Effects and Mechanisms of Transcutaneous Electrical Acustimulation on Postoperative Recovery After Elective Cesarean Section

Li, Miaomiao; Xu, Feng; Liu, Minjie; Li, Yinfang; Zheng, Jingfei; Zhu, Ying; Lin, Lin; Chen, Jiande

doi:10.1111/ner.13178

Cited by 12 publications

(8 citation statements)

References 39 publications

(107 reference statements)

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“…These findings seemed to suggest that the iVNS-induced acceleration in postoperative recovery was attributed to the enhancement of vagal activity. This was in agreement with several previous studies in which electrical stimulation performed noninvasively via acupuncture points was reported to enhance vagal activity and the enhanced vagal activity was associated with accelerated postoperative recovery ( Li et al, 2020 ; Zhu et al, 2020 ; Zhang et al, 2021 ).…”

Section: Discussionsupporting

confidence: 93%

Acceleration of postoperative recovery with brief intraoperative vagal nerve stimulation mediated via the autonomic mechanism

2023

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IntroductionPostoperative recovery is largely dependent on the restoration of gastrointestinal motility. The aim of this study was to investigate the effects and mechanisms of intraoperative vagus nerve stimulation (iVNS) on postoperative recovery from abdominal surgery in rats.MethodsThe Nissen fundoplication surgery was performed on two groups of rats: sham-iVNS group and iVNS group (VNS was performed during surgery). Animal’s behavior, eating, drinking and feces’ conditions were monitored at specific postoperative days. Gastric slow waves (GSWs) and electrocardiogram (ECG) were recorded; blood samples were collected for the assessment of inflammatory cytokines.Results(1) iVNS shortened initiate times to water and food intake (p = 0.004) and increased the number of fecal pellets (p < 0.05, vs. sham-iVNS) and the percentage of water content in fecal pellets (p < 0.05). (2) iVNS improved gastric pace-making activity at 6 h after surgery reflected as a higher percentage of normal slow waves (p = 0.015, vs. sham-iVNS). (3) iVNS suppressed inflammatory cytokines at 24 h after surgery compared to sham-iVNS (TNF-α: p = 0.001; IL-1β: p = 0.037; IL-6: p = 0.002). (4) iVNS increased vagal tone compared to sham-iVNS group at 6 h and 24 h after the surgery (p < 0.05). Increased vagal tone was correlated with a faster postoperative recovery to start water and food intake.ConclusionBrief iVNS accelerates postoperative recovery by ameliorating postoperative animal behaviors, improving gastrointestinal motility and inhibiting inflammatory cytokines mediated via the enhanced vagal tone.

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Section: Discussionsupporting

confidence: 93%

Acceleration of postoperative recovery with brief intraoperative vagal nerve stimulation mediated via the autonomic mechanism

2023

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“…A total of 9 studies ( n = 1,196) were included in the intraoperative consumption of sedatives [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and noradrenaline (NE)] at 24, 48, and 72 h after surgery ( 7 , 41 , 49 , 50 , 53 , 55–58 ). TNF-α was lower in the TEAS group at 48 h postoperatively (WMD: −15.91 pg./mL, 99% CI: −27.89 to −3.93).…”

Section: Resultsmentioning

confidence: 99%

Effects of transcutaneous electrical acupoint stimulation on early postoperative pain and recovery: a comprehensive systematic review and meta-analysis of randomized controlled trials

Tan,

Jiang,

et al. 2024

Front. Med.

