Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits

Niu, Weidong; He, Guodong; Liu, Han; Qin, Xinyu

doi:10.1111/j.1440-1746.2007.05049.x

Cited by 34 publications

(27 citation statements)

References 14 publications

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“…[42][43][44] In a previous canine study performed in our lab, EA was shown to improve gastric accommodation in vagotomized dogs, 15 suggesting nonvagal mechanisms. Niu et al 38 reported that effects of EA were mediated by cholinergic nerve, nitric oxide, motilin, and cholecystokinin. Yin et al 45 showed that effects of EA at ST-36 on gastric accommodation in diabetic rats were blocked by naloxone, suggesting an opioid mechanism.…”

Section: Discussionmentioning

confidence: 98%

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Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects

Huang

Zhang²,

et al. 2016

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 98%

“…37 Similar effects of EA on gastric slow waves were also found in rats and rabbits. 14,38 In healthy human, EA at ST36 and PC6 decreased the percentage Transcutaneous electroacupuncture for gastric accommodation Z Huang et al…”

Section: Discussionmentioning

confidence: 99%

Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects

Huang

Zhang²,

et al. 2016

J of Gastro and Hepatol

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“…34 An animal experiment in a rabbit model demonstrated an increased number and amplitude of spikes of gastrointestinal myoelectrical activity, and a signifi cant increase in serum CCK concentrations from 5 min before to 1 h after acupuncture. 35 However, Lee et al showed contrasting fi ndings, with CCK levels increasing during electroacupuncture, but CCK levels 5 and 10 min after stimulation not differing signifi cantly from basal CCK levels. 34 In summary, some studies demonstrate increased CCK concentrations during acupuncture while others show that CCK increases some time after acupuncture.…”

Section: Discussionmentioning

confidence: 99%

Influence of Acupuncture on Leptin, Ghrelin, Insulin and Cholecystokinin in Obese Women: A Randomised, Sham-Controlled Preliminary Trial

et al. 2012

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Background Obesity is an energy balance problem caused by overeating. Obesity treatment includes diet, exercise, behaviour treatment, pharmacotherapy and surgery; in addition, acupuncture is also an option. Objective To investigate the effect of acupuncture on weight loss and whether a brief acupuncture treatment of 5 weeks can change circulating levels of leptin, ghrelin, insulin and cholecystokinin (CCK) in obese women. Methods 40 women with a body mass index (BMI)>30 kg/m 2 were equally randomised to either an acupuncture group or a sham (nonpenetrating) acupuncture group and received treatment at LI4, HT7, ST36, ST44 and SP6 bilaterally. Both groups had two sessions of 20 min/week for a total of 10 sessions. Serum insulin, leptin, plasma ghrelin and CCK levels were measured by ELISA. Results Acupuncture treatment decreased insulin and leptin levels and induced weight loss, together with a decrease in BMI compared with sham acupuncture. Furthermore, between-group analyses demonstrated increases in plasma ghrelin and CCK levels in subjects who received acupuncture treatment. Conclusion These fi ndings suggest that acupuncture may help to regulate weight owing to its benefi cial effects on hormones such as insulin, leptin, ghrelin and CCK in obese subjects even after a few weeks of treatment. INTRODUCTIONObesity is a common health problem faced mostly in developed countries such as USA, Canada, Australia, and European countries but rates are increasing for developing countries as well. 1 The risk of diabetes, hypertension, dyslipidaemia, cardiovascular disease and sleep apnoea are greater for overweight (body mass index (BMI)>25 kg/m 2 ) and obese (BMI>30 kg/m 2 ) individuals.2 There are various treatment options in practice such as diet therapy, regulation of physical activities, behaviour treatment, pharmacotherapy, surgical procedures and acupuncture.Acupuncture is one of the treatment options in traditional Chinese medicine for a wide array of conditions and gaining attention in modern medicine. Acupuncture is thought to have been practised for several thousand years in China.3 Nowadays, even modern clinics use it for the treatment of various conditions such as obesity. NIH consensus conference statement (1998) on acupuncture stated that acupuncture shows promising results for several conditions. 4Classic acupuncture points targeted in the treatment of obesity are Neiguan (P6),5 Besides these body points, there are also two points, generally targeted for appetite control, on the ear. In addition, to these generally recognised acupoints, an acupuncturist may use different points depending on his/her own experience. 4 The evidence for the effect of acupuncture on weight loss is mixed: readers can fi nd both supporting 6 7 and refuting [8][9][10] data.Ghrelin is produced by P/D1 cells in the stomach, 11 12 increases with hunger and decreases with satiety.13 Leptin, one of the products of adipose tissue, passes through the blood-brain barrier and reduces appetite.14 Ghrelin and leptin can be called coun...

