Effectiveness, Safety and Tolerance of Methotrexate in Vietnamese Psoriatic Arthritis Patients

Abstract

AIM:To access the effectiveness, safety and tolerance of methotrexate (MTX) in psoriatic arthritis (PsA) treatment.METHODS:We recruit 37 patients, admitted at HCMC Hospital of Dermato-Venereology from 1/2016 to 3/2017, with MTX dosage ranging from 10 mg to 15 mg per week.RESULTS:Skin lesion response after 12 weeks improved PASI 50: 40.5%, PASI 75: 24.3%. Disease activity score decreased after 12 weeks with ∆DAS28 = -1.43 + 0.79, 37.8% PsA achieved complete remission. Nausea and vomiting were 8.1%. These symptoms were mild and transient. We did not stop MTX usage. The rate of elevating SGPT 2-3 times as much as the upper limit of the normal range was 2.7%.CONCLUSION:We finally demonstrated that the rate of treatment response in Vietnam is the same as demonstrated by foreign authors in other countries.

Protective Effect of Linoleic Acid on Liver Toxicity Induced By Methotrexate

“…While it is used as an antineoplastic in high doses, it is used as an immunosuppressive and anti-inflammatory in low doses (Martin et al, 2009). There are many studies in the literature about pure squamous cell cancer of the urinary tract (Griffiths et al, 2019), in cancer types (Wippel et al, 2019), romatoid artrit (Boone et al, 2019), in dermatology (Thi et al, 2019), where methotrexate is used. MTX creates side effects, especially nephrotoxicity and hepatotoxicity, against these wide indications for use.…”