Effects and mechanisms of traditional Chinese medicines on functional dyspepsia: A review

Liu, Bo; Kou, Zixiang; Chen, Baogui

doi:10.1016/j.chmed.2023.06.001

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…The net weight of the stomach was measured and recorded. The gastric emptying rate was calculated according to the following equation (Liu et al, 2023a):…”

Section: Measurement Of the Gastrointestinal Motility Indexmentioning

confidence: 99%

The effects of Massa Medicata Fermentata on the digestive function and intestinal flora of mice with functional dyspepsia

Wang,

Li,

Yang

et al. 2024

Front. Pharmacol.

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Introduction: The purpose of this study was to identify the chemical components of Massa Medicata Fermentata (MMF) in different fermentation methods, analyze its regulatory effects on gastrointestinal propulsion and intestinal flora in mice with food accumulation, and further explore its mechanism of action in the treatment of dyspepsia.Methods: The chemical compositions of three kinds of MMF were identified using the UPLC-Q- Exactive Orbitrap mass spectrometer. A model of spleen deficiency and food accumulation in mice was established. The gastric emptying rate and intestinal propulsion rate were calculated, serum gastrin concentration and cholinesterase activity were measured, and 16S rRNA microbial detection was performed in different groups of mouse feces.Results: The results showed that a total of 95 chemical components were identified from the three MMF extracts, 62 of which were the same, but there were differences in flavonoids and their glycosides, organic acids, and esters. MMF, PFMMF, and commercial MMF could all significantly improve the gastric emptying rate, intestinal propulsion rate, and GAS concentration in the serum of model mice; PFMMF has a better effect, while there was no significant difference in cholinesterase activity among the groups (p > 0.05). The 16S rRNA sequencing results showed that the MMF and PFMMF could increase the content of beneficial bacteria Bacteroidetes and decrease the pathogenic bacteria Verrucomicrobia in the intestines of model mice, while the commercial MMF could not.Discussion: Studies suggest that MMF has a variety of possible mechanisms for improving food accumulation and treating gastrointestinal dyspepsia, which provides reference value for the quality evaluation and clinical application of MMF.

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“…The net weight of the stomach was measured and recorded. The gastric emptying rate was calculated according to the following equation (Liu et al, 2023a):…”

Section: Measurement Of the Gastrointestinal Motility Indexmentioning

confidence: 99%

The effects of Massa Medicata Fermentata on the digestive function and intestinal flora of mice with functional dyspepsia

Wang,

Li,

Yang

et al. 2024

Front. Pharmacol.

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“…Chinese herbal medicine (CHM) has been used as an alternative treatment in the Asia-Pacific region for thousands of years. Previous studies suggested that CHM treatment has great potential and safety in alleviating the symptoms of FD [20][21][22][23]. In particular, Zhishixiaopi decoction (ZSXP) is a Chinese herbal medicine prescription from "Lanshi Micang" (Jin Dynasty.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Zhishixiaopi decoction in functional dyspepsia: A meta-analysis of randomized controlled trials

