Effectiveness of Vitamin B12 in Treating Recurrent Aphthous Stomatitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Volkov, Ilia; Rudoy, Inna; Freud, Tamar; Sardal, Gabriel; Naimer, Sody; Peleg, Roni; Press, Yan

doi:10.3122/jabfm.2009.01.080113

Cited by 113 publications

(82 citation statements)

References 24 publications

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“…In a randomized, double-blind, placebo-controlled test, a total of 58 patients were studied to determine the effect of 1,000 mcg of sublingual vitamin B 12 on aphthous ulcer outbreaks. 12 The authors found that "the duration of outbreaks, the number of ulcers, and the level of pain were reduced significantly (P>0.05) at 5 and 6 months of treatment." In addition, they found that 74% of the treatment group reached had no ulcers by the end of their 6-month observation period vs. 32% in the control group.…”

Section: Montelukastmentioning

confidence: 99%

Recurrent Aphthous Stomatitis: Diagnosis and Management in Primary Care

Hudson¹

2014

Journal of Patient-Centered Research and Reviews

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Section: Montelukastmentioning

confidence: 99%

Recurrent Aphthous Stomatitis: Diagnosis and Management in Primary Care

Hudson¹

2014

Journal of Patient-Centered Research and Reviews

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“…Ülkemizde yapılan diğer bir çalışmada RAS hastalarının %26,3'ünde vitamin B12, %25,4'ünde ise ferritin düzeyi düşüklüğü saptandığı bildirilmiştir 54 . Bu bilgilere ek olarak, yapılan bir çalışmada RAS hastalarına başlangıç vitamin B12 düzeyi ile bağımsız olarak verilen 1000 mcg vitamin B12'nin RAS rekürrens sıklığı, ülser sayısı ve ağrı şikayetinde belirgin düzelme sağladığı bildirilmiştir 55 . Çalışmamızda RAS ve hematinik eksiklikler arasındaki ilişkinin saptanması için hastaların demir, ferritin, vitamin B12, folik asit, hemoglobin ve hematokrit kan düzeyleri incelendi.…”

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Sociodemographic and clinical characteristics of patients with recurrent aphthous stomatitis

Bahalı¹,

Köktürk²,

Güvenç³

2014

TURKDERM

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Background and Design:The purpose of this study was to obtain data that may provide an insight into the etiopathogenesis of recurrent aphtous stomatitis (RAS) by the way of analysing the sociodemographic and clinical characteristics of patients who had been diagnosed with RAS. Materials and Metods: The patients, who were diagnosed with RAS in the dermatology outpatient clinic, between May 2007 and May 2010, were evaluated retrospectively. The data including sociodemografic and clinical characteristics, and treatment options were recorded. Results: A hundred patients (68 women, 32 men) were included in this study. The average age was 40±13.6 years. RAS was more common in patients with middle-income and low education. The most common type of RAS was minor aphtous ulcers (88%). The lesions were most frequently seen on the lateral side of the tongue (34%) and cheek (34%). Sixty percent of patients had a positive family history. Some factors such as biting (12%), tooth brushing (18%), dental disease presence (82%), food (39%), menstruation (10.3%), stress (76%), iron deficiency (16.7%), vitamin B12 deficiency (22.4%), low serum ferritin levels (18%), and seasonal variability (32%) showed positive correlation with RAS. A negative correlation was found between RAS and smoking. Forty-nine percent of patients had used alternative therapies in addition to drug therapy. The most frequently used alternative method was consumption of sumac (26.5%). Conlucions: In contrast to the literature, our study found that RAS is started in the third decade of life and, approximately 50% of patients prefered alternative treatment methods, particularly sumac. Nowadays, discussions about the etiopathogenesis of RAS continue. In this study, we found that different sociodemographic and clinical factors may be associated with the etiopathogenesis of the disease. Our study will be followed by further studies using prospective design to identify the the etiopathogenesis of RAS. (Turkderm 2014; 48: 242-8)

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“…1 As noted, this study suggests that daily 1000 mcg cyanocobalamin placed under the tongue may be preventive for recurrent aphthous stomatitis (RAS) after 5 months of use. Cyanocobalamin is not bioactive and must first be converted in the body to a bioactive form before it can be of benefit.…”

mentioning

confidence: 99%

“…To the Editor: I appreciated the information in this article, 1 as one who specializes in the diagnosis and treatment of attention deficit/hyperactivity disorder. I am curious whether the drug screen urinalysis performed in this case distinguished between amphetamines and methamphetamine; the article noted the patient's sample was positive for methamphetamine.…”

mentioning

confidence: 99%

Response: Re: Myocardial Infarction Associated with Adderall XR and Alcohol Use in a Young Man

Jiao¹

2009

The Journal of the American Board of Family Medicine

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Effectiveness of Vitamin B12 in Treating Recurrent Aphthous Stomatitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract: Vitamin B(12) treatment, which is simple, inexpensive, and low-risk, seems to be effective for patients suffering from RAS, regardless of the serum vitamin B(12) level.

Cited by 113 publications

References 24 publications

Recurrent Aphthous Stomatitis: Diagnosis and Management in Primary Care

Recurrent Aphthous Stomatitis: Diagnosis and Management in Primary Care

Sociodemographic and clinical characteristics of patients with recurrent aphthous stomatitis

Response: Re: Myocardial Infarction Associated with Adderall XR and Alcohol Use in a Young Man

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