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“…EA at ST36 restored rectal distentioninduced impairment in gastric slow waves in dogs and increased the spikes in rabbits. [35][36][37] EA at ST36 improved the percentage of normal gastric slow waves as well as the percentage of tachygastria in healthy volunteers. 38 Liu et al 21 reported that 2-week TEA at ST36 decreased dyspepsia symptoms and elevated vagal activity in patients with functional dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

Central and Peripheral Effects of Transcutaneous Acupuncture Treatment for Nausea in Patients with Diabetic Gastroparesis

Sarosiek

Song

Sun

et al. 2017

J Neurogastroenterol Motil

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Background/AimsNausea, an unpleasant symptom of diabetic gastroparesis (DMGP), has been reported to be alleviated by needleless transcutaneous electrical acupuncture (TEA). Our study was designed to utilize electroencephalography (EEG) and electrogastrography (EGG) recordings to investigate the central and peripheral responses of TEA in the treatment of nausea in DMGP patients. MethodsEleven DMGP subjects underwent simultaneous EEG and EGG testing while grading the severity of nausea following 30-minute intervals of: (1) baseline, (2) visual stimulation (VS) to provoke more nausea, (3) active VS together with TEA, and (4) TEA alone, and a final 15-minute recording without any intervention. ResultsThe nausea score was increased to 5.9 ± 1.5 with VS (P < 0.05, vs 3.5 ± 1.0 at baseline), then reduced to 3.5 ± 1.2 with VS plus TEA, and to 2.5 ± 1.3 with TEA alone, while it continued at a score of 2.9 ± 1.0 post TEA (all significant, P < 0.05, vs VS without TEA). The mean percentage of normal gastric slow waves was decreased to 60.0 ± 5.7% with VS (P < 0.05, vs 66.6 ± 4.5% at baseline), then improved to 69.2 ± 4.8% with VS plus TEA, and maintained at 70 ± 3.6% with TEA alone. During initial VS, EEG signals showed right inferior frontal activity as the prominent finding, but during VS with TEA, left inferior frontal activity predominated. ConclusionsIn DMGP, TEA improves gastric dysrhythmia and ameliorates nausea. TEA treatment of nausea provoked by VS resulted in a change of dominance from right to left inferior frontal lobe activity. These data provide new understandings of peripheral and central mechanisms for nausea, and potential future directions for DMGP treatment approaches.

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Effects and probable mechanisms of electroacupuncture at the Zusanli point on upper gastrointestinal motility in rabbits

Abstract: Acupuncture may enhance the gastrointestinal myoelectrical activity of conscious rabbits. The cholinergic nerve, nitric oxide, motilin, and CCK may contribute to acupuncture mechanisms.

Cited by 34 publications

References 14 publications

Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects

Ameliorating effect of transcutaneous electroacupuncture on impaired gastric accommodation induced by cold meal in healthy subjects

Influence of Acupuncture on Leptin, Ghrelin, Insulin and Cholecystokinin in Obese Women: A Randomised, Sham-Controlled Preliminary Trial

Central and Peripheral Effects of Transcutaneous Acupuncture Treatment for Nausea in Patients with Diabetic Gastroparesis

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