Effects and Mechanisms of Taohong Siwu Decoction on the Prevention and Treatment of Myocardial Injury

Cui, Guo-Hong; Guo, Hai-dong

doi:10.3389/fphar.2022.816347

Cited by 18 publications

(12 citation statements)

References 71 publications

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“…These mechanisms make it a potential treatment option for preventing and treating myocardial injury. [54] Given its positive therapeutic effect on atherosclerosis and the interrelation between atherosclerosis and DVT, investigating whether THSWD can simultaneously inhibit The PI3K/Akt signaling pathway plays a critical role in numerous physiological and pathological processes, including cell growth, differentiation, and proliferation. [55] Research has shown that the FXII protein can promote the occurrence of deep vein thrombosis (DVT) by inducing an inflammatory response and activating the PI3K/AKT signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Exploring the potential mechanism and molecular targets of Taohong Siwu Decoction against deep vein thrombosis based on network pharmacology and analysis docking

Fan,

Liu,

Liu

2024

Medicine

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This study aims to investigate the mechanism of Taohong Siwu Decoction (THSWD) against deep vein thrombosis (DVT) using network pharmacology and molecular docking technology. We used the Traditional Chinese Medicine Systems Pharmacology database and reviewed literature to identify the main chemical components of THSWD. To find targets for DVT, we consulted GeneCards, Therapeutic Target Database, and PharmGKB databases. We used Cytoscape 3.8.2 software to construct herb-disease-gene-target networks. Additionally, we integrated drug targets and disease targets on the STRING platform to create a protein–protein interaction network. Then, we conducted Kyoto Encyclopedia of Genes and Genomes and gene ontology analysis. Finally, We employed the molecular docking method to validate our findings. We identified 56 potential targets associated with DVT and found 61 effective components. beta-sitosterol, quercetin, and kaempferol were the most prominent among these components. Our analysis of the protein–protein interaction network revealed that IL6, L1B, and AKT1 had the highest degree of association. Gene ontology analysis showed that THSWD treatment for DVT may involve response to inorganic substances, negative regulation of cell differentiation, plasma membrane protein complex, positive regulation of phosphorylation, and signaling receptor regulator activity. Kyoto Encyclopedia of Genes and Genomes analysis indicated that lipid and atherosclerosis, pathways in cancer, as well as the PI3K-Akt pathway are the main signal pathways involved. Molecular docking results demonstrated strong binding affinity between beta-sitosterol, quercetin, kaempferol, and AKT1 proteins as well as IL1B and IL6 proteins. The main targets for THSWD treatment of DVT may include AKT1, IL1B, and IL6. Beta-sitosterol, quercetin, and kaempferol may be the active ingredients responsible for producing this effect. These compounds may slow down the progression of DVT by regulating the inflammatory response through the PI3K/Akt pathway.

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Section: Discussionmentioning

confidence: 99%

Exploring the potential mechanism and molecular targets of Taohong Siwu Decoction against deep vein thrombosis based on network pharmacology and analysis docking

Fan,

Liu,

Liu

2024

Medicine

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“…[32,33] THSWD, a well-known Chinese herbal medicine for promoting blood circulation and removing blood stasis, is frequently used in clinical practice to prevent blood stasis in fractures or during the early postoperative period. [34,35] The ingredients Chuanxiong, Angelica, Baishao, Rehmannia glutinosa, Peach kernel, and Safflower in the formula can dilate blood vessels. [36] The primary component of safflower is crocin, which inhibits platelet aggregation and reduces blood coagulation function, ultimately decreasing thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Taohong Siwu decoction in the prevention of deep vein thrombosis in hip surgery patients: A systematic review and meta-analysis of randomized controlled trials

Cai,

Han,

Wang

et al. 2024

Medicine

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Background: This systematic review and meta-analysis aimed to evaluate the effects of Taohong Siwu Decoction (THSWD) combined with low molecular weight heparin (LMWH), as well as THSWD alone, on the incidence of Deep vein thrombosis (DVT), D-dimer levels, prothrombin time (PT), activated partial thromboplastin time (APTT), visual analogue scale (VAS) pain score, and calf swelling in patients undergoing hip fracture or replacement surgery, compared to LMWH. Methods: According to the predefined inclusion criteria, we conducted a comprehensive search for randomized controlled trials (RCTs) examining the efficacy of THSWD combined with LMWH or THSWD compared to LMWH in patients with hip fractures or undergoing replacement surgery. The search was performed across multiple databases including China National Knowledge Internet, WanFang, Sinomed, Duxiu, PubMed, Embase, Google Scholar, Cochrane, and Web of Science from their inception until December 2023. Additionally, relevant literature references were retrieved and hand searching of pertinent journals was conducted. The methodological quality assessment of the included trials was carried out following the guidelines outlined in the Cochrane Handbook. Review Manager 5.4 was applied in analyzing and synthesizing. Results: A total of 18 RCTs with 1353 patients were included. The results of meta-analysis showed that compared with the control group, the combined group had a better effect on the incidence of DVT [RR = 0.32, 95% CI(0.17, 0.58; P = .0002], D-dimer [SMD = −5.88, 95% CI(−7.66, −4.11); P < .00001], VAS [MD = −1.16, 95% CI(−1.81, −0.50); P = .0005], Calf circumference difference [MD = −0.56, 95% CI(−1.05, −0.08); P = .02]. There was no significant difference in PT and APTT between the combined group and the control group. Meta-analysis results show that the D-dimer, incidence of DVT, PT, and APTT did not significantly differ between the THSWD and the LMWH groups. Conclusion: This meta-analysis shows that compared with LMWH, THSWD combined with LMWH has a better efficacy in the treatment of DVT after hip surgery, without a significant increase in the incidence of adverse events. Additionally, the combined therapy can also reduce D-dimer, VAS, and swelling. However, due to the limitations of the included studies (such as small sample size and low-quality evidence), the results need to be further verified in more rigorous multicenter clinical trials with a large sample size.

