Effectiveness of Vitamin D Therapy in Orthopaedic Trauma Patients

Robertson, D.S.; Jenkins, Tyler J.; Murtha, Yvonne M.; Rocca, Gregory J. Della; Volgas, David A.; Stannard, James P.; Crist, Brett D.

doi:10.1097/bot.0000000000000366

Cited by 18 publications

(19 citation statements)

References 11 publications

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“…Robertson et al conducted study on 201 adult trauma patient with vitamin D deficiency. After supplementation 80% of them improved [24] . 60 deficient patients were randomized in two groups and one group was given weekly followed by daily dosing, while other was given only daily regime.…”

Section: Discussionmentioning

confidence: 97%

To compare effect of daily and weekly vitamin D in adult trauma patients with vitamin D deficiency

Jain¹,

Mathur²,

Faujdar³

et al. 2019

Int. J. Orthop. Sci.

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Background: Daily and weekly vitamin D dose are frequently used in treatment of vitamin D deficiency. This study analyses their individual roles in the management of vitamin D deficiency. And also to know significance of Singh index in adult trauma patient. Material & Method: A Randomized Comparative Study was conducted in the Department of Orthopedics, Mahatma Gandhi Hospital, Jaipur from January, 2017 to June, 2018 on a sample size of 60 patients diagnosed with vitamin D deficiency. Singh index was calculated in all patients enrolled in the study. Results: On Comparing effect of daily and weekly dosing in vitamin D deficient patient, weekly dose was more effective at short term i.e. 3 months but both were equally effective after 9 months. There was no significant association between Singh index and vitamin D deficiency in adult trauma patients. Conclusion: Given the potential of vitamin D in fracture healing, the clinicians treating adult fracture patients should be aware of the frequent presence of vitamin D deficiency. Regular supplement of vitamin D therapy provided a favorable outcome in the trauma patients. Weekly and daily dosing are both effective to correct vitamin D deficiency but with weekly doses normal levels are achieved earlier.

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Section: Discussionmentioning

confidence: 97%

To compare effect of daily and weekly vitamin D in adult trauma patients with vitamin D deficiency

Jain¹,

Mathur²,

Faujdar³

et al. 2019

Int. J. Orthop. Sci.

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“…population. [23][24][25] Naturally, the increase in serum levels is dependent on patient adherence, which also seems to vary between populations. Andres et al reported 82% of their adult fracture patients were adherent to a daily 1,600 IU vitamin D dose; 25 this is much higher than the 33% of participants that reported taking their supplement daily in our trial.…”

Section: Discussionmentioning

confidence: 99%

Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2): The Clinical Outcomes of a Multicenter 2 × 2 Factorial Randomized Controlled Pilot Trial in Young Femoral Neck Fracture Patients

Slobogean

Sprague

Bzovsky

et al. 2020

Journal of Orthopaedic Trauma

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Objective: To assess whether fixation method and vitamin D supplementation impact the risk of patient important outcomes within 12 months of injury in non-geriatric femoral neck fracture patients. Design: Pilot factorial randomized controlled trial. Setting: 15 North American clinical sites. Participants: 91 adults aged 18-60 years with a femoral neck fracture requiring surgical fixation. Intervention: Participants were randomized to a surgical intervention (sliding hip screw or cancellous screws) and a vitamin D intervention (vitamin D 3 4,000 IU daily versus placebo for 6 months). Main Outcome Measurements: The primary clinical outcome was a composite of patient important complications (re-operation, femoral head osteonecrosis, severe femoral neck malunion, nonunion). Secondary outcomes included fracture healing complications and radiographic fracture healing.

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“…1,2 It is estimated that 65% of Canadians and 77% of Americans have hypovitaminosis D. 3,4 Previous fracture care research has focused on vitamin D levels in elderly populations 5,6 ; however, recent research has found that more than two-thirds of nongeriatric fracture patients may have serum vitamin D levels that are too low to maintain adequate bone health. [7][8][9][10][11] Although it is well established that vitamin D plays an important role in bone metabolism, its role in acute fracture healing is less clear. Experimental studies in animals [12][13][14][15][16] have suggested that vitamin D may have a positive impact on fracture healing; however, a systematic review of fracture healing in humans concluded that the influence of vitamin D deficiency on fracture outcomes is unknown and there is limited evidence available to guide practice.…”

Section: Introductionmentioning

confidence: 99%

Prescription of Vitamin D to Fracture Patients

Sprague

Bhandari

Devji

et al. 2016

Journal of Orthopaedic Trauma

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Effectiveness of Vitamin D Therapy in Orthopaedic Trauma Patients

Abstract: Vitamin D therapy improved the majority of the patients' vitamin D-25-OH level but did not normalize most. Patients with initial deficiency had the largest improvement. This study indicates that vigilance is required to adequately treat a low serum vitamin D-25-OH level.

Cited by 18 publications

References 11 publications

To compare effect of daily and weekly vitamin D in adult trauma patients with vitamin D deficiency

To compare effect of daily and weekly vitamin D in adult trauma patients with vitamin D deficiency

Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2): The Clinical Outcomes of a Multicenter 2 × 2 Factorial Randomized Controlled Pilot Trial in Young Femoral Neck Fracture Patients

Prescription of Vitamin D to Fracture Patients

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