Effects and Safety of Intra-Articular Sodium Hyaluronate Injection for the Treatment of Ankle Osteoarthritis: A Prospective Clinical Trial

Lee, Gun-Woo; Kwak, Woo-Kyoung

doi:10.1053/j.jfas.2021.09.012

Cited by 8 publications

(7 citation statements)

References 47 publications

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“… 27 − 29 In a recent study investigating the potential benefits of intra-articular Hyruan Plus injections in patients with early or intermediate-grade ankle OA who were unresponsive to conventional medications, three weekly injections of hyaluronate were not only safe but also effective in reducing pain and enhancing functional outcomes. 30 This result further highlights the potential application of HA in aiding cartilage repair and maintenance.…”

Section: Discussionmentioning

confidence: 77%

“…Moreover, prior research reveals the capacity of HA to inhibit proinflammatory mediators in chondrocytes, thereby reducing MMPs, especially MMP1, 3, and 13, which play crucial roles in cartilage breakdown . Numerous reports have indicated that intra-articular HA has disease-modifying properties on cartilage, including the suppression of cartilage degeneration, enhanced chondrocyte density and morphology, and the prevention of cartilage surface fissures and cracks. − In a recent study investigating the potential benefits of intra-articular Hyruan Plus injections in patients with early or intermediate-grade ankle OA who were unresponsive to conventional medications, three weekly injections of hyaluronate were not only safe but also effective in reducing pain and enhancing functional outcomes . This result further highlights the potential application of HA in aiding cartilage repair and maintenance.…”

Section: Discussionmentioning

confidence: 99%

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Hyaluronic Acid Viscosupplement Modulates Inflammatory Mediators in Chondrocyte and Macrophage Coculture via MAPK and NF-κB Signaling Pathways

Kuppa,

Kang,

Yang

et al. 2024

ACS Omega

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Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by cartilage degeneration and synovial inflammation. Paracrine interactions between chondrocytes and macrophages play an essential role in the onset and progression of OA. In this study, in replicating the inflammatory response during OA pathogenesis, chondrocytes were treated with interleukin-1β (IL-1β), and macrophages were treated with lipopolysaccharide and interferon-γ. In addition, a coculture system was developed to simulate the biological situation in the joint. In this study, we examined the impact of hyaluronic acid (HA) viscosupplement, particularly Hyruan Plus, on chondrocytes and macrophages. Notably, this viscosupplement has demonstrated promising outcomes in reducing inflammation; however, the underlying mechanism of action remains elusive. The viscosupplement attenuated inflammation, showing an inhibitory effect on nitric oxide production, downregulating proinflammatory cytokines such as matrix metalloproteinases (MMP13 and MMP3), and upregulating the expression levels of type II collagen and aggrecan in chondrocytes. HA also reduced the expression level of inflammatory cytokines such as IL-1β, TNF-α, and IL-6 in macrophages, and HA exerted an overall protective effect by partially suppressing the MAPK pathway in chondrocytes and p65/NF-κB signaling in macrophages. Therefore, HA shows potential as a viscosupplement for treating arthritic joints.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Hyaluronic Acid Viscosupplement Modulates Inflammatory Mediators in Chondrocyte and Macrophage Coculture via MAPK and NF-κB Signaling Pathways

Kuppa,

Kang,

Yang

et al. 2024

ACS Omega

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“…To differentiate the traditionally adopted method, i.e ., passive protection , we define the present methodology as an active control . Herein, sodium hyaluronate (SH), due to its highly hygroscopic property, [ 42 ] was employed to control the residual water in the Pero‐SCs. With the addition of SH, the Pero‐SCs encapsulated, unencapsulated but stored in a N 2 atmosphere at room or high temperature all showed greatly improved stability.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Highly Stable Perovskite Solar Cells by Reducing Residual Water‐Induced Decomposition of Perovskite

Yang

Chen

et al. 2023

Chin. J. Chem.

