Effectiveness Of Vascular Markers (immunohistochemical Stains) In Soft Tissue Sarcomas

Naeem, Namra; Mushtaq, Sajid; Akhter, Noreen; Hussain, Mudassar; Hassan, Usman

doi:10.29271/jcpsp.2018.05.352

Cited by 9 publications

(9 citation statements)

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“…The tumors from all groups were obtained by CD34 immunohistochemical staining as well as H&E (hematoxylin and eosin) staining to explore the different treatment effects. , As shown in Figure d,e, the cells in group I arranged closely with no vessel damage and necrosis, proving good biocompatibility, low dark toxicity, and low side effects of DAA NPs in vivo . Compared with group II (some serious vessel destruction and slight apoptosis) and group III (minor vessel damage and mild necrosis), the vessel length in group IV was shortest and obviously cell apoptosis or necrosis were observed, indicating the significant cancer ablation of DAA NPs caused by the synergistic antivascular activity of DMXAA and phototherapy of photosensitizer DPP-4.…”

Section: Resultsmentioning

confidence: 99%

Tumor-Microenvironment-Responsive Nanoconjugate for Synergistic Antivascular Activity and Phototherapy

Liang¹,

Huang²,

Wang³

et al. 2018

ACS Nano

131

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Insufficient oxygen supply (hypoxia), short half-life (<40 ns) of singlet oxygen, and up-regulation of the heat shock protein expression in solid tumors impede the photodynamic and photothermal therapeutic efficacy. Herein, a near-infrared carrier-free nanoconjugate directacting antiviral (DAA) with synergistic antivascular activity and pH-responsive photodynamic/photothermal behavior was designed and synthesized to improve cancer treatment efficacy. Obtained by the self-assembly approach, the biocompatible DAA nanoparticles (NPs) displayed amplifying pH-responsive photodynamic/photothermal performance in an acidic tumor microenvironment due to the protonation of diethylaminophenyl units. Most important, the antivascular agent 5,6-dimethylxanthenone-4-acetic acid, targeting the vascular endothelial growth factor, can be smartly released from the pro-drug DAA via ester bond hydrolysis at the subacid endocytosis organelles in the endothelial cells, which can effectively destroy the vascular region to prevent tumor proliferation and metastasis. Hence, DAA NPs can specifically target vascular endothelial cells and tumorous lysosomes with desired cellular damage properties in vitro. Therefore, the tumors can be ablated completely with no recurrence and side effects in vivo, which implies that DAA NPs provide a promising approach for cancer treatment via synergistic antivascular activity and photodynamic/photothermal therapy.

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Section: Resultsmentioning

confidence: 99%

Tumor-Microenvironment-Responsive Nanoconjugate for Synergistic Antivascular Activity and Phototherapy

Liang¹,

Huang²,

Wang³

et al. 2018

ACS Nano

131

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“…Epithelioid angiosarcoma generally shows positivity to CD31 and 34, Fli 1, ERG and claudin-5, with the expression of immunohistochemical stains CD31 and CD34 being variable [ 9 , 10 , 23 ]. ERG, on the other hand, has the highest sensitivity (reaching 100%) and a high specificity [ [23] , [24] , [25] ].…”

Section: Discussionmentioning

confidence: 99%

Intraoral angiosarcoma with unusual clinical presentation: A case report

Al‐Ali

Al-Otaibi

AlMohaya

et al. 2023

Heliyon

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“…Clinical and pathological findings are necessary for diagnosis, and hematoxylin and eosin staining and immunohistochemistry are essential. Immunohistochemical staining includes the lymphatic endothelial marker D2-40 (podoplanin) and the vascular endothelial markers Factor-VIII-related antigen (Factor-VIIIRA), CD31, CD34 [18], vascular endothelial growth factor (VEGF), and ERG [19, 20].…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Angiosarcoma with Persistent Unilateral Eyelid Swelling

Sakisaka

Tanabe

Imayama³

et al. 2021

Ocul Oncol Pathol

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Angiosarcoma is a widely known neoplasm with one of the poorest prognoses; however, such cases are rarely observed by the ophthalmologists in clinical practice. The tumor commonly develops on the face and scalp and may cause eyelid swelling. We present two such cases. Case 1 was an 82-year-old woman who presented with indulated swelling of the right eyelid that extended to the upper forehead. Biopsy revealed a poorly circumscribed tumor infiltrated throughout the dermis and fat tissue, exhibiting both angiomatous and solid patterns. Immunohistochemistry showed CD31 (-) and D2-40/podoplanin(+), suggesting angiosarcoma. The patient had multiple lung metastases and died 14 months later. Case 2 was a 77-year-old man who presented with swelling of the left eyelid and erythema on the left temporal skin developed ulcerated nodules. Biopsy showed proliferated tumor cells in a sheet form, extensively throughout the dermis. Angiosarcoma was preferred based on immunohistochemistry: CD31(+), CD34(+), D2-40(-). The patient was treated with electron beam therapy and chemotherapy, and died after 13 months. It would be difficult for an ophthalmologist to suspect such a rare neoplasm only from swelling of the eyelids. However, angiosarcoma should be considered if the swelling spreads steadily from a head rash with a nodule or ulcer nearby.

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Effectiveness Of Vascular Markers (immunohistochemical Stains) In Soft Tissue Sarcomas

Cited by 9 publications

References 0 publications

Tumor-Microenvironment-Responsive Nanoconjugate for Synergistic Antivascular Activity and Phototherapy

Tumor-Microenvironment-Responsive Nanoconjugate for Synergistic Antivascular Activity and Phototherapy

Intraoral angiosarcoma with unusual clinical presentation: A case report

Two Cases of Angiosarcoma with Persistent Unilateral Eyelid Swelling

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