes del sistema IGF en el desarrollo de la COD. Las alteraciones en diferentes componentes del sistema IGF que podrían afectar al normal funcionamiento del ovario participando en el desarrollo de la COD en bovinos.

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Effects in cattle of genetic variation within the IGF1R gene on the superovulation performance and pregnancy rates after embryo transfer

Cited by 10 publications

References 46 publications

Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle

Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle

Effect of insulin or insulin-like growth factor-I administration at mid-luteal phase of the estrous cycle during superovulation on hormonal profile of Sahiwal cows

Participación del sistema IGF en la patogenia de la enfermedad quística bovina

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