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Comprehensive SummaryResidual water‐induced decomposition is one of the dominant reasons for the decay of power conversion efficiency (PCE) in perovskite solar cells (Pero‐SCs). To solve this problem, we introduce traces amount of sodium hyaluronate (SH) into the perovskite active layer to reduce the remaining water during the preparation of perovskite films. Unlike the traditionally adopted passive protection of perovskite from exterior water by low surface energy coatings, this study provides active control of the interior water by the addition of a water adsorbent into the perovskite films. The encapsulated Pero‐SCs with SH retain approximately 70% of their initial PCE in 4000 h, while those without SH retain 32% of their initial PCE in 1000 h under the dark and ambient atmosphere. The unencapsulated Pero‐SCs with SH stored in N2 atmosphere maintain over 94% of the initial PCE in 3000 h at room temperature away from light and remain over 88% of the initial PCE in 2000 h even the devices are heated to 70 °C. It has been proven that the improved stability is mainly due to the well‐controlled residual water in perovskite films. Concomitantly, the PCE of p‐i‐n solar cells based on (FAPbI3)0.85(MAPbBr3)0.15 is improved from 19.34% to 21.54%.

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“…20 Previous randomized controlled trials showed that intra-articular HA injection has long-term effects similar to those of intra-articular corticosteroid injection and fewer side effects. [21][22][23][24] However, to our knowledge, no report has been issued on the effect of dual injection of corticosteroid and HA for ankle OA. Thus, the purpose of this study is to prospectively evaluate the e cacy of intra-articular HA injection combined with intra-articular corticosteroid.…”

Section: Introductionmentioning

confidence: 99%

“…50,51 Lee et al performed a prospective study on 3 single weekly injections of HA in 37 patients with ankle OA 21. Baseline AOS, VAS, and American Orthopedic Foot and Ankle Society (AOFAS) ankle-hindfoot scores were compared with scores at 6 months after injection for different OA stages, determined using the modi ed Takakura classi cation.…”

mentioning

confidence: 99%

Dual Intra-articular injections of corticosteroid and hyaluronic acid are more effective than corticosteroid alone for ankle osteoarthritis

Woo,

Lee,

Hyeon

et al. 2023

Preprint

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An intra-articular corticosteroid injection is commonly administered to relieve pain for ankle osteoarthritis (OA). Corticosteroid effects are short-lived, whereas, hyaluronic acid (HA) has longer effects. We hypothesized that intra-articular injections of corticosteroid and HA would be more effective than corticosteroid alone. A randomized controlled trial was decided to investigate the hypothesis. 135 patients with OA were gathered to an intra-articular corticosteroid injection group (CS group, n = 61) or dual HA plus corticosteroid injection group (CS + HA group, n = 74). The CS group received a corticosteroid injection of 1 ml once, and the CS + HA group received 2 ml of HA and 1 ml corticosteroid on the first week, followed by 2 ml of HA on the second and third weeks. Clinical evaluations were performed before injection (baseline), 6 and 12 weeks after first injections. The Ankle Osteoarthritis Scale (AOS) was used as the primary outcome measure, and the Visual Analog Scale (VAS), Short Form health survey (SF-36), and complications used as secondary outcomes. The CS + HA group had better primary outcomes than the CS group. Remarkable secondary outcomes improvements were obtained in both groups. No complications were reported. We conclude that the corticosteroid and HA combination injection is more effective in relieving pain for ankle OA than corticosteroid alone.

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Effects and Safety of Intra-Articular Sodium Hyaluronate Injection for the Treatment of Ankle Osteoarthritis: A Prospective Clinical Trial

Cited by 8 publications

References 47 publications

Hyaluronic Acid Viscosupplement Modulates Inflammatory Mediators in Chondrocyte and Macrophage Coculture via MAPK and NF-κB Signaling Pathways

Hyaluronic Acid Viscosupplement Modulates Inflammatory Mediators in Chondrocyte and Macrophage Coculture via MAPK and NF-κB Signaling Pathways

Highly Stable Perovskite Solar Cells by Reducing Residual Water‐Induced Decomposition of Perovskite

Dual Intra-articular injections of corticosteroid and hyaluronic acid are more effective than corticosteroid alone for ankle osteoarthritis

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