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“…It also has anti‐platelet aggregation effects and protects the vascular endothelium 20 . Recent studies used Gualou Xiebai Banxia Decoction to treat 31 cases of chronic heart failure of coronary heart disease with phlegm rubidium‐blocked qi stagnation and blood stasis, with satisfactory clinical efficacy and a total effective rate of 90.3% 21 . Another study treated 226 patients with stable angina pectoris and type‐2 diabetes by trichosanthis peel injection and found that angina pectoris symptoms and hemorheology indices in the experimental group were significantly improved 21 .…”

Section: Discussionmentioning

confidence: 99%

“…20 Recent studies used Gualou Xiebai Banxia Decoction to treat 31 cases of chronic heart failure of coronary heart disease with phlegm rubidium-blocked qi stagnation and blood stasis, with satisfactory clinical efficacy and a total effective rate of 90.3%. 21 Another study treated 226 patients with stable angina pectoris and type-2 diabetes by trichosanthis peel injection and found that angina pectoris symptoms and hemorheology indices in the experimental group were significantly improved. 21 Moreover, the protective effect of trichosanthis peel was found on acute myocardial ischemia in rats, and decoction of trichosanthis peel had a significant protective effect on acute myocardial ischemia in rats, while its mechanism may be related to enhancing the ability to scavenge free radicals.…”

Section: Discussionmentioning

confidence: 99%

“…21 Another study treated 226 patients with stable angina pectoris and type-2 diabetes by trichosanthis peel injection and found that angina pectoris symptoms and hemorheology indices in the experimental group were significantly improved. 21 Moreover, the protective effect of trichosanthis peel was found on acute myocardial ischemia in rats, and decoction of trichosanthis peel had a significant protective effect on acute myocardial ischemia in rats, while its mechanism may be related to enhancing the ability to scavenge free radicals. 22 Studies have found that after water extraction and alcohol precipitation of trichosanthis peel, the isolated substance has the effect of inhibiting ACE activity and anti-renin, which is speculated to protect the cardiovascular system.…”

Section: Discussionmentioning

confidence: 99%

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Study on the mechanism underlying Trichosanthis peel injection‐induced improvements in myocardial fibrosis markers in patients with chronic heart failure

He,

Gu,

Yang

et al. 2024

Clin Exp Pharma Physio

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In this research, we aimed to observe the changes in myocardial fibrosis indices in patients with chronic heart failure before and after treatment and to evaluate the anti‐chronic heart failure and ventricular remodelling effects of Trichosanthis peel (TP) injection. This study was a single‐center, open, single‐blind, randomized controlled study with an optimal efficacy design. Patients were consecutively and randomly divided into two groups, with 36 patients in the TP injection group and 36 patients in the conventional treatment group. ELISA was used to measure changes in myocardial fibrosis indices before and after discharge, including transforming growth factor β (TGF‐β), serum hyaluronic acid (HA), type I procollagen (PCI), laminin (LN) and type III procollagen (PCIII). There was no significant difference between the two groups in clinical data or baseline level of myocardial fibrosis before treatment. After treatment, compared with the conventional treatment group, the myocardial fibrosis index was significantly decreased following TP injection. Our findings indicate that TP injection combined with conventional medicine can attenuate myocardial fibrosis by reducing angiotensin II, aldosterone, TGFβ, HA, PCI, metallomatrix proteinase 2, connective tissue growth factor and LN and promote ventricular remodelling in patients with chronic heart failure.

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Effects and Mechanisms of Taohong Siwu Decoction on the Prevention and Treatment of Myocardial Injury

Cited by 18 publications

References 71 publications

Exploring the potential mechanism and molecular targets of Taohong Siwu Decoction against deep vein thrombosis based on network pharmacology and analysis docking

Exploring the potential mechanism and molecular targets of Taohong Siwu Decoction against deep vein thrombosis based on network pharmacology and analysis docking

Effectiveness of Taohong Siwu decoction in the prevention of deep vein thrombosis in hip surgery patients: A systematic review and meta-analysis of randomized controlled trials

Study on the mechanism underlying Trichosanthis peel injection‐induced improvements in myocardial fibrosis markers in patients with chronic heart failure

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