Effectiveness of water as the neutralising agent for glycolic acid peels in skin phototypes IV‐V

Abstract

The aim of the study is to evaluate the effectiveness of water as a substitute for sodium bicarbonate plus solution in the neutralisation process of chemical peeling using a 35% glycolic acid solution. This randomised, double-blind, split-face, controlled trial was conducted in an outpatient setting. A total of 126 healthy patients with skin phototypes IV-V aged between 18 and 60 years old were recruited. Chemical peeling was performed with 35% glycolic acid solution. One side of the face was neutralised with water, and the other side of the face was neutralised with a sodium bicarbonate plus solution. The main outcome of this study was measured by the degree of erythema, pruritus and pain scores. Significant difference in the pain score immediately after the neutralisation process of the chemical peeling with glycolic acid was seen. However, there were no significant differences in the degree of erythema or the pruritus score. These results indicate that water can be used as a substitute for sodium bicarbonate plus solution in the neutralisation process of chemical peeling with 35% glycolic acid in patients with skin phototypes IV-V.

Chemical peeling with 35% glycolic acid for the treatment of disseminated facial verruca plana: A randomized, split‐face, evaluator‐blinded trial

“…Therefore, we speculated that the efficacy of adapalene application in disseminated facial verruca plana is limited; however, its specific effects require further investigation. Third, the Fitzpatrick skin types of patients enrolled in our study were types III and IV, and previous studies supported the claim that the application of 35% GA is safe among patients with this skin type 19 . In future studies, the GA concentration for chemical peels may need to be adjusted for patients with different Fitzpatrick skin types.…”

“…Third, the Fitzpatrick skin types of patients enrolled in our study were types III and IV, and previous studies supported the claim that the application of 35% GA is safe among patients with this skin type. 19 In future studies, the GA concentration for chemical peels may need to be adjusted for patients with different Fitzpatrick skin types.…”

Adjuvant therapies of acne: review of literatures

“…A recent randomized split face study found water can potentially use as a substitute for sodium bicarbonate plus solution in the neutralisation of 35% glycolic acid solution. 27 Various clinical trials have shown the effectiveness of other chemical peelings, such as Jessner peel, lactic acid, pyruvic acid, trichloroacetic acid (TCA), amino fruit acid (AFA), pyruvic acid, and mandelic acid. Jessner peel contains 14% resorcinol, 14% SA, 14% lactic acid, and 95% ethanol 95 which acts as keratolytic, antibacterial, and antiinflammatory agent.…”