Effects and molecular mechanisms of Ninghong black tea extract in nonalcoholic fatty liver disease of rats

Shen, Yu; Xiao, Xiaojuan; Wu, Kunlu; Wang, Yanpeng; Yuan, Yijun; Liu, Jianwei; Sun, Shuming; Liu, Jing

doi:10.1111/1750-3841.14846

Cited by 8 publications

(5 citation statements)

References 50 publications

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“…In the past few years, the widely accepted pathogenesis of NAFLD is the “two‐hit” hypothesis (Buzzetti et al., 2016). The first blow refers to the accumulation of excessive lipids in the cytoplasm of liver cells, which leads to IR and fatty acid metabolism dysfunction (Shen et al., 2020). It will change signal transduction, and triggers a series of toxic events of lipids to cells, such as inflammation, which is the second blow.…”

Section: Introductionmentioning

confidence: 99%

Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro

Zhang

Zhou

et al. 2021

Journal of Food Science

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Nonalcoholic fatty liver disease (NAFLD) is a metabolic syndrome, whose main characteristics are excessive lipid accumulation and oxidative stress. Major royal jelly proteins (MRJPs) is a kind of water‐soluble protein, which is abundant in royal jelly (RJ). The aim of this study was to evaluate the effect of MRJPs on lipid accumulation and oxidative stress of liver cells. Here, we first optimized the conditions for extracting MRJPs from RJ and identified the extraction effect and product by SDS‐PAGE. Then, we used oleic acid (OA) of 1.0 mM to induce hepatocytes for 24 hr to establish a stable cell models of lipid accumulation, and we found that pre‐administration (24 hr) of MRJPs (0.2, 0.5, and 1.0 g/L) could significantly reduce the lipid drop content and triglyceride level in the model cells, and simultaneously reduce the alanine aminotransferase and aspertate aminotransferase levels in the cell culture supernatant. In addition, pre‐incubation (24 hr) with MRJPs (0.2, 0.5, and 1.0 g/L) could restore superoxide dismutase (SOD) level and mitochondrial membrane potential as compared with OA group. Furthermore, MRJPs administration significantly upregulated the expression of Silent Information Regulator 2 Associated Protein 3, mitochondrial superoxide dismutase (SOD2), and cytochrome c oxidase subunit IV in OA‐treated HepG2 cells. The study for the first time provides evidences on the lipid‐lowering effect of MRJPs at the cellular level, which can further provide support for the development and application of polypeptide drugs in the future, and can also provide a choice for the prevention and treatment of liver metabolic diseases represented by NAFLD. Practical Application Our study proved that MRJPs had substantial preventing effect on OA‐induced lipid accumulation and mitochondrial dysfunction in HepG2 cells. This research can further provide theoretical support for the development and application of peptide drugs in the future. Besides, it can not only further broaden our understanding of NAFLD and other diseases, but also provide ideas for research on oxidative stress and lipid accumulation in the body.

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Section: Introductionmentioning

confidence: 99%

Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro

Zhang

Zhou

et al. 2021

Journal of Food Science

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“…More importantly, polyphenols from raw bowl tea were beneficial to alleviating NAFLD in C57BL/6N mice by regulating the abundance of gut microbiota, such as decreasing the level of Firmicutes and increasing the levels of Bacteroides and Akkermansia [111]. Besides, the extract of Ning Hong black tea decreased the number of hepatic lipid droplets in SD rats by upregulating the expression of PPAR-α and microsomal triglyceride transfer protein, as well as promoting fatty acid βoxidation [115]. In short, green, black, and dark teas, as well as tea polyphenols, could alleviate NAFLD through improving liver function, regulating glucose and lipid metabolism, decreasing the levels of ROS and inflammatory cytokines, and modulating the composition of gut microbiota (Table 1), with decreasing the expression of miR-34a, increasing the expression of miR-194, and upregulating SIRT1, PPAR-α, and AMPK signaling pathways (Figure 2).…”