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BackgroundPrevious studies have indicated beneficial outcomes of transcutaneous electrical acupoint stimulation (TEAS), but high-quality and comprehensive meta-analyses are lacking. The aim was to quantitatively analyze the efficacy and safety of perioperative TEAS on postoperative pain and recovery.MethodsPubMed, Web of Science, EMBASE, and the Cochrane Library were searched through July 2022. Randomized controlled trials (RCTs) that examined the perioperative application of TEAS in adults compared with sham-TEAS and/or non-TEAS were eligible. Cumulative analgesic consumption within 24 h and rest pain scores at 2, 6, 12, and 24 h postoperatively were the two co-primary outcomes.ResultsSeventy-six RCTs (n = 9,665 patients) were included. Patients treated with TEAS experienced a reduction in clinical importance in cumulative analgesic (morphine equivalent) consumption (WMD: −14.60 mg, 97.5% CI: −23.60 to −5.60; p < 0.001) and a reduction in statistical importance in rest pain scores at multiple time points within the first 24 postoperative hours. The secondary outcome analysis also identified clinically significant recovery benefits to TEAS during the first 24 h after surgery. Furthermore, TEAS could effectively reduce opioid-related side effects and did not increase serious side effects.ConclusionThis article describes current evidence about TEAS intervention on early postoperative pain and recovery. The results support the effectiveness of TEAS, but more high-quality evidence of clinical applicability is also needed.Systematic review registrationPROSPERO (CRD42021249814).

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“…A large number of studies have shown that EGEG has good diagnostic role in gastrointestinal diseases such as gastritis, gastric ulcer, tachycardia/bradycardia, etc. It also has some diagnostic significance for functional dyspepsia with obesity, motion sickness, post-surgical gastrointestinal dysfunction [ 16 – 18 ]. Although worldwide researchers have figured out certain rules for the clinical research of electrogastrogram, some criteria have been developed for the auxiliary diagnosis of diseases, such as low amplitude (< 150µV) for gastritis, high amplitude (> 250µV) and high frequency (> 3.5CPM) for gastric ulcer.…”

Section: Discussionmentioning

confidence: 99%

Potential value of gastrointestinal myoelectrical activity in the diagnosis of anxiety-depression disorder: a population-based study

Li,

Peng,

Yang

et al. 2023

BMC Psychiatry

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Background Depression and anxiety are frequently coexisted mental illness. The lack of solid objective diagnostic criteria has led to a high rate of suicide. The brain-gut axis bridges the gastrointestinal system with neuropsychiatric disorders. However, it is still not possible to reflect mental disease with gastrointestinal information. The study aimed to explore the auxiliary diagnostic value of gastrointestinal myoelectrical activity in anxiety-depression disorders (ADD) without gastrointestinal disturbance. Methods A natural population cohort from 3 districts in Western China were established. The Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7 were used to assess ADD. Gastrointestinal myoelectrical activity of ADD were measured by multi-channel cutaneous electrogastroenterogram (EGEG). Then the parameters of EGEG between ADD and healthy controls were analyzed. Results The average amplitude and response area of intestinal channel in ADD were significantly lower than those of controls (153.49 ± 78.69 vs. 179.83 ± 103.90, 57.27 ± 29.05 vs. 67.70 ± 38.32), which were shown to be protective factors for ADD (OR = 0.944 and 0.844, respectively). Further, the scale item scores related to the core symptoms of anxiety and depression were also associated with these two channels (p < 0.05), and the gastrointestinal electrical signals of ADD are significantly changed in the elderly compared to the young adults. Conclusions The intestinal myoelectrical activity has a certain auxiliary diagnostic value in psychiatric disorders and is expected to provide objective reference for the diagnosis of anxiety and depression.

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Effects and Mechanisms of Transcutaneous Electrical Acustimulation on Postoperative Recovery After Elective Cesarean Section

Cited by 12 publications

References 39 publications

Acceleration of postoperative recovery with brief intraoperative vagal nerve stimulation mediated via the autonomic mechanism

Acceleration of postoperative recovery with brief intraoperative vagal nerve stimulation mediated via the autonomic mechanism

Effects of transcutaneous electrical acupoint stimulation on early postoperative pain and recovery: a comprehensive systematic review and meta-analysis of randomized controlled trials

Potential value of gastrointestinal myoelectrical activity in the diagnosis of anxiety-depression disorder: a population-based study

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