Zhao,

Cheng,

et al. 2024

PLoS ONE

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Background Functional dyspepsia (FD) refers to a group of clinical symptoms caused by gastric and duodenal dysfunction. Which is a chronic functional disorder of the gastrointestinal tract with no cure. Zhishixiaopi decoction (ZSXP) is a type of Chinese herbal prescription that for treating FD. Although some randomized controlled trials (RCTs) report that ZSXP can significantly improve FD clinical symptoms and/or laboratory results, the trial design varies greatly among studies, making it challenging to draw a conclusion of the efficacy of ZSXP in treating FD. Design A systematic review and a meta-analysis. Setting Mianyang Central Hospital. Objective We conducted a systematic review and a meta-analysis to evaluate the efficacy and safety of ZSXP for treating FD. Methods We developed inclusion and exclusion criteria based on FD diagnosed criteria, interventions to treat FD, and outcomes of these interventions. Search strategies combined disease terms, symptom terms, anatomy terms and intervention terms. Literature search was conducted on eight online databases in English or Chinese, including Medline (via PubMed), Embase (via Ovid), The Cochrane Library, Web of Science, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), and Wanfang Database. Intervention The experimental group received oral administration of ZSXP and had a complete treatment process. ZSXP needs to fully contain the key herbal ingredients, regardless of whether the dosage of each herb is consistent with the original prescription. The Control group received monotherapy or combination therapy of other Western medicine and had a complete treatment process. Outcomes The primary outcomes appraised were Total effective rate (TER), serum levels of Motilin(MOT), Gastrin(GAS) and Somatostatin (SS), Gastric emptying rate (GER) using a Barium meal method (GER(B)) and Gastric half emptying time using an Ultrasonic method (GHET(T1/2)). The Cochrane Bias Risk Tool was used for quality critical appraisal, Review Manager (RevMan) version 5.3 was used for statistical analysis. Results A total of 21 medium-quality RCTs were included in the meta-analysis. All 21 included studies were conducted and completed in Mainland China from 1998 to 2020. The treatment duration was between two weeks to two months. The meta-analysis suggests that, compared with the Western medicine treatment group, ZSXP treatment was more effective to improving the TER in FD [Odds ratio, OR = 3.54, 95%CI:(2.49, 5.05), Z = 6.99, P<0.00001] without significant increase in adverse events. However, no statistical significance was found between the groups in serum MOT levels [Standard mean difference, SMD = 1.05, 95%CI:(-0.42, 2.53), Z = 1.04, P = 0.16], serum GAS levels [SMD = -0.16, 95%CI:(-1.20, 0.88), Z = 0.31, P = 0.76], serum SS levels [SMD = -0.04, 95%CI:(-1.97, 1.89), Z = 0.04, P = 0.97], GER(B) [SMD = 1.09, 95%CI:(-0.81, 3.00), Z = 1.12, P = 0.26]or GHET(T1/2) [Mean difference, MD = -2.18, 95%CI:(-5.55, 1.19), Z = 1.27, P = 0.20]. Conclusions The meta-analysis suggests that Zhishixiaopi treatment is a relatively effective and safe traditional Chinese medicine prescription and could be used for functional dyspepsia treatment. Considering the limitations of this study, the conclusion needs to be further confirmed by high-quality, multi-center, and large-sample randomized controlled trials.

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Uncovering the material basis and mechanism of Jianwei Xiaoshi tablet against functional dyspepsia using ultra‐high‐performance liquid chromatography‐mass spectrometry and network pharmacology

Cheng,

Zhang,

Huang

et al. 2024

Biomedical Chromatography

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Functional dyspepsia (FD) is a common digestive disease. Jianwei Xiaoshi (JWXS) tablet is composed of Radix Pseudostellariae (TZS), Pericarpium Citri Reticulatae (CP), Rhizoma Dioscoreae (SY), fired Hordei Fructus Germinatus (CMY) and Crataegi Fructus (SZ). It is a commonly used drug in the treatment of FD in China and has good therapeutic effects. However, there is very little research about the substance basis and action mechanism of JWXS tablet. In this research, ultra‐high‐performance liquid chromatography‐mass spectrometry (UPLC‐MS) and network pharmacology were used to explore the substance basis and action mechanism of the JWXS tablet. Finally, 19, 79, 22, 22 and 39 constituents were identified in the extracts of TZS, CP, SY, CMY and SZ, respectively. Based on these findings, a total of 104 ingredients were identified in JWXS tablet and 29 potentially absorbed ingredients were detected in rat plasma. The results of network pharmacology indicated that the inhibition of gastric acid secretion, the regulation of gastrointestinal motility, inflammation and immune response were the key approaches for treating FD with JWXS tablet. The material basis and potential action mechanism of JWXS tablet in treating FD were comprehensively clarified for the first time. This study will improve our understanding of JWXS tablet.

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Effects and mechanisms of traditional Chinese medicines on functional dyspepsia: A review

Cited by 5 publications

References 34 publications

The effects of Massa Medicata Fermentata on the digestive function and intestinal flora of mice with functional dyspepsia

The effects of Massa Medicata Fermentata on the digestive function and intestinal flora of mice with functional dyspepsia

Efficacy and safety of Zhishixiaopi decoction in functional dyspepsia: A meta-analysis of randomized controlled trials

Uncovering the material basis and mechanism of Jianwei Xiaoshi tablet against functional dyspepsia using ultra‐high‐performance liquid chromatography‐mass spectrometry and network pharmacology

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