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confidence: 98%

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Gan

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Fatty liver disease (FLD), including nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), is a serious chronic metabolic disease that affects a wide range of people. Lipid accumulation accompanied by oxidative stress and inflammation in the liver is the most important pathogenesis of FLD. The plant-based, high-fiber, and low-fat diet has been recommended to manage FLD for a long time. This review discusses the current state of the art into the effects, mechanisms, and clinical application of plant-based foods in NAFLD and AFLD, with highlighting related molecular mechanisms. Epidemiological evidence revealed that the consumption of several plant-based foods was beneficial to alleviating FLD. Further experimental studies found out that fruits, spices, teas, coffee, and other plants, as well as their bioactive compounds, such as resveratrol, anthocyanin, curcumin, and tea polyphenols, could alleviate FLD by ameliorating hepatic steatosis, oxidative stress, inflammation, gut dysbiosis, and apoptosis, as well as regulating autophagy and ethanol metabolism. More importantly, clinical trials confirmed the beneficial effects of plant-based foods on patients with fatty liver. However, several issues need to be further studied especially the safety and effective doses of plant-based foods and their bioactive compounds. Overall, certain plant-based foods are promising natural sources of bioactive compounds to prevent and alleviate fatty liver disease.

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“…48 Ninghong black tea extract could alleviate HFD-induced NAFLD by promoting the expression of peroxisome proliferator-activated receptor α (PPARα) and microsomal triglyceride transfer protein (MTP) in liver tissue, thereby promoting fatty acid β-oxidation and very low-density lipoprotein synthesis. 49 Pu-erh tea showed a significant effect on the prevention and treatment of NAFLD, which markedly reduced inflammatory cell infiltration and fibrosis in fat cells. 50 Meanwhile, Pu-erh tea promoted the conversion of glucose in the blood into fat to lower blood sugar.…”

Section: Intervention Of Nafld Through Tea Drinkingmentioning

confidence: 96%

“…Heukcha (HCE) is a natural postfermentation green tea extract, which can inhibit high cholesterol diet-induced liver oxidative stress, lipid accumulation and fibrosis, and suppress hypercholesterolemia by increasing the expression of CYP7A1 disease and the occurrence of NAFLD . Ninghong black tea extract could alleviate HFD-induced NAFLD by promoting the expression of peroxisome proliferator-activated receptor α (PPARα) and microsomal triglyceride transfer protein (MTP) in liver tissue, thereby promoting fatty acid β-oxidation and very low-density lipoprotein synthesis . Pu-erh tea showed a significant effect on the prevention and treatment of NAFLD, which markedly reduced inflammatory cell infiltration and fibrosis in fat cells .…”

Section: Prevention Intervention and Treatment Strategies For Nafldmentioning

confidence: 99%

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

Yang

Huang

et al. 2023

J. Agric. Food Chem.

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Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, is a multifactorial disease resulting from the interaction between environment, genetic background, and metabolic stress. Most treatments for NAFLD include dietary intervention and exercise show limited efficacy due to the complex mechanisms involved in NAFLD. Meanwhile, drug therapy is accompanied by serious side effects. The development of high-efficiency natural supplements is a sustainable strategy for the prevention and treatment of NAFLD. As the second most consumed beverage, tea has health benefits that have been widely recognized. Nevertheless, the intervention of tea active compounds in NAFLD has received limited attention. Tea contains abundant bioactive compounds with potential effects on NAFLD, such as catechins, flavonoids, theanine, tea pigments, and tea polysaccharides. We reviewed the intrinsic and environmental factors and pathogenic mechanisms that affect the occurrence and development of NAFLD, and summarized the influences of exercise, drugs, diet, and tea drinking on NAFLD. On this basis, we further analyzed the potential effects and molecular regulatory mechanisms of tea active compounds on NAFLD and proposed future development directions. This review hopes to provide novel insights into the development and application of tea active compounds in the prevention and treatment of NAFLD.

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Effects and molecular mechanisms of Ninghong black tea extract in nonalcoholic fatty liver disease of rats

Cited by 8 publications

References 50 publications

Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro

Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

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