Effectiveness of various toothpastes on dentine tubule occlusion

Arnold, Wolfgang H.; Prange, M.; Naumova, Ella A.

doi:10.1016/j.jdent.2015.01.014

Cited by 87 publications

(86 citation statements)

References 40 publications

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“…For the treatment of dentin hypersensitivity, several different strategy of treatment have being studied. One of these strategies is to occlude the exposed dentin surface, especially the tubule orifices, by using various agents that includes different active ingredients (Arnold et al, ; Earl et al, ; Tian et al, ). Since hydroxyapatite is one of the main components of human bones and teeth and it has good biocompatibility and bioactivity, synthetic hydroxyapatite has become one of the hot topics for biological material research over the past few decades (Cummins, ; Lee et al, ; Lin et al, ; Wang et al, ; Yu et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…It is imperative that in vitro experiments be performed before a newly developed material is used in humans. Hence, in this present in vitro study it was aimed to investigate the dentin tubule occluding capability of experimental pure and 1%, 2%, and 3% F − doped nHAp types by using a reproducible and feasible dentin disc model (Arnold et al, ; Kim et al, ; Pashley et al, ; Wang et al, ; Yuan et al, ). For this purpose, SEM and ATR‐FTIR analysis methods were used to determine the occluding capability of these materials.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the increase of population age also increased the teeth's (Cummins, ). These factors can lead to an increase in frequency of noncaries lesions as erosion, attrition, abrasion, abfraction or gingival recession which may cause the exposure of dentinal tubules to the oral cavity (Arnold, Prange, & Naumova, ; Earl, Leary, Muller, Langford, & Greenspan, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Dentinal tubule occluding capability of nano‐hydroxyapatite; The in‐vitro evaluation

Bağlar

Erdem

Doğan

et al. 2018

Microscopy Res & Technique

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In this in-vitro study, the effectiveness of experimental pure nano-hydroxyapatite (nHAP) and 1%, 2%, and 3% F¯ doped nano-HAp on dentine tubule occlusion was investigated. And also, the cytotoxicity of materials used in the experiment was evaluated. Nano-HAp types were synthesized by the precipitation method. Forty dentin specimens were randomly divided into five groups of; 1-no treatment (control), 2-specimens treated with 10% pure nano-HAp and 3, 4, 5 specimens treated with 1%, 2%, and 3% F doped 10% nano-HAp, respectively. To evaluate the effectiveness of the materials used; pH, FTIR, and scanning electron microscopy evaluations were performed before and after degredation in simulated body fluid. To determine cytotoxicity of the materials, MTT assay was performed. Statistical evaluations were performed with F and t tests. All of the nano-HAp materials used in this study built up an effective covering layer on the dentin surfaces even with plugs in tubules. It was found that this layer had also a resistance to degradation. None of the evaluated nano-HAp types were have toxicity. Fluoride doping showed a positive effect on physical and chemical stability until a critical value of 1% F . The all evaluated nano-HAp types may be effectively used in dentin hypersensitivity treatment. The formed nano-HAp layers were seem to resistant to hydrolic deletion. The pure and 1% F doped nano-HAp showed the highest biocompatibility thus it was assessed that pure and 1% F doped materials may be used as an active ingredient in dentin hypersensitivity agents.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dentinal tubule occluding capability of nano‐hydroxyapatite; The in‐vitro evaluation

Bağlar

Erdem

Doğan

et al. 2018

Microscopy Res & Technique

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“…In this way, desensitizing toothpastes that act occluding tubules can reduce dentine sensitivity (3). These toothpastes can occlude superficially the dentine tubules, process that is dependent on the active ingredients of each toothpaste, such as Pro-Argin, Calcium carbonate, Strontium acetate, Stannous fluoride, Zinc-carbonate hydroxyapatite, New silica, Tetrapotassium pyrophosphate and Hydroxyapatite (4). On the other hand, Potassium based toothpastes have been used to block neural transmission.…”

Section: Introductionmentioning

confidence: 99%

Are Desensitizing Toothpastes Equally Biocompatible and Effective Against Microorganisms?

et al. 2017

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The aims of this study were evaluate cytotoxicity, genotoxicity, antimicrobial activity of desensitizing toothpastes compared to a common one and the surface roughness of tooth enamel submitted to brushing with these toothpastes. Samples of three desensitizing toothpastes (Colgate Sensitive, Sensodyne and Oral B Sensitive) and common toothpaste (Colgate) were placed in contact with gingival human fibroblasts. Cytotoxicity and genotoxocity were measured by MTT assay and micronucleus test. Antimicrobial activity of the toothpastes extracts against C. albicans, S. mutans and S. aureus were assessed. For surface roughness evaluation, bovine teeth were submitted to 10.000 brushing cycles. The results were analyzed statically using Mann-Whitney U, ANOVA and Z tests (p<0.05). All toothpastes caused cytotoxic effect to the cells (p<0.05), except Colgate Sensitive. The toothpastes did not increase the number of micronuclei compared to the untreated control group. Colgate eliminated all the evaluated microorganisms at lower concentrations compared to Colgate Sensitive and Oral B Sensitive, which were not able to eliminate S. aureus. Sensodyne did not reach the minimum microbicidal concentration. The surface roughness of tooth enamel increased after brushing with Colgate Sensitive and Oral B Sensitive, however the comparison between groups showed no difference on the enamel surface roughness presented by desensitizing toothpastes when compared with the common one (p>0.05). Based on these results, we can conclude that although none toothpaste has induced genotoxicity, Colgate Sensitive was also not cytotoxic. Colgate was the most effective against the microorganisms, and there were no differences on the enamel surface roughness between the groups.

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“…Prerequisite for remineralization is a suffi cient supply of Ca 2+ and PO 4 3− ions. Fluoride should promote dentin remineralization, whereas other ingredients like pro-arginin or hydroxyapatite are aimed to occlude open dentin tubules for diminishing dentin hypersensitivity (Arnold et al 2015 ). Fluoride promotes remineralizaion of hydroxyapatite and is widely used in the prevention and restoration of dentin erosions.…”

Section: Restoration Of Cervical Dentin Erosionsmentioning

confidence: 99%

Understanding Dental Caries

Goldberg¹

2016

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Effectiveness of various toothpastes on dentine tubule occlusion

Abstract: Desensitizing toothpastes are the most common products that are used against dentine hypersensitivity, and these toothpastes affect dentine tubule occlusion.

Cited by 87 publications

References 40 publications

Dentinal tubule occluding capability of nano‐hydroxyapatite; The in‐vitro evaluation

Dentinal tubule occluding capability of nano‐hydroxyapatite; The in‐vitro evaluation

Are Desensitizing Toothpastes Equally Biocompatible and Effective Against Microorganisms?

Understanding Dental